Results 91 to 100 of about 226,757 (260)

Contraindicated drug–drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background and Purpose Drug–drug interactions (DDIs) are associated with an increased risk of adverse drug reactions (ADRs). Hospitalized children are particularly vulnerable to DDIs and ADRs due to polypharmacy, frequent use of unlicensed or off‐label medications, and dosing regimens often extrapolated from adult data.
Emilie Laval, Sylvain Goutelle, Inesse Boussaha, Xavier Dode, Yanis Mimouni, Kim An Nguyen, Behrouz Kassai   +6 more
wiley   +1 more source

Exploring new avenues: Psychedelic‐assisted therapy for young people

British Journal of Clinical Pharmacology, EarlyView.
Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic‐assisted therapy, using substances such as psilocybin and 3,4‐methylenedioxymethamphetamine (MDMA), has shown potential in the treatment of mental illnesses in the adult population, including ...
Ioanna Artemis Vamvakopoulou, Dasha Nicholls, David J. Nutt, Martina Di Simplicio   +3 more
wiley   +1 more source

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

Suicide

New England Journal of Medicine, 2020
Mark, Sinyor, Thomas, Niederkrotenthaler, Jane, Pirkis   +2 more
  +10 more sources

Cerebellar astrocytic alterations in depression

Translational Psychiatry
Accumulating evidence suggests dysfunction of cerebellar-cerebral circuits in depression. However, the potential cellular and molecular alterations associated with depression in the cerebellum remain largely uncharacterized.
Christa Hercher, Gina Abajian, Maria Antonietta Davoli, Gustavo Turecki, Naguib Mechawar   +4 more
doaj   +1 more source

Listening to Hong Kong children's perspectives through pretend play

British Educational Research Journal, EarlyView.
Abstract Quality in early childhood education and care (ECEC) has become an increasing concern in recent years. The issue has been regularly discussed by different stakeholders. However, the rising concern regarding quality in ECEC has not seriously taken into account children's perspectives.
Suzannie K. Y. Leung
wiley   +1 more source

Understanding the needs and perspectives of young adults with recent suicidal ideation: insights for suicide prevention

Frontiers in Child and Adolescent Psychiatry
IntroductionSuicide rates among adolescents and young people are increasing, especially in Western countries. Suicidal ideation often precedes suicide attempts and suicide.
Milou Looijmans, Milou Looijmans, Elke Elzinga, Elke Elzinga, Arne Popma, Diana van Bergen, Diana van Bergen, Renske Gilissen, Saskia Mérelle   +8 more
doaj   +1 more source

‘When joy comes your way, you have to grab it!’ Troubling how queer joy features in the lives of LGBT+ school‐attending youth in South Africa

British Educational Research Journal, EarlyView.
Abstract Recently, the concept ‘queer joy’ has gained interest in LGBT+ scholarship in the West. I use this scholarship as an entry point to explore how school‐attending LGBT+ youth express joy and how joy serves as a form of resistance against gender and sexuality norms in educational settings.
Dennis Francis
wiley   +1 more source

‘School is their whole world’: Teachers' perspectives on loneliness among children and adolescents from England and mainland China

British Educational Research Journal, EarlyView.
Abstract As front‐line observers and active participants in pupils' daily lives, teachers closely monitor pupils' social interactions, emotional states and behavioural changes. Their unique perspective enables them to detect problems in the social lives of their pupils that may not be immediately visible to peers, parents or mental health professionals.
Yixuan Zheng, Charlotte Bagnall, Caroline Bond, Elizabeth Birchinall, Pamela Qualter   +4 more
wiley   +1 more source

“You wished the ground would open and swallow you up”: Expert opinions on shame, the collective, and other cultural considerations for suicide prevention among Asian American and Pacific Islander veterans

Injury Epidemiology
Background Rates of suicide remain elevated among U.S. Veterans and have increased disproportionately among Asian American and Pacific Islander (AAPI) Veterans.
Evan R. Polzer, Carly M. Rohs, Christe’An D. Iglesias, Joseph Mignogna, Lauren S. Krishnamurti, Ryan Holliday, Lindsey L. Monteith   +6 more
doaj   +1 more source