Results 31 to 40 of about 20,508 (261)
Impact of foliar nitrogen supplementation on Chardonnay and Sauvignon Blanc wines
IVES Technical ReviewsThe effectiveness of an application of foliar nitrogen at veraison depends on the initial level of vine nitrogen deficiency, an Agroscope study has shown.
Thibaut Verdenal +4 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Gestion raisonnée de l’azote en viticulture : de l’observation à l’analyse du moût
IVES Technical ReviewsComprendre et gérer la nutrition azotée de la vigne est crucial pour produire des vins de qualité. L'observation visuelle est la première étape, complétée par des outils comme l'indice chlorophyllien et l’analyse foliaire.
Thibaut Verdenal +4 more
doaj +1 more source
Science of Nursing and Health Practices, 2022 Introduction : L’émergence de la COVID-19 a mis à l’épreuve les systèmes de soins. À Genève (Suisse), les services de soins infirmiers à domicile sont très mobilisés auprès des personnes les plus vulnérables pour faire face aux problématiques de ...
Olivier Perrier-Gros-Claude +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Parasites & Vectors, 2018 Background Preventive chemotherapy with donated anthelminthic drugs is the cornerstone for the control of helminthiases. However, reinfection can occur rapidly in the absence of clean water and sanitation coupled with unhygienic behaviour. The purpose of
Eveline Hürlimann +14 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Pour une réappropriation de l’évaluation par la participation
Revue Internationale Animation, Territoires et Pratiques Socioculturelles, 2015 Avec la récession budgétaire qui marque l’ensemble des pays occidentaux, l’évaluation a connu un engouement sans précédent et a fait son entrée dans tous les champs professionnels, y compris celui du social.
Ulrike Armbruster Elatifi +2 more
doaj +1 more source