Results 51 to 60 of about 30,767 (267)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
RELATO DE CASO: LINFOMA/LEUCEMIA LINFOBLÁSTICO DE CÉLULAS T REFRATÁRIO
Hematology, Transfusion and Cell Therapy, 2023 Introdução: O linfoma linfoblástico de células T (LLB T) é um tipo de Linfoma não Hodgkin, podendo ser classificado como linfoma ou leucemia linfoblástica aguda dependendo do nível de acometimento da medula óssea (MO).
AH Schuck +8 more
doaj +1 more source
Cadernos do LEPAARQ (UFPEL), 2016 Título original: Caximbos in Süd-Brasilien. Publicado na Zeitschrift für Ethnologie. Organ der Berliner Gesellschaft für Anthropologie, Ethnologie und Urgeschichte. Vol. 23, 1891, p. 695-698. A tradução procurou manter a pontuação, as maiúsculas e minúsculas fora de lugar e os maneirismos da redação de August Kunert.
openaire +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Brazilian Journal of Infectious Diseases, 2022 Introdução/Objetivo: O SARS-COV-2 mostrou-se uma grave ameaça à saúde global. O grande número de infectados desencadeou altas taxas de mortalidade e sobrecarga do sistema de saúde. O prognóstico da doença é muito variável e dependente de diversos fatores.
Viviane Raquel Buffon +8 more
doaj +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
Brazilian Journal of Infectious Diseases, 2022 Introdução/Objetivo: A Covid-19 pode apresentar-se de forma assintomática até quadros críticos de insuficiência respiratória aguda com complicações sistêmicas.
Viviane Raquel Buffon +8 more
doaj +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
RELATO DE CASO: LINFOMA MALT DE CECO
Hematology, Transfusion and Cell Therapy, 2023 Introdução: O linfoma do tecido linfoide associado à mucosa (MALT), pertence ao grupo dos linfomas não-Hodgkin e é considerado uma doença indolente e rara.
TS Hahn +8 more
doaj +1 more source
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source