Results 51 to 60 of about 31,792 (268)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

RELATO DE CASO: LINFOMA/LEUCEMIA LINFOBLÁSTICO DE CÉLULAS T REFRATÁRIO

open access: yesHematology, Transfusion and Cell Therapy, 2023
Introdução: O linfoma linfoblástico de células T (LLB T) é um tipo de Linfoma não Hodgkin, podendo ser classificado como linfoma ou leucemia linfoblástica aguda dependendo do nível de acometimento da medula óssea (MO).
AH Schuck   +8 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

open access: yesFEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo   +4 more
wiley   +1 more source

MORTALIDADE EM PACIENTES ADMITIDOS POR COVID-19 NA UNIDADE DE TERAPIA INTENSIVA DO HOSPITAL GERAL DE CAXIAS DO SUL

open access: yesBrazilian Journal of Infectious Diseases, 2022
Introdução/Objetivo: O SARS-COV-2 mostrou-se uma grave ameaça à saúde global. O grande número de infectados desencadeou altas taxas de mortalidade e sobrecarga do sistema de saúde. O prognóstico da doença é muito variável e dependente de diversos fatores.
Viviane Raquel Buffon   +8 more
doaj   +1 more source

Répteis do Mato Grosso do Sul, Brasil [PDF]

open access: yesIheringia. Série Zoologia, 2017
RESUMO Informações sobre riqueza e composição de répteis pela primeira vez são apresentadas para o Mato Grosso do Sul (MS). A compilação de dados foi baseada em publicações, coleções científicas e dados disponibilizados por pesquisadores. Foram registradas 188 espécies distribuídas em oito espécies de Testudines, três Crocodylia e 177 Squamata (16 ...
Ferreira, Vanda Lúcia   +15 more
openaire   +5 more sources

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

open access: yesFEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima   +7 more
wiley   +1 more source

SOBREVIDA DOS PACIENTES COM COVID-19 ADMITIDOS NAS UNIDADES DE TERAPIA INTENSIVA DO HOSPITAL GERAL DE CAXIAS DO SUL

open access: yesBrazilian Journal of Infectious Diseases, 2022
Introdução/Objetivo: A Covid-19 pode apresentar-se de forma assintomática até quadros críticos de insuficiência respiratória aguda com complicações sistêmicas.
Viviane Raquel Buffon   +8 more
doaj   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza   +19 more
wiley   +1 more source

RELATO DE CASO: LINFOMA MALT DE CECO

open access: yesHematology, Transfusion and Cell Therapy, 2023
Introdução: O linfoma do tecido linfoide associado à mucosa (MALT), pertence ao grupo dos linfomas não-Hodgkin e é considerado uma doença indolente e rara.
TS Hahn   +8 more
doaj   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio   +8 more
wiley   +1 more source

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