Results 71 to 80 of about 559,898 (313)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Cadeias de Produtos da Sociobiodiversidade no Sul do Brasil: Valorização de Frutas Nativas da Mata Atlântica no Contexto do Trabalho com Agroecologia

, 2018
O presente artigo discute o conceito de cadeias de produtos da sociobiodiversidade, identificando elementos definidores e ameacas presentes na consolidacao desses arranjos socioprodutivos.
Mariana Oliveira Ramos, Fabiana Thomé da Cruz, Gabriela Coelho de Souza, R. Kubo   +3 more
semanticscholar   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Multidrug-resistant Staphylococcus chromogenes pyoderma in Rattus norvegicus: case report

Medicina Veterinária
This case study investigated a multidrug-resistant Staphylococcus pyoderma infection in a pet Rattus norvegicus. The clinical presentation involved a range of clinical signs, including pruritus, inflammation, pustules, and crusts on the skin, indicative
Julia Facchin Tronca, Felipe Esteves da Silva, Alessandra Gugel Piccinini, Vitória Damin , Gustavo Brambatti, Fabiane Prusch, André Felipe Streck   +6 more
doaj   +3 more sources

LEUCEMIA MIELOIDE AGUDA INDIFERENCIADA REFRATÁRIA EM PACIENTE PEDIÁTRICO

Hematology, Transfusion and Cell Therapy, 2023
Introdução: As leucemias são as neoplasias mais frequentes na infância, sendo a leucemia mieloide aguda (LMA) apenas 15% dos casos. Estas são comumente classificadas de acordo com sua morfologia (FAB), tendo o subtipo indiferenciado chamado de M0, que ...
EW Silva, GCL Bellini, TS Hahn, MFL Pezzi, AH Schuck, BK Losch, LV Calderan, LM Lorenzini, A Kittel, ACF Segatto, KCN Corbellini   +10 more
doaj   +1 more source

Tomada de decisão e a sucessão na agricultura familiar no sul do Brasil

, 2017
A ausencia de sucessores na agricultura familiar tende a gerar incertezas nao apenas no que confere a continuidade das familias e das atividades produtivas, mas tambem sobre as comunidades rurais, as quais gradativamente perdem sua populacao e passam a ...
Alessandra Matte, J. A. D. Machado
semanticscholar   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

RELATO DE CASO: LINFOMA MALT DE CECO

Hematology, Transfusion and Cell Therapy, 2023
Introdução: O linfoma do tecido linfoide associado à mucosa (MALT), pertence ao grupo dos linfomas não-Hodgkin e é considerado uma doença indolente e rara.
TS Hahn, VT Almeida, AH Schuck, LV Calderan, EW Silva, LM Lorenzini, BK Losch, MFL Pezzi, RD Lorandi   +8 more
doaj   +1 more source

Condições de saúde bucal da população indígena guarani moradora no Sul do Brasil

, 2019
Resumo Introdução A saúde bucal das populações indígenas brasileiras foi historicamente negligenciada. Recentemente tem sido dada atenção especial por meio da Política Nacional de Saúde Bucal Indígena.
Julio Baldisserotto, A. M. Ferreira, Cristine Maria Warmling   +2 more
semanticscholar   +1 more source

Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce, Goknur Selen Kocak, José Verdú‐Díaz, Jorge Alonso‐Pérez, Kristl G. Claeys, Tanya Stojkovic, Gorka Fernández‐Eulate, Pascal Laforêt, Najoua Miladi, Filipe Di Pace, Cristiane Araujo Martins Moreno, Edmar Zanoteli, Conrad C. Weihl, Volker Straub, Ana Töpf, Jordi Díaz‐Manera, Sarcoglycan European Cohort Consortium, Adele D′Amico, Adolfo López de Munain, Alicia Alonso‐Jiménez, Ana Camacho‐Salas, Andrea Gangfuß, Andrés Nascimento, Anna Sarkozy, Anneke J. van der Kooi, Arturo Fraga‐Bau, Béla Melegh, Benedikt Schoser, Bjarne Udd, Blaz Koritnik, Carlos Ortez, Chiara Marini Bettolo, Chiara Panicucci, Claudia Weiss, Claudio Bruno, Claudio Semplicini, Cristina Dominguez‐González, Cristina Garrido, David Gómez‐Andrés, Edoardo Malfatti, Elena Pegoraro, Elke De Vos, Francina Munell, Gabriele Dekomien, Giacomo Pietro Comi, Giorgio Tasca, Isabelle Richard, Jan L. De Bleecker, Jana Haberlová, Jesper Helbo Storgaard, Johanna Palmio, John Vissing, Juan Carlos de Leon‐Hernández, Kinga Hadzsiev, Laura Costa‐Comellas, Lea Leonardis, Leroy ten Dam, Lidia González‐Quereda, Luca Bello, Luisa Politano, Manuela Santos, Marianne de Visser, Marie Rohlenová, Matteo Garibaldi, Michela Guglieri, Nicolas Deconinck, Nicoline Løkken, Omar Abdel‐Mannan, Pia Gallano, Roberto Fernández‐Torrón, Ulrike Schara‐Schmidt, Vincenzo Nigro, Vittoria Zangaro   +72 more
wiley   +1 more source