Results 91 to 100 of about 24,648 (256)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Decolonizar o pensamento decolonial
(Des)troçosO pensamento decolonial vem, na última década, tornando-se pujante no campo das ciências humanas no Brasil, sobretudo por meio da introdução de teorias produzidas pelo Grupo Modernidade/Colonialidade e por Boaventura de Sousa Santos.
Bruno dos Santos Joaquim
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Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Sul Global: Milton Santos, o geógrafo que moldou os territórios do Sul Global
This article commemorates the centenary of Brazilian geographer Milton Santos (1926-2001), one of the leading figures in world geography and the concept of solidarity-based globalisation. It explores his critique of hegemonic globalisation, his analysis of the two circuits of the urban economy, and his relevance for understanding the Global South.
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Artes feministas : artivismos e sul global
, 2022 Oliveira, Cláudia de, Guerra, Paula
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Vozes do Sul: Pesquisas sobre as Epistemologias Alternativas no Sul Global
Palimpsesto - Revista do Programa de Pós-Graduação em Letras da UERJEste artigo propõe uma reflexão sobre as “vozes do Sul” (Pennycook, 2006) como formas de resistência epistemológica frente às dinâmicas de colonialidade que ainda atravessam a produção global de saberes. Inspirado pelas contribuições de Pennycook (2006), Sousa Santos (2010), Mignolo (2009), bell hooks (1994) e Anzaldúa (1987), o trabalho analisa como ...
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source