Results 101 to 110 of about 827 (180)

Carbapenem Resistance in Acinetobacter baumannii: Mechanisms, Therapeutics, and Innovations

Microorganisms
The global rise of carbapenem-resistant Acinetobacter baumannii (CRAB) strains poses a critical challenge to healthcare systems due to limited therapeutic options and high mortality rates, especially in intensive care settings.
Joyce de Souza, Helena Regina Salomé D’Espindula, Isabel de Farias Ribeiro, Geiziane Aparecida Gonçalves, Marcelo Pillonetto, Helisson Faoro   +5 more
doaj   +1 more source

β-Lactam/β-Lactamase Inhibitor Combinations in Sepsis-Associated Acute Kidney Injury and Renal Replacement Therapy

Antibiotics
Sepsis-associated acute kidney injury (SA-AKI) often requires renal replacement therapy (RRT), which markedly alters antimicrobial pharmacokinetics (PK) and pharmacodynamics (PD). Novel β-lactam/β-lactamase inhibitor (BL/BLI) combinations broaden options
Antonio Lacquaniti, Valentina Pistolesi, Antonella Smeriglio, Domenico Santoro, Cristina Iannetti, Giuseppe Lentini, Roberto Chimenz, Valeria Chirico, Domenico Trombetta, Santo Morabito, Paolo Monardo   +10 more
doaj   +1 more source

Antibiotic Treatment of Carbapenem-Resistant Acinetobacter baumannii Infections in View of the Newly Developed β-Lactams: A Narrative Review of the Existing Evidence

Antibiotics
It is estimated that antimicrobial resistance (AMR) is responsible for nearly 5 million human deaths worldwide each year and will reach 10 million by 2050.
Francesca Serapide, Maurizio Guastalegname, Sara Palma Gullì, Rosaria Lionello, Andrea Bruni, Eugenio Garofalo, Federico Longhini, Enrico Maria Trecarichi, Alessandro Russo   +8 more
doaj   +1 more source

Friends or foes? Novel antimicrobials tackling MDR/XDR Gram-negative bacteria: a systematic review

Frontiers in Microbiology
Gram-negative bacteria have been one of the most studied classes in the field of microbiology, especially in the context of globally alarming antimicrobial resistance levels to these pathogens over the course of the past decades.
Mihai Octavian Dan, Daniela Tǎlǎpan, Daniela Tǎlǎpan   +2 more
doaj   +1 more source

Nephrotoxicity of New Antibiotics: A Systematic Review

Toxics
Drug-induced nephrotoxicity is a common and serious problem in clinical practice. We conducted a systematic review of studies reporting nephrotoxicity events associated with antibiotics approved since 2018.
Panagiotis Stathopoulos, Laura T. Romanos, Charalampos Loutradis, Matthew E. Falagas   +3 more
doaj   +1 more source

Opciones terapéuticas para infecciones por gérmenes ESKAPE en países de bajos recursos. Revisión sistemática [PDF]

Introducción: El término ESKAPE, acuñado hace más de una década, designa a un grupo de bacterias que tienen la habilidad de “escapar” a la acción de los antibióticos.
Castro Reyes, Evelyn Elizabeth, Ortiz Porteros, Leopoldo Vinicio   +1 more
core   +1 more source

Current Advances in Developing New Antimicrobial Agents Against Non-Tuberculous Mycobacterium

Antibiotics
Non-tuberculous mycobacteria (NTM) comprise more than 190 species capable of causing severe pulmonary, lymphatic, cutaneous, and disseminated infections, particularly in immunocompromised populations.
Jane Cross, Nupur Gargate, Khondaker Miraz Rahman   +2 more
doaj   +1 more source

Novel Insights into Carbapenem Resistance: Mechanisms, Diagnostics, and Future Directions

Antibiotics
Carbapenems are essential for the treatment of severe infections caused by Gram-negative bacteria, particularly in critically ill and immunocompromised patients.
Ionela-Larisa Miftode, Viorel Dragoș Radu, Raul-Alexandru Jigoranu, Daniela-Anicuța Leca, Cristian Sorin Prepeliuc, Maria Antoanela Pasare, Radu-Stefan Miftode, Maria Gabriela Grigoriu, Tudorița Gabriela Parângă, Egidia Gabriela Miftode   +9 more
doaj   +1 more source

Epidemiology, resistance genomics and susceptibility of Acinetobacter species: results from the 2020 Spanish nationwide surveillance study [PDF]

[Abstract]: Background: As increasing antibiotic resistance in Acinetobacter baumannii poses a global healthcare challenge, understanding its evolution is crucial for effective control strategies.
Alonso-Garcia, Isaac, Arca-Suárez, Jorge, Beceiro, Alejandro, Bou, Germán, Fernández-Lozano, Carlos, González-Pinto, Lucía, Guijarro, Paula, Lasarte-Monterrubio, Cristina, Maceiras, Romina, Martínez-Guitián, Marta, Outeda, Michelle, Vázquez-Ucha, Juan Carlos   +11 more
core   +2 more sources

Global trends in carbapenem-resistant gram-negative bacteria research (2020–2025): a bibliometric analysis and systematic review

Frontiers in Cellular and Infection Microbiology
BackgroundCarbapenem-resistant Gram-negative bacteria (CRGNB) pose a severe global health threat, yet comprehensive bibliometric analyses in this field remain limited.
Xiaotong Zhang, Xiaotong Zhang, Xiaotong Zhang, Ce Zhang, Ce Zhang, Ce Zhang, Mengyao Lv, Mengyao Lv, Mengyao Lv, Shu Wang, Shu Wang, Shu Wang, Qiuting Wang, Qiuting Wang, Qiuting Wang, Chengshuai Yang, Chengshuai Yang, Chengshuai Yang, Qian Zhao, Luyuan Ma, Luyuan Ma, Luyuan Ma, Bei Li, Xiaohua Qin, Caiyan Zhao, Caiyan Zhao, Caiyan Zhao, Chuan Shen, Chuan Shen, Chuan Shen   +29 more
doaj   +1 more source