Results 1 to 10 of about 7,278 (228)
Modified Synthesis of Four Kinds of Azabicyclo Compounds [PDF]
Chinese Journal of Applied Chemistry, 2012 Azabicyclo compounds of 1,4-benxodiazine,pyridopyrazine,1H-benzimidazole,3H-imidazopyridine were prepared from o-phenylenediamine or 2,3-diaminopyridine reacted with carbonyl compounds.The effects of reaction medium,pH,time and other factors on the reactions were invesitigated.The results showed that the yield of pyridopyrazine could reach 89.4% when ...
Yu Wang, Ming Lu
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Pyrrolidine synthesis via ring contraction of pyridines [PDF]
Nature CommunicationsA ring contraction of easily available cyclic compounds to smaller cycles that are valuable but difficult to synthetically access is one of important skeletal editing strategies.
Ryoga Ueno, Shohei Hirano, Jun Takaya
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Chemical and Pharmaceutical Bulletin, 1973 A new synthesis of the spirodiamines (IIIa-c) from the methiodides (Ia-c) via the spiroaminolactams (VIIa-c) by Stevens rearrangement is described.
Hideo Kato +3 more
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HFIP-assisted Brønsted acid-catalyzed ring opening of 1-azabicyclo[1.1.0]butane to access diverse C3-quaternary aza-azetidines and indole-azetidines [PDF]
Nature CommunicationsNitrogen-based heterocycles represent 60% of small-molecule-approved drugs. Increasing demand for sp3-rich N-heterocyclic scaffolds as a bioisosteric replacement in drug discovery platforms has continued to drive the development of elegant methods for ...
Subrata Hazra +6 more
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3-(3-Azabicyclo[2, 2, 1]heptan-2-yl)-1,2,4-oxadiazoles as Novel Potent DPP-4 Inhibitors to Treat T2DM [PDF]
PharmaceuticalsBackground: Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disease with global implications, necessitating effective management strategies.
Tatiana V. Zinevich +7 more
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PdII‐Mediated Oxidative Amination for Access to a 9‐Azabicyclo[4.2.1]nonane Compound Library and Anatoxin‐a [PDF]
European Journal of Organic Chemistry, 2018 Intramolecular oxidative amination of readily accessible aminocyclooct‐4‐enes provides rapid and regioselective access to the 9‐azabicyclo[4.2.1]nonane framework characteristic of the natural product anatoxin‐a (1). This has enabled the synthesis of sp3‐rich chemical scaffolds suitable for diversification.
Rafid S. Dawood +11 more
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Study of Cytotoxicity of Spiro-Fused [3-Azabicyclo[3.1.0]hexane]oxindoles and Cyclopropa[a]pyrrolizidine-oxindoles Against Tumor Cell Lines [PDF]
PharmaceuticalsBackground: A series of spiro-fused heterocyclic compounds containing cyclopropa[a]pyrrolizidine-2,3′-oxindole and 3-spiro[3-azabicyclo[3.1.0]-hexane]oxindole frameworks were synthesized and studied for their in vitro antiproliferative activity against ...
Anton A. Kornev +4 more
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Chemical and Pharmaceutical Bulletin, 1972 Monoester of benzylmalonic acid (I) and 3-carboxy-4-octahydroquinolizinone (V) were coupled with benzenediazonium salt to yield labile phenylhydrazones, Iia and VII, respectively. IIa was kept standing in chloroform or heated to give another phenylhydrazone (IIb). VIa was similarly converted into VIb.
Yoshio Arata, M. SAKAI, Shingo Yasuda
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The Synthesis And Properties Of 9-azabicyclo (3.3.1)nonane Compounds.
, 1974 PhD ; Organic chemistry ; University of Michigan, Horace H. Rackham School of Graduate Studies ; http://deepblue.lib.umich.edu/bitstream/2027.42/191102/2/7510206 ...
Herman Otto Krabbenhoft
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Chemical and Pharmaceutical Bulletin, 1991 Reductive amido bond cleavage reaction, previously elaborated by our laboratory for the synthesis of carbocyclic ribothymidine from readily available 2-azabicyclo[2.2.1]hept-5-en-3-one, was successfully applied to the synthesis of carbocyclic analogues of thymidine and related compounds.
Nobuya Katagiri +3 more
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