Results 1 to 10 of about 3,717 (151)

Pyrrolidine synthesis via ring contraction of pyridines. [PDF]

Nat Commun
A ring contraction of easily available cyclic compounds to smaller cycles that are valuable but difficult to synthetically access is one of important skeletal editing strategies.
Ueno R, Hirano S, Takaya J.
europepmc   +2 more sources

3-(3-Azabicyclo[2, 2, 1]heptan-2-yl)-1,2,4-oxadiazoles as Novel Potent DPP-4 Inhibitors to Treat T2DM. [PDF]

Pharmaceuticals (Basel)
Background: Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disease with global implications, necessitating effective management strategies.
Zinevich TV, Maslov IO, Kirichenko OG, Shorshnev SV, Gureev MA, Dolgushin FM, Porozov YB, Trukhan VM.   +7 more
europepmc   +2 more sources

HFIP-assisted Brønsted acid-catalyzed ring opening of 1-azabicyclo[1.1.0]butane to access diverse C3-quaternary aza-azetidines and indole-azetidines. [PDF]

Nat Commun
Nitrogen-based heterocycles represent 60% of small-molecule-approved drugs. Increasing demand for sp3-rich N-heterocyclic scaffolds as a bioisosteric replacement in drug discovery platforms has continued to drive the development of elegant methods for ...
Hazra S, Tyagi A, Dutta T, Sahoo R, Bandyopadhyay B, Jindal G, Panda S.   +6 more
europepmc   +2 more sources

Effects of 5 aminolevulinic acid on fruit quality and volatile metabolites of Meizao sweet cherry. [PDF]

Sci Rep
5-Aminolevulinic acid (5-ALA) is an endogenous amino acid and a precursor of chlorophyll synthesis. Studies have shown that it can promote fruit development and improve quality characteristics such as sweetness, acidity, and flavor.
Guo H, Zhang J, Wang H, Yang X, Su X, Liu J, Li P.   +6 more
europepmc   +2 more sources

Study of Cytotoxicity of Spiro-Fused [3-Azabicyclo[3.1.0]hexane]oxindoles and Cyclopropa[a]pyrrolizidine-oxindoles Against Tumor Cell Lines. [PDF]

Pharmaceuticals (Basel)
Background: A series of spiro-fused heterocyclic compounds containing cyclopropa[a]pyrrolizidine-2,3′-oxindole and 3-spiro[3-azabicyclo[3.1.0]-hexane]oxindole frameworks were synthesized and studied for their in vitro antiproliferative activity against ...
Kornev AA, Shmakov SV, Ponyaev AI, Stepakov AV, Boitsov VM.   +4 more
europepmc   +2 more sources

Synthesis and Antiprotozoal Activity of Azabicyclo-Nonane Pyrimidine Hybrids

Molecules, 2022
2,4-Diaminopyrimidines and (dialkylamino)azabicyclo-nonanes possess activity against protozoan parasites. A series of fused hybrids were synthesized and tested in vitro against pathogens of malaria tropica and sleeping sickness.
Clemens Hinteregger, Johanna Dolensky, Werner Seebacher, Robert Saf, Pascal Mäser, Marcel Kaiser, Robert Weis   +6 more
doaj   +1 more source

Base-Promoted Intramolecular Addition of Vinyl Cyclopropanecarboxamides to Access Conformationally Restricted Aza[3.1.0]bicycles

Molecules, 2023
3-Azabicyclo[3.1.0]hexanes are common structural components in natural products and bioactive compounds. Traditionally, the metal-mediated cyclopropanation domino reaction of chain enzymes is the most commonly used strategy for the construction of this ...
Jingya Li, Zhiguo Zhang, Liming Chen, Mengjuan Li, Xingjie Zhang, Guisheng Zhang   +5 more
doaj   +1 more source

Selective Synthesis of N-Acylnortropane Derivatives in Palladium-Catalysed Aminocarbonylation

Molecules, 2021
The aminocarbonylation of various alkenyl and (hetero)aryl iodides was carried out using tropane-based amines of biological importance, such as 8-azabicyclo[3.2.1]octan-3-one (nortropinone) and 3α-hydroxy-8-azabicyclo[3.2.1]octane (nortropine) as N ...
László Kollár, Ádám Erdélyi, Haroon Rasheed, Attila Takács   +3 more
doaj   +1 more source

Synthesis and Characterization of Two Schiff Base Tetradentate Ligands and their Related Complexes of [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2012
:The compound [H2L1] (2,6-di(phenyl-4-methyl) [3.3.1] azabicyclo-9-2-amino ethylimine) was used to prepare two novel Schiff base ligands 2,4-bis [2,6-di(phenyl-4-methyl)[3.3.1] azabicyclo-9- 2-imine ethylimine] butane [L2] and 2,5-bis [2,6-di(phenyl-4 ...
Mahmoud S. muter
doaj   +1 more source

Optimized synthesis of enantiomeric C9-keto-5-phenylmorphans, essential intermediates for novel MOR agonists and antagonists

Results in Chemistry, 2022
Two modifications of previous procedures enabled the high-yield scalable synthesis of the pharmacologically important enantiomers of a C9-keto-5-phenylmorphan ((1R,5R)- and (1S,5S)-5-(3-methoxyphenyl)-2-methyl-2-azabicyclo[3.3.1]nonan-9-one).
Agnieszka Sulima, Jason A. Deck, Muneaki Kurimura, Arthur E. Jacobson, Kenner C. Rice   +4 more
doaj   +1 more source