Results 11 to 20 of about 1,579,156 (183)
A Novel Class of "Super-Strained" Spiro Heterocycles: Gateway to 1-Azaspiro[3.3]heptane Derivatives, and Biological Validation. [PDF]
Angew Chem Int Ed EnglA new class of “super‐strained” spiro heterocycles—spirocyclic 1‐azabicyclo[1.1.0]butanes—was synthesized via insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into substituted azirines. The stability of this new class of compounds was studied.
Natho P +9 more
europepmc +3 more sources
Strain Release of 1-Azabicyclo[1.1.0]butanes as a Gateway to Highly Functionalized Azetidines: New Strategies and Structural Motifs. [PDF]
ChemistryOver the past decade, the interest in azetidines has continuously risen, by virtue of their highly appealing pharmaceutical properties. Monocyclic, spirocyclic, and bridged azetidines can be accessed by leveraging 1‐azabicyclo[1.1.0]butanes as precursors.
Gelato Y, Natho P, Colella M, Luisi R.
europepmc +2 more sources
Photogenerated Oxetanes as a Gateway to Uphill Cyclopropanation. [PDF]
Angew Chem Int Ed EnglAn atom‐economical route to densely functionalized cyclopropanes from furans and photochemically activated aldehydes is enabled by a unique oxetane‐to‐cyclopropane rearrangement. These cyclopropanes can be used to access complex bioactive scaffolds and serve as a platform for asymmetric cyclopropane synthesis.
Köglmeier T, Tiefel TJ, Reiser O.
europepmc +2 more sources
The Role of Through-Bond Stereoelectronic Effects in the Reactivity of 3-Azabicyclo[3.3.1]nonanes [PDF]
, 2021 Hyperconjugation/conjugation through-bond stereoelectronic effects were studied with density functional theory (DFT) in the context of 3-azabicyclo[3.3.1]nonanes to unravel puzzling differences in reactivity between a vinylogous chloride (4) and a ...
Croix, Laconsay +2 more
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Antiprotozoal Activity of Azabicyclo-Nonanes Linked to Tetrazole or Sulfonamide Cores
Molecules, 2022 N-(Aminoalkyl)azabicyclo[3.2.2]nonanes possess antiplasmodial and antitrypanosomal activity. A series with terminal tetrazole or sulfonamido partial structure was prepared. The structures of all new compounds were confirmed by NMR and IR spectroscopy and
Johanna Dolensky +8 more
doaj +1 more source
) Functionalization of Highly Strained 1‐Azabicyclo[1.1.0]butanes [PDF]
, 2021 Strained compounds are privileged moieties in modern synthesis. In this context, 1-azabicyclo[1.1.0]butanes are appealing structural motifs that can be employed as click reagents or precursors to azetidines.
Renzo Luisi +13 more
core +1 more source
Studies in Bicyclic Compounds [PDF]
, 1967 Part I : Synthetic approaches to allohimachalol 2-(gamma-formylbutyl )-2,6,6-trimethylcycloheptanone was synthesised in six steps from tetrahydroeucarvone.
Wall, Richard Terence
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Synthesis of Analogues of Epibatidine based on the 2-azabicyclo[2.2.1]heptane system
, 2018 Epibatidine (exo-2-(6-chloro-3-pyridyl)-7-azabicyclo[2.2.1]heptane) is an alkaloid isolated from the skin of the Ecuadorian poison frog. It has been known since 1992 and has high binding affinity for nicotinic acetylcholine receptors.
Huda Ismail Al-Rubaye (7773863)
core +7 more sources
Beilstein Journal of Organic Chemistry, 2022 The first synthesis of 2-amino-3,4-dihydroxycyclooctane-1-carboxylic acid, methyl 6-hydroxy-9-oxo-8-oxabicyclo[5.2.1]decan-10-yl)carbamate, and 10-amino-6-hydroxy-8-oxabicyclo[5.2.1]decan-9-one starting from cis-9-azabicyclo[6.2.0]dec-6-en-10-one is ...
İlknur Polat +3 more
doaj +1 more source
Heliyon, 2023 Condensation of quinaldine with 4,6-di (tert-butyl)-3-nitro-1,2-benzoquinone results in the formation of 5,7-di (tert-butyl)-2-(quinoline-2-yl)-1,3-tropolone, 5,7-di (tert-butyl)-4-nitro-2-(quinoline-2-yl)-1,3-tropolone, 3,3-dimethyl-2-(5-hydroxy-4-nitro-
Tatyana A. Krasnikova +12 more
doaj +1 more source