Results 11 to 20 of about 4,192 (189)

Hypervalent organoiodine reagents in the transannular functionalisation of medium-sized lactams: synthesis of 1-azabicyclo compounds

J. Chem. Soc., Chem. Commun., 1989
2 pages, 1 table, 1 scheme.
Dorta, Rosa L., Francisco, Cosme G., Suárez, Ernesto   +2 more
openaire   +3 more sources

Antiprotozoal Activity of Azabicyclo-Nonanes Linked to Tetrazole or Sulfonamide Cores [PDF]

Molecules, 2022
N-(Aminoalkyl)azabicyclo[3.2.2]nonanes possess antiplasmodial and antitrypanosomal activity. A series with terminal tetrazole or sulfonamido partial structure was prepared. The structures of all new compounds were confirmed by NMR and IR spectroscopy and
Johanna Dolensky, Clemens Hinteregger, Andreas Leitner, Werner Seebacher, Robert Saf, Ferdinand Belaj, Pascal Mäser, Marcel Kaiser, Robert Weis   +8 more
doaj   +2 more sources

A convenient synthesis of CHF₂O-containing pyrrolidines and related compounds — Perspective building blocks for drug discovery

SynOpen
Fluorine-containing organic molecules, including CHF2O-derivatives, are among the most sought-after in medicinal chemistry. In the current work, a mini-library of 21 compounds with a CHF2O-motif incorporated with azetidine, pyrrolidine (proline ...
Kostiantyn Levchenko, Ivan Virstiuk, Daria Menshykova, Nazariy Pokhodylo   +3 more
doaj   +2 more sources

) Functionalization of Highly Strained 1‐Azabicyclo[1.1.0]butanes [PDF]

, 2021
Strained compounds are privileged moieties in modern synthesis. In this context, 1-azabicyclo[1.1.0]butanes are appealing structural motifs that can be employed as click reagents or precursors to azetidines.
Renzo Luisi, Kappe, Oliver C, David Cantillo, Timo von Keutz, Leonardo Degennaro, Pantaleo Musci, von Keutz, Timo, Degennaro, Leonardo, Cantillo, David, Musci, Pantaleo, Ferdinand Belaj, Belaj, Ferdinand, C. Oliver Kappe, Luisi, Renzo   +13 more
core   +1 more source

Efficient and regioselective synthesis of dihydroxy-substituted 2-aminocyclooctane-1-carboxylic acid and its bicyclic derivatives

Beilstein Journal of Organic Chemistry, 2022
The first synthesis of 2-amino-3,4-dihydroxycyclooctane-1-carboxylic acid, methyl 6-hydroxy-9-oxo-8-oxabicyclo[5.2.1]decan-10-yl)carbamate, and 10-amino-6-hydroxy-8-oxabicyclo[5.2.1]decan-9-one starting from cis-9-azabicyclo[6.2.0]dec-6-en-10-one is ...
İlknur Polat, Selçuk Eşsiz, Uğur Bozkaya, Emine Salamci   +3 more
doaj   +1 more source

Reaction of quinaldine with 4,6-di(tert-butyl)-3-nitro-1,2-benzoquinone. Dependence of the outcome on the reaction conditions and a deeper insight into the mechanism

Heliyon, 2023
Condensation of quinaldine with 4,6-di (tert-butyl)-3-nitro-1,2-benzoquinone results in the formation of 5,7-di (tert-butyl)-2-(quinoline-2-yl)-1,3-tropolone, 5,7-di (tert-butyl)-4-nitro-2-(quinoline-2-yl)-1,3-tropolone, 3,3-dimethyl-2-(5-hydroxy-4-nitro-
Tatyana A. Krasnikova, Yurii A. Sayapin, Inna O. Tupaeva, Eugeny A. Gusakov, Ilya V. Ozhogin, Anton V. Lisovin, Mikhail V. Nikogosov, Oleg P. Demidov, Duong Nghia Bang, Tran Dai Lam, Nguyen Thi Thu Trang, Alexander D. Dubonosov, Vladimir I. Minkin   +12 more
doaj   +1 more source

Biological Evaluation and Theoretical Study of Bi-dentate Ligand for Amoxicillin Derivative with Some Metal Ions

مجلة بغداد للعلوم, 2021
In this paper, the complexes of Shiff base of Methyl -6-[2-(diphenylmethylene)amino)-2-(4-hydroxyphenyl)acetamido]-2,2-dimethyl-5-oxo-1-thia-4-azabicyclo[3.2.0]heptane-3-carboxylate (L) with Cobalt(II), Nickel(II), Cupper(II) and Zinc(II) have been ...
Sahar S. Hassan, Nidhal M. Hassan, Shaymaa Rajab Baqer, Asmaa M. saleh   +3 more
doaj   +1 more source

Study of Cytotoxicity of Spiro-Fused [3-Azabicyclo[3.1.0]hexane]oxindoles against Tumor Cell Lines

Medical Sciences Forum, 2022
Oncological diseases are one of the most common public health problems and the second leading cause of death after cardiovascular disease. Natural products or synthetic compounds derived from natural products continue to be excellent sources for new drug
Anton A. Kornev, Stanislav V. Shmakov, Alexey S. Klyuchnikov, Alexey V. Artemov, Alexander V. Stepakov, Vitali M. Boitsov   +5 more
doaj   +1 more source

Highly selective synthesis of functionalized morphan derivatives through a multi-component cascade reaction of 3-formylchromones, 2-naphthols, and enaminones

Green Synthesis and Catalysis, 2023
A novel protocol for the preparation of highly functionalized 2-azabicyclo[3.3.1]nonane (morphan) derivatives via a multicomponent cascade reaction, involving 3-formylchromones, 2-naphthols, and enaminones in the ionic liquid [BMIM]PF6 as the solvent and
Xinling Cao, Yinggang Duan, Kaihong Lv, Zihan Lu, Yihua Chen, Shengjiao Yan   +5 more
doaj   +1 more source

The Role of Through-Bond Stereoelectronic Effects in the Reactivity of 3-Azabicyclo[3.3.1]nonanes

, 2021
Hyperconjugation/conjugation through-bond stereoelectronic effects were studied with density functional theory (DFT) in the context of 3-azabicyclo[3.3.1]nonanes to unravel puzzling differences in reactivity between a vinylogous chloride (4) and a ...
Croix, Laconsay, Tyler, Rho, Dean, Tantillo   +2 more
core   +1 more source