Results 31 to 40 of about 1,579,156 (183)

A convenient synthesis of CHF₂O-containing pyrrolidines and related compounds — Perspective building blocks for drug discovery

SynOpen
Fluorine-containing organic molecules, including CHF2O-derivatives, are among the most sought-after in medicinal chemistry. In the current work, a mini-library of 21 compounds with a CHF2O-motif incorporated with azetidine, pyrrolidine (proline ...
Kostiantyn Levchenko, Ivan Virstiuk, Daria Menshykova, Nazariy Pokhodylo   +3 more
doaj   +1 more source

Synthesis and characterization of Novel Schiff bases and evaluation of Corrosion inhibitors and biological activity

مجلة علوم ذي قار, 2019
Novel Schiff bases have been prepared from (6R,7R)-3-[( acetyloxy)methyl]-7-[[( Z)-2-(2aminothiazol-4-yl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]-oct-2-ene-2carboxylate sodium and 2,4-dihydroxy benzaldehyde ,3-methoxy-4-hydroxy
Ahmed M. Jassim
doaj   +4 more sources

Synthesis of 7-azabicyclo [2.2.1]heptane derivatives via bridgehead radicals

, 2002
This report shows the versatility and synthetic potential of 7-azabicyclo[2.2.1]heptane-1-carboxylic acid (Ahc) to obtain several bridgehead 1-substituted-7-azabicyclo[2.2.1]heptane derivatives, including halogen derivatives, via bridgehead radical ...
Peregrina, J.M. [0000-0003-3778-7065], Avenoza, A. [0000-0002-5465-3555], Busto, J.H. [0000-0003-4403-4790], Cativiela, C.   +3 more
core   +1 more source

Synthesis and Nicotinic Acetylcholine Receptor Binding Properties of exo-2-(2‘-Fluoro-5‘-pyridinyl)-7-azabicyclo- [2.2.1]heptane:  A New Positron Emission Tomography Ligand for Nicotinic Receptors

, 2016
Synthesis and Nicotinic Acetylcholine Receptor Binding Properties of exo-2-(2‘-Fluoro-5‘-pyridinyl)-7-azabicyclo- [2.2.1]heptane:  A New Positron Emission Tomography Ligand for Nicotinic ...
Philip Abraham (2180182), Nora Volkow (3020373), Feng Liang (447805), Hernán A. Navarro (2447089), Michael J. Kuhar (2483143), Pravin Kotian (3010884), Yu-Shin Ding (3020376), F. Ivy Carroll (445446), Joanna Fowler (3020379)   +8 more
core   +1 more source

New Synthesis of 7-azabicyclo[2.2.1]heptane-1-carboxylic acid [PDF]

, 2001
This report describes a new synthetic route to 7-azabicyclo[2.2.1]heptane-1-carboxylic acid (Ahc), a constrained proline analogue, in which the key step is the Diels-Alder reaction using methyl 2-benzamidoacrylate as dienophile.
Peregrina, J.M. [0000-0003-3778-7065], Avenoza, A. [0000-0002-5465-3555], Busto, J.H. [0000-0003-4403-4790], Rodríguez, F., Fernández-Recio, M.A. [0000-0001-8264-1984], Cativiela, C.   +5 more
core   +1 more source

Borylcyclopropanes: Synthetic Strategies and Applications

Angewandte Chemie, Volume 138, Issue 37, 7 September 2026.
Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley   +2 more sources

2,4-Bis(2-methylphenyl)-3-azabicyclo[3.3.1]nonan-9-one O-methyloxime

Acta Crystallographica Section E, 2010
The molecule of the title compound, C23H28N2O, exists in a twin-chair conformation, with equatorial orientation of the ortho-tolyl groups on both sides of the secondary amino group. The title oxime compound and its ketone precursor 2,4-bis(2-methylphenyl)
P. Parthiban, V. Ramkumar, Yeon Tae Jeong   +2 more
doaj   +1 more source

1‐Azabicyclo[1.1.0]butanes (ABBs) on the Map: Mechanistic Pathways for Catalytic Ring Opening and Functionalizations

Angewandte Chemie International Edition, EarlyView.
Catalytic strain‐release ring opening and functionalizations of 1‐azabicyclo[1.1.0]butanes (ABBs) represent a promising strategy for accessing diverse azetidine products. These transformations proceed via polar pathways, radical pathways, and hybrid mechanisms that combine both.
James Shao‐Jiun Yang, Hsuan‐Hung Liao   +1 more
wiley   +1 more source

Copper-Catalyzed Tandem Cross-Coupling/[2 + 2] Cycloaddition of 1,6-Allenynes with Diazo Compounds to 3‑Azabicyclo[5.2.0] Ring Systems

, 2019
An unprecedented copper-catalyzed tandem cross-coupling/[2 + 2] cycloaddition of 1,6-allenynes with diazo compounds was reported, chemo- and regioselectively providing 3-azabicyclo[5.2.0] frameworks in moderate to excellent yields under mild reaction ...
Shiyong Peng (1508452), Qing Li (84975), Nuan Chen (6851615), Ting Zhou (38572), Jian Wang (5901), Min He (44052), Ming Lang (3757117), Hongguang Li (829886)   +7 more
core   +1 more source

Domino reactions of 2H-azirines with acylketenes from furan-2,3-diones: Competition between the formation of ortho-fused and bridged heterocyclic systems

Beilstein Journal of Organic Chemistry, 2014
3-Aryl-2H-azirines react with acylketenes, generated by thermolysis of 5-arylfuran-2,3-diones, to give bridged 5,7-dioxa-1-azabicyclo[4.4.1]undeca-3,8-diene-2,10-diones and/or ortho-fused 6,6a,12,12a-tetrahydrobis[1,3]oxazino[3,2-a:3′,2′-d]pyrazine-4,10 ...
Alexander F. Khlebnikov, Mikhail S. Novikov, Viktoriia V. Pakalnis, Roman O. Iakovenko, Dmitry S. Yufit   +4 more
doaj   +1 more source