Results 31 to 40 of about 7,278 (228)

Studies on 1-Azabicyclo Compounds. XXV. Synthesis of Nine-membered Ring Aminolactams and Related Compounds from Octahydropyrrolo[1, 2-α]pyrazin-1-one

YAKUGAKU ZASSHI, 1975
Hideo Kato
openalex   +4 more sources

7-Azabicyclo[2.2.1]heptane N-Imide as an Intermediate in the Thermal Decomposition of N-Amino-7-Azabicyclo[2.2.1]heptane and the Corresponding Benzenesulphonamide [PDF]

, 1976
An intermediate in the thermal decomposition of N-amino-7-azabicyclo[2.2.1]heptane and the corresponding benzenesulphonamide derivative, whose structure is consistent with the formulation 7-azabicyclo[2.2.1]heptane N-imide, affords on thermal ...
Dervan, Peter B., Uyehara, Tadao
core   +1 more source

Synthesis, Theoretical Study, and Biological Evaluation of Some Metal Ions with Ligand "Methyl -6-[2-(4-Hydroxyphenyl) -2-((1-Phenylethylidene) Amino) Acetamido] -2,2-Dimethyl-5—Oxo-1-Thia-4-Azabicyclo [3.2.0] Heptane-3-Carboxyylate

مجلة بغداد للعلوم, 2023
Schiff base (methyl 6-(2- (4-hydroxyphenyl) -2- (1-phenyl ethyl ideneamino) acetamido) -3, 3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylate)Co(II), Ni(II), Cu (II), Zn (II), and Hg(II)] ions were employed to make certain complexes ...
Sahar S. Hassan, Nafeesa J. Kadhim , Zahraa. A. Jaber   +2 more
doaj   +1 more source

Unexpected Resistance to Base-Catalyzed Hydrolysis of Nitrogen Pyramidal Amides Based on the 7-Azabicyclic[2.2.1]heptane Scaffold

Molecules, 2018
Non-planar amides are usually transitional structures, that are involved in amide bond rotation and inversion of the nitrogen atom, but some ground-minimum non-planar amides have been reported.
Diego Antonio Ocampo Gutiérrez de Velasco, Aoze Su, Luhan Zhai, Satowa Kinoshita, Yuko Otani, Tomohiko Ohwada   +5 more
doaj   +1 more source

Exploration of bivalent ligands targeting putative mu opioid receptor and chemokine receptor CCR5 dimerization [PDF]

, 2016
Modern antiretroviral therapies have provided HIV-1 infected patients longer lifespans and better quality of life. However, several neurological complications are now being seen in these patients due to HIV-1 associated injury of neurons by infected ...
Arnatt, Christopher K., El-Hage, Nazira, Falls, Bethany A., Hauser, Kurt F., Knapp, Pamela E., Masvekar, Ruturaj R., Nicola, Anthony V., Raborg, Thomas J., Selley, Dana E., Yuan, Yunyun, Zhang, Yan   +10 more
core   +2 more sources

Discovery of a Potent Highly Biased MOR Partial Agonist among Diastereomeric C9-Hydroxyalkyl-5-phenylmorphans

Molecules, 2023
All possible diastereomeric C9-hydroxymethyl-, hydroxyethyl-, and hydroxypropyl-substituted 5-phenylmorphans were synthesized to explore the three-dimensional space around the C9 substituent in our search for potent MOR partial agonists.
Joshua A. Lutz, Agnieszka Sulima, Eugene S. Gutman, Eric W. Bow, Dan Luo, Sophia Kaska, Thomas E. Prisinzano, Carol A. Paronis, Jack Bergman, Gregory H. Imler, Andrew T. Kerr, Arthur E. Jacobson, Kenner C. Rice   +12 more
doaj   +1 more source

Exploration of Novel Mono Hydroxamic Acid Derivatives as Inhibitors for Histone Deacetylase Like Protein (HDLP) by Molecular Dynamics Studies

Indonesian Journal of Chemistry, 2022
The acetylation modification process of histone has an essential role in the epigenetic regulation of gene expression. This process is controlled by the balance between histone deacetylases (HDAC) and histone acetyltransferases (HAT).
Gunasingham Parthiban, Ramachandren Dushanan, Samantha Weerasinghe, Dhammike Dissanayake, Rajendram Senthilnithy   +4 more
doaj   +1 more source

Performance of the ALOGPS 2.1 program for octanol-water partition coefficient prediction with organic chemicals on the Canadian Domestic Substances List [PDF]

, 2010
The KOWWIN and ALOGPS octanol-water partition coefficient (K~ow~) estimation software programs were compared for their capacity to accurately predict log K~ow~ values of 1545 organic compounds on the publicly available Domestic Substances List (DSL) from
Kaya Forest, Sierra Rayne
core   +2 more sources

Ring closure reactions of bicyclic prolinol and prolin ester enantiomers [PDF]

, 2009
Starting from the of bicyclic proline ester, ethyl exo-2-azabicyclo[2.2.1]heptane-3-carboxylate (+)-5 several hydantoines and thiohydantoines were prepared by acidic ring closure of the corresponding urea or thiourea derivatives. Enantiomer (-)-5 was
Fülöp, Ferenc, Kivela, H., Molnar, Zs., Palkó, Márta, Pihlaja, K., Sinnkonen, J.   +5 more
core   +1 more source

Synthesis of (−)-epibatidine [PDF]

, 2014
An asymmetric synthesis to the dendrobatid alkaloid (−)-epibatidine has been described, featuring chiral resolution of both optically pure 7-azabicyclo[2.2.1]heptanecarboxylic acid, and subsequent transformations to (−)-epibatidine.
Chiang, Yu-Min, Chiou, Wen-Hua
core   +1 more source