Results 41 to 50 of about 1,579,156 (183)
A Unified Approach for the Synthesis of Conformationally Locked and sp2‐sp3 Fused Hybrids
Chemistry – A European Journal, EarlyView.This study presents a systematic platform to build rigid sp2–sp3 hybrids via benzyne cycloadditions. Arene‑fused bicyclic oxa‐, aza‐, and carbocycles are converted into medicinally relevant amino acids and applied to Enalapril analogues synthesis. The hybrids combine aromatic interactions with 3D rigidity, tuning lipophilicity, pKa, and solubility ...
Ervis Saraci +8 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2015 This paper reports the synthesis of a series of piperidones 1–8 by the Mannich reaction and analysis of their structures and conformations in solution by NMR and mass spectrometry.
Cesar Garcias-Morales +2 more
doaj +1 more source
Designing a Triplet 2‐Formylphenylnitrene With Fast Tunneling Reactivity
Chemistry – A European Journal, EarlyView.A 3‐CF3 substituent accelerates tunneling in triplet 2‐formylphenylnitrene, making its reactivity in cryogenic matrices too fast for conventional IR spectroscopic detection. Bringing this chemistry to low‐temperature solutions allows suppression of intrinsic nitrene dimerization through faster cyclization, which even outcompetes the 1,4‐H shift ...
Sofia Braz +4 more
wiley +1 more source
Strain‐Release‐Driven Friedel‐Crafts Spirocyclization of Azabicyclo[1.1.0]butanes [PDF]
, 2022 The identification of spiro N-heterocycles as scaffolds that display structural novelty, three-dimensionality, beneficial physicochemical properties, and enable the controlled spatial disposition of substituents has led to a surge of interest in ...
Aggarwal, Varinder K. +6 more
core +1 more source
Synthetic Strategies for the Construction of Cyclobutane‐Fused Heterocycles
European Journal of Organic Chemistry, EarlyView.Cyclobutane‐fused heterocycles are important motifs commonly present in bioactive compounds, recognized for their rigid 3D structures that confer unique properties. However, synthesizing these compounds remains challenging. This review discusses current methods for their synthesis, such as photochemical, metal‐catalyzed, and Lewis acid‐mediated [2 + 2]
Michela Vargiu +2 more
wiley +1 more source
, 1979 The synthesis of N-ethoxycarbonyl-7-azabicyclo[4.2.1]nonane and iV-ethoxycarbonyl-9-azabicyclo[4.2.1]nonane, starting from bicyclo[5.1.0]octan- 2-one, is described.
PELLACANI, Lucio +2 more
core +1 more source
The continuing significance of chiral agrochemicals
Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley +1 more source
, 2019 To explore a new skeleton with nematicidal activity, a series of novel azabicyclo derivatives containing a thiazole moiety were designed, synthesized and evaluated for their nematicidal activities.
Aoyun Lu (8171343) +4 more
core +1 more source
British Journal of Pharmacology, Volume 183, Issue 19, Page 5871-5894, October 2026.A pharmacological profiling of 58 synthetic stimulants of various classes at dopamine, norepinephrine, and serotonin transporters and the 5‐HT2A receptor, most showing distinct class‐dependent profiles, with some indicating a high abuse potential. Background and Purpose New psychoactive substances (NPSs) often emerge on the illicit drug market with ...
Darta Stalberga +9 more
wiley +1 more source
)‐2‐Substituted‐1‐azabicyclo[2.2.1]heptanes
, 2009 The first stereoselective synthesis of two diastereomeric 1-azabicyclo[2.2.1]heptanes substituted at the 2-position from an easily accessible (R)-2-substituted-4-piperidone is reported.
Ramón Badorrey +7 more
core +1 more source