Novel interstrand communication systems within DNA duplexes based on 1-, 2- and 4-(phenylethynyl)pyrenes attached to 2′-amino-LNA: high-affinity hybridization and fluorescence sensing [PDF]
, 2010 Functionalisation of 2′-amino-LNA oligonucleotides with 1-, 2- and 4-(phenylethynyl)pyrene fluorophores via a carbonyl linker (PEPyc) resulted in efficient interstrand communication systems in nucleic acid duplexes, providing effective tools for ...
Astakhova, Irina +3 more
core +1 more source
Lysosomal membrane permeabilization is an early event in sigma-2 receptor ligand mediated cell death in pancreatic cancer [PDF]
, 2012 BACKGROUND: Sigma-2 receptor ligands have been studied for treatment of pancreatic cancer because they are preferentially internalized by proliferating cells and induce apoptosis.
Abate, Carmen +7 more
core +2 more sources
Synthetic Strategies for the Construction of Enantiomeric Azanoradamantanes [PDF]
, 1997 The amino azanoradamantane hexahydro-2,5b-methano-IH-3aS,3aa,6aa-cyclopenta-[clpyrrole-4a-amine 1and the corresponding enantiomer ent-1 have been prepared along with benzamide derivatives SC-52491and SC-52490, respectively, which are of pharmaceutical ...
Becker, Daniel +3 more
core +1 more source
SynOpenFluorine-containing organic molecules, including CHF2O-derivatives, are among the most sought-after in medicinal chemistry. In the current work, a mini-library of 21 compounds with a CHF2O-motif incorporated with azetidine, pyrrolidine (proline ...
Kostiantyn Levchenko +3 more
doaj +1 more source
A Complex Stereochemical Relay Approach To The Antimalarial Alkaloid Ocimicide A1. Evidence For A Structural Revision [PDF]
, 2017 Ocimicide A1 (1) and the semisynthetic derivative ocimicide A2 (2) are highly potent antimalarial agents efficacious against chloroquine-sensitive and -resistant Plasmodium falciparum strains with IC50 values in the nanomolar and picomolar range ...
Herzon, S. B. +4 more
core +2 more sources
مجلة علوم ذي قار, 2019 Novel Schiff bases have been prepared from (6R,7R)-3-[( acetyloxy)methyl]-7-[[( Z)-2-(2aminothiazol-4-yl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]-oct-2-ene-2carboxylate sodium and 2,4-dihydroxy benzaldehyde ,3-methoxy-4-hydroxy
Ahmed M. Jassim
doaj +4 more sources
Anomeric Amides: Valuable Reagents in Synthetic Organic Chemistry
Angewandte Chemie, Volume 138, Issue 12, 16 March 2026.Enabling late‐stage transformations and skeletal editing, anomeric amides have recently emerged as powerful synthetic tools. Due to their unique properties, anomeric amides have been employed in reactions ranging from amination to halogenation. This minireview provides an overview of recent progress in using anomeric amides across a variety of ...
Arushi Garg +3 more
wiley +2 more sources
Asymmetric cyclopropanation of conjugated cyanosulfones using a novel cupreine organocatalyst: rapid access to d3-amino acids [PDF]
, 2015 An organocatalytic asymmetric synthesis of a novel, highly functionalised cyclopropane system furnished with versatile substituents and containing a quaternary centre is described.
Aitken, Lewis S. +5 more
core +1 more source
Desymmetrization of meso-Dibromocycloalkenes through Copper(I)-Catalyzed Asymmetric Allylic Substitution with Organolithium Reagents [PDF]
, 2018 The highly regio- and enantioselective (up to >99:1 dr, up to 99:1 er) desymmetrization of meso-1,4-dibromocycloalk-2-enes using asymmetric allylic substitution with organolithium reagents to afford enantioenriched bromocycloalkenes (ring size of 5 to 7)
Feringa, Ben L +6 more
core +1 more source
Photochemistry of Aromatic N‐Oxides in Water Probed by Time‐Resolved X‐ray Absorption Spectroscopy
Chemistry – A European Journal, EarlyView.Time‐resolved XAS at the nitrogen and oxygen K‐edges is applied to the photorearrangement of two N‐oxides in water. Pyridine N‐oxide rapidly forms the oxaziridine isomer. Pyridazine N‐oxide undergoes ring opening to the diazo compound, without any evidence of intermediates.
Maximilian Paradiz Domínguez +3 more
wiley +1 more source