Results 61 to 70 of about 1,579,156 (183)

A Concise Approach to 2-Azabicyclo[3.3.1]nonane Derivatives from an Acyclic Precursor

, 2016
Condensation of a readily available 5-amino-2-alkenoate ester with α-unsubstituted aliphatic aldehydes leads to substituted 1,2,3,4-tetrahydropyridines. Subsequent manipulation of the ester and enamine functions gives a quick access to 2-azabicyclo[3.3.1]
José M. Gorgojo (2664220), José M. Aurrecoechea (2440651), Carlos Saornil (2664223)   +2 more
core   +1 more source

Studies on 1-Azabicyclo Compounds. XVI. Synthesis of 1'-Methylindan-2-spiro-2'-piperazine and Related Compounds

Chemical and Pharmaceutical Bulletin, 1973
A new synthesis of the spirodiamines (IIIa-c) from the methiodides (Ia-c) via the spiroaminolactams (VIIa-c) by Stevens rearrangement is described.
KATO, HIDEO, KOSHINAKA, EIICHI, ARATA, YOSHIO, HANAOKA, MIYOJI   +3 more
openaire   +2 more sources

Synthesis of Novel 2-Azabicyclo[2.2.0]- and [2.1.1]hexanols

, 2016
Methyl- and phenyl-substituted N-(ethoxycarbonyl)-2-azabicyclo[2.2.0]hex-5-enes 6 were reacted with NBS in wet DMSO to afford bromohydrins. Mixtures of unrearranged 6-exo-bromo-5-endo-hydroxy-2-azabicyclo[2.2.0]hexanes 7a,b and rearranged 5-anti-bromo-6 ...
Grant R. Krow (1266600), Jing Yuan (217967), Jingqi Duo (2700319), Kevin Cannon (3027267), Walden S. Lester (3027264), Nian Liu (29935), Amanda Hiller (3027270), Seth B. Herzon (1319394), Yen Nguyen (1500718)   +8 more
core   +2 more sources

The antiprotozoal potencies of newly prepared 3-azabicyclo[3.2.2]nonanes

, 2016
3-Azabicyclo[3.2.2]nonanes are already reported as antiprotozoal agents. Structural variations were performed by attachment of several basic side chains, being part of drugs in use, to the ring nitrogen.
Faist, Johanna, Kaiser, Marcel, Brun, Reto, Weis, Robert, Ahmad, Sarfraz, Seebacher, Werner, Saf, Robert   +6 more
core   +1 more source

An alkaloid-like 3-azabicyclo[3.3.1]non-3-ene library obtained from the bridged Ritter reaction [PDF]

, 2017
© 2016 Elsevier Ltd A small, diverse library of novel alkaloid-like compounds was synthesised using the bridged Ritter reaction with (−)-β-pinene and subsequent scaffold derivatisation. Structural diversity was achieved by varying the nitrile used in the
Williams, SG, Bhadbhade, M, Ung, AT, Bishop, R   +3 more
core   +1 more source

2-Azabicyclo[2.1.1]hexanes. 2. Substituent Effects on the Bromine-Mediated Rearrangement of 2-Azabicyclo[2.2.0]hex-5-enes

, 2016
Methyl- and phenyl-substituted N-(ethoxycarbonyl)-2-azabicyclo[2.2.0]hex-5-enes 6 have been prepared by photoirradiation of appropriately substituted 1,2-dihydropyridines.
Grant R. Krow (1266600), Jing Yuan (217967), Jingqi Duo (2700319), Yoon B. Lee (3027258), Walden S. Lester (3027264), Nian Liu (29935), Seth B. Herzon (1319394), Yen Nguyen (1500718), David Zacharias (3027261)   +8 more
core   +2 more sources

3-thia-7-azabicyclo(3.3.L)Nonanes and Derivatives as Antiarrhythmic Agents

, 1982
3-Thia-7-azabicyclo(3.3.1)nonanes and derivatives thereof are disclosed. The preparation of these compounds is given.

core  

2-Azabicyclo[2.2.1]hept-5-enes from 7-azabicyclo[2.2.1]heptadienes by tandem intermolecular radical addition-homoallylic radical rearrangement

, 2001
Addition of thiols to 7-azabicyclo[2.2.1]heptadienes such as 16 leads exclusively to 7-thio-substituted 2-azabicyclo[2.2.1]hept-5-enes 17 in good yields via tandem intermolecular radical addition - homoallylic radical ...
Hodgson, David M., Hodgson, DM, Bebbington, MWP, Hodgson, David, Willis, Paul, Willis, P, Paul Willis, Bebbington, Magnus, David M. Hodgson, Magnus W. P. Bebbington   +9 more
core   +1 more source

Formation of 3-azabicyclo[3.3.1]non-3-enes: Imino amides vs. imino alkenes

, 2014
An effective method for synthesising alkaloid-like compounds containing the 3-azabicyclo[3.3.1]non-3-ene core structure was successfully carried out in a stereoselective manner via the bridged-Ritter reactions.
Williams, SG, Ung, AT, Bhadbhade, M, Bishop, R, Angeloski, A, Kuzhiumparambil, U, Ashmore, J   +6 more
core   +1 more source

Design and synthesis of 6-substituted amino-4-oxa-1-azabicyclo[3,2,0]heptan-7-one derivatives as cysteine protease inhibitors

, 2002
A series of 6-substituted amino-4-oxa-1-azabicyclo[3,2,0]heptan-7-one compounds was designed and synthesized as a new class of inhibitors for cysteine proteases cathepsins B, L, K, and S.
Kaleta, Jadwiga, M\ue9nard, Robert, Zhou, Nian E., Micetich, Ronald G., Singh, Rajeshwar, Guo, Deqi, Purisima, Enrico   +6 more
core   +1 more source