Results 51 to 60 of about 1,579,156 (183)

Modified Synthesis of Four Kinds of Azabicyclo Compounds

Chinese Journal of Applied Chemistry, 2012
Azabicyclo compounds of 1,4-benxodiazine,pyridopyrazine,1H-benzimidazole,3H-imidazopyridine were prepared from o-phenylenediamine or 2,3-diaminopyridine reacted with carbonyl compounds.The effects of reaction medium,pH,time and other factors on the reactions were invesitigated.The results showed that the yield of pyridopyrazine could reach 89.4% when ...
openaire   +1 more source

The Cyano‐Diels–Alder Reaction: From Nitrile Activation to Functional Molecular Architectures

European Journal of Organic Chemistry, Volume 29, Issue 34, 11 September 2026.
This Concept Article presents the evolution of the cyano‐Diels–Alder reaction from its early examples to its current development as a valuable synthetic tool for the preparation of N‐heterocycles, fused polycycles and functional chromophores, tracing the key breakthroughs that have transformed this underexplored transformation into a relevant platform ...
Giovanni Bottari
wiley   +1 more source

Hypervalent organoiodine reagents in the transannular functionalisation of medium-sized lactams: synthesis of 1-azabicyclo compounds

, 1989
2 pages, 1 table, 1 scheme.The amidyl radical intermediates, produced by photolysis of medium-sized lactams 7-heptanelactam (1), 8-octanelactam (3), and 9-nonanelactam (6) in the presence of (diacetoxyiodo)benzene (DIB) and iodine, undergo transannular ...
Francisco, Cosme G., Suárez, Ernesto, Dorta, Rosa L.   +2 more
core   +1 more source

Functional Activity of Enantiomeric Oximes and Diastereomeric Amines and Cyano Substituents at C9 in 3-Hydroxy-N-phenethyl-5-phenylmorphans

Molecules
The synthesis of stereochemically pure oximes, amines, saturated and unsaturated cyanomethyl compounds, and methylaminomethyl compounds at the C9 position in 3-hydroxy-N-phenethyl-5-phenylmorphans provided μ-opioid receptor (MOR) agonists with varied ...
Hudson G. Roth, Madhurima Das, Agnieszka Sulima, Dan Luo, Sophia Kaska, Thomas E. Prisinzano, Andrew T. Kerr, Arthur E. Jacobson, Kenner C. Rice   +8 more
doaj   +1 more source

1-(Aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(Aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes: A New Series of Potent and Selective Triple Reuptake Inhibitors

, 2016
The discovery of new highly potent and selective triple reuptake inhibitors is reported. The new classes of 1-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes are described together with detailed ...
Anna Checchia (2309827), Kevin D. Read (165019), Elettra Fazzolari (2309830), Doug Minick (2309836), Silvia Terreni (2259541), Filippo Visentini (2309824), Laura Zonzini (2276413), Beatrice Oliosi (2238013), Roberto Arban (2276407), Michela Bettati (2309821), Giorgio Bonanomi (2309833), Silvia Davalli (1572370), Barbara Bertani (2259538), Stefano Fontana (584175), Alessandro Zocchi (2309812), Michele Negri (2309818), Ilaria Sartori (2276422), Luca Tarsi (2259532), Romano Di Fabio (1676758), Paolo Cavanni (2276404), Letizia Bettelini (2309815), Fabrizio Micheli (2259514), Simone Braggio (2259517), Carla Marchioro (2065366), Roberto Benedetti (2309809), Giovanna Tedesco (2259508)   +25 more
core   +1 more source

Transition Metal‐Free Vinylcyclopropanation of Olefins via Carbolithiation Reactions: Synthesis of 3‐Azabicyclo[3.1.0]hexanes

Advanced Synthesis &Catalysis, Volume 368, Issue 17, 1 September 2026.
Readily accessible N‐allyl‐N‐2‐bromoallylamines undergo a tandem lithiation–cyclization cascade to furnish highly substituted 3‐azabicyclo[3.1.0]hexanes. The transformation proceeds without transition metals and delivers products with excellent diastereocontrol across a broad substrate range.
Nuria Cases, Marta Solas, M. Pilar Castroviejo, Samuel Suárez‐Pantiga, Miguel A. Rodríguez, Roberto Sanz   +5 more
wiley   +1 more source

Phosphorylation of 2-azabicyclo[2.2.1]hept-5-ene and 2-hydroxy-2-azabicyclo[2.2.1]hept-5-ene systems: synthesis and mechanistic study

, 2010
The endo and exo isomers of (+/-)-methyl 2-hydroxy-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylates and the in situ-prepared endo and exo isomers of (+/-)-methyl 2-azabicyclo[2.2.1]hept-5-ene-3-carboxylate were treated with diphenylphosphinic chloride ...
Carlos A D Sousa, Luisa L C Vale, Xerardo Garcia Mera, Xerardo García-Mera, Carlos A. D. Sousa, José E. Rodríguez-Borges, Jose E Rodriguez Borges, M. Luísa C. Vale   +7 more
core   +1 more source

Cobalt/Photoredox Catalyzed Desymmetrization of Oxo and Azabicycles via Asymmetric Reductive Coupling With Alkynes

Advanced Science, Volume 13, Issue 52, 18 September 2026.
A one‐step, asymmetric reductive coupling of alkynes and oxa‐ and aza‐bicyclic olefins using a cobalt/photoredox catalytic system through desymmetrization. ABSTRACT Bicyclo[2.2.1]heptane frameworks represent a privileged structural motif prevalent in numerous natural products and bioactive molecules.
Subhankar Pradhan, Arko Saha, Bholanath Maity, Sayan Dutta, Luigi Cavallo, Basker Sundararaju   +5 more
wiley   +1 more source

Investigations Into the Metabolism and Elimination of Tesofensine in Human Urine

Drug Testing and Analysis, Volume 18, Issue 9, Page 1163-1173, September 2026.
This study investigated tesofensine metabolism and urinary elimination after a single 483 μg intake via a dietary supplement. In six volunteers, urine was collected up to 659 h. LC‐HRMS/MS identified four tentative metabolites; maximum urinary concentrations reached 4 ng/mL within 4–48 h.
O. Krug, A. Thomas, M. Thevis
wiley   +1 more source

Retro‐Hetero‐Michael Addition Strategies in Organic Synthesis

European Journal of Organic Chemistry, Volume 29, Issue 32, 24 August 2026.
In this review, synthetic approaches to carbo‐ and heterocyclic compounds, including natural products, published in the last 15 years (2011–2025) which have either relied upon or included a retro‐hetero‐Michael addition step at any stage are discussed.
Dina Scarpi, Ernesto G. Occhiato
wiley   +1 more source