Radical Retrosynthesis of Natural Products Enabled by Iron‐Based Reductive Olefin Coupling
Angewandte Chemie Novit, Volume 2, Issue 1, March 2026.This review highlights iron‐catalyzed reductive olefin coupling (ROC)—a strategy for C─C bond formation driven by metal‐hydride hydrogen atom transfer (MHAT)—as a key tool in natural products synthesis. This review surveys dozens of total syntheses employing ROC‐based strategies, highlighting its power to forge strained rings, quaternary centers, and ...
Griffin L. Barnes +2 more
wiley +1 more source
Biomedical Chromatography, Volume 40, Issue 3, March 2026.ABSTRACT Veratrum L. species have been used in traditional medicine for centuries due to their bioactive properties, yet they also contain toxic steroid alkaloids that pose potential health risks when present in herbal preparations. Reliable analytical approaches are therefore essential to ensure product safety, protect consumer health and assess ...
Julia Siegle, Jörg Pietsch
wiley +1 more source
Conjugate addition of 2-(bromomethyl)- and 2-(2-bromoethyl)piperidine to alkyl acrylates : application towards the synthesis of 2-(methoxycarbonyl)indolizidine [PDF]
, 2009 Conjugate addition of 2-(bromomethyl)- and 2-(2-bromoethyl)piperidine hydrobromide to methyl and ethyl acrylate in the presence of triethylamine afforded the corresponding 3-[2-(bromomethyl)piperidin-1-yl]propanoates and 3-[2-(2-bromoethyl)piperidin-1-yl]
Abbaspour Tehrani, Kourosch +3 more
core +2 more sources
Making Blank Faces Expressive: Chemical Approaches to the Modification of Chemically Inert Peptides
Journal of Peptide Science, Volume 32, Issue 3, March 2026.As an alternative to the conventional approach, which combines amino acid monomers in a one‐by‐one fashion to peptide derivatives, the chemical modification of existing peptides has attracted significant attention in recent years. However, such approaches generally target the reactive functional groups in cysteine and lysine residues, particularly in ...
Yoshitaka Moriyama +2 more
wiley +1 more source
Pramanicin analog induces apoptosis in human colon cancer cells: critical roles for Bcl-2, Bim, and p38 MAPK signaling [PDF]
, 2013 Pramanicin (PMC) is an antifungal agent that was previously demonstrated to exhibit antiangiogenic and anticancer properties in a few in vitro studies. We initially screened a number of PMC analogs for their cytotoxic effects on HCT116 human colon cancer
Başağa, Hüveyda +5 more
core +1 more source
Results of GC–MS Analyses of 40 Extracts of Diabetes Devices
Contact Dermatitis, Volume 94, Issue 3, Page 234-244, March 2026.Forty acetone extracts of 27 diabetes devices were investigated by gas chromatography–mass spectrometry. Two hundred eighty four individual chemicals were identified. All 40 extracts contained one or more chemicals that were previously identified as allergens in diabetes devices causing allergic Contact Dermatitis.
Emma M. van Oers +4 more
wiley +1 more source
Peptides binding cocaine: A strategy to design biomimetic receptors [PDF]
, 2013 A computational methodology for designing and rationalizing the selection of small peptides as biomimetic receptors for cocaine is proposed. The method started by searching and filtering proteins X-ray and NMR data of biological receptor-cocaine ...
Compagnone, Dario +6 more
core +1 more source
Harnessing Carbenoid Reactivity From Imidazoles and Oxiranes
Advanced Synthesis &Catalysis, Volume 368, Issue 4, 17 February 2026.The combination of azole compounds and oxiranes exhibits carbenoid reactivity at elevated temperatures, as demonstrated by the successful benzoin condensation of aromatic aldehydes. Using this catalytic system to polymerize bifunctional aldehyde/oxirane monomers yields thermosets with glass transition temperatures above 100°C.
Matthias R. Steiner +4 more
wiley +1 more source
Photo-inhibition Effect from Strong Electron Withdrawing Nitro Group in N-[(E)(4-Bromophenyl)Methylidene]-4 Nitroaniline [PDF]
, 2016 Light induced effect of N-[(E)-(4-bromophenyl)methylidene]-4nitroaniline was investigated using UV-Vis spectrophotometer. This study revealed that the presence of strong electron withdrawing nitro group inhibited the photo-reactivity of the compound ...
Lutfor, M. R. +3 more
core
Identification of T. gondii myosin light chain-1 as a direct target of TachypleginA-2, a small-molecule inhibitor of parasite motility and invasion [PDF]
, 2014 This work was supported by US Public Health Service grant AI054961 (GEW/NJW), a University Research Fellowship from the Royal Society (NJW) and funding for the mass spectrometry analysis was provided by the Vermont Genetics Network/NIH Grant 8P20GM103449
Ballif, B.A. +7 more
core +3 more sources