Results 71 to 80 of about 4,192 (189)

Structural study of (±) alkyl 3-hydroxy-1-azabicyclo [2.2.2] octane-3-carboxylates

, 2013
A series of α-hydroxyesters derived from (±) 3-hydroxy-l-azabicyclo[2.2.2]octane-3-carboxylic acid was synthesised and studied by IR and NMR spectroscopy.
Fonseca, Isabel M., Arias-Pérez, M. S., Sanz-Aparicio, J., Bellanato, Juana   +3 more
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1-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes:a new series of potent and selective triple reuptake inhibitors

, 2010
The discovery of new highly potent and selective triple reuptake inhibitors is reported. The new classes of 1-(ary1)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes are described together with detailed ...
Read, Kevin D., Checchia, Anna, Marchioro, Carla, Bonanomi, Giorgio, Davalli, Silvia, Negri, Michele, Fazzolari, Elettra, Di Fabio, Romano, Sartori, Ilaria, Tedesco, Giovanna, Terreni, Silvia, Zocchi, Alessandro, Bettati, Michela, Braggio, Simone, Cavanni, Paolo, Micheli, Fabrizio, Bettelini, Letizia, Benedetti, Roberto, Minick, Doug, Bertani, Barbara, Oliosi, Beatrice, Arban, Roberto, Visentini, Filippo, Fontana, Stefano, Tarsi, Luca, Zonzini, Laura   +25 more
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Derivatives of (−)-7-Methyl-2-(5-(pyridinyl)pyridin-3-yl)-7-azabicyclo[2.2.1]heptane Are Potential Ligands for Positron Emission Tomography Imaging of Extrathalamic Nicotinic Acetylcholine Receptors

, 2016
A series of novel racemic 7-methyl-2-(5-(pyridinyl)pyridin-3-yl)-7-azabicyclo[2.2.1]heptane derivatives with picomolar in vitro binding affinity at nicotinic acetylcholine receptors (nAChRs) were synthesized and their enantiomers were resolved by ...
Hiroto Kuwabara (672675), Daniel P. Holt (2481040), Mohab Alexander (2481037), Anil Kumar (105720), Hayden T. Ravert (2481043), John Hilton (2424955), Dean F. Wong (672684), Yongjun Gao (757231), Robert F. Dannals (757237), Andrew G. Horti (757238), Christopher J. Endres (79769)   +10 more
core   +1 more source

Enantioselective Access to 3‑Azabicyclo[3.1.0]hexanes by Cp^xRh^III Catalyzed C–H Activation and Cp*Ir^III Transfer Hydrogenation

, 2022
Rigid saturated nitrogen-containing scaffolds such as 3-azabicyclo[3.1.0]­hexanes are very important and frequently occurring motifs in biologically active compounds. We disclose a flexible two-step protocol for their efficient and selective access.
Nicolai Cramer (1516678), Dan Forster (11285170), Ouidad Lahtigui (10017538), Coralie Duchemin (6974873)   +3 more
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Synthesis of Dopamine Transporter Selective 3‐{2‐(Diarylmethoxyethylidene)}‐8‐alkylaryl‐8‐azabicyclo[3.2.1]octanes.

, 2003
A series of 3-{2-(diarylmethoxyethylidene)}-8-alkylaryl-8-azabicyclo[3.2.1]octanes was synthesized and the binding affinities of the compounds were determined at the dopamine and serotonin transporters.
Amy L. Bradley, Sari Izenwasser, Shaine Cararas, Cararas, Shaine, Mark L. Trudell, Dean Wade, Trudell, Mark L, Bradley, Amy L, Izenwasser, Sari, Wade, Dean   +9 more
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[2+2]-Photocycloaddition of N‑Benzylmaleimide to Alkenes As an Approach to Functional 3‑Azabicyclo[3.2.0]heptanes

, 2018
A one-step synthesis of functionalized 3-azabicyclo[3.2.0]­heptanes by [2+2]-photochemical intermolecular cycloaddition of N-benzylmaleimide to alkenes was elaborated. The obtained compounds were easily transformed into the bi- and tricyclic analogues of
Maryna V. Samoilenko (4951852), Yevhen A. Skalenko (4951849), Aleksandr V. Denisenko (2103151), Tetiana V. Druzhenko (4951843), Oleksandr P. Dacenko (4951846), Serhii A. Trofymchuk (4951855), Pavel K. Mykhailiuk (579411), Andrey A. Tolmachev (2055490), Oleksandr O. Grygorenko (1617082)   +8 more
core   +2 more sources

3-thia-7-azabicyclo(3.3.L)Nonanes and Derivatives as Antiarrhythmic Agents

, 1982
3-Thia-7-azabicyclo(3.3.1)nonanes and derivatives thereof are disclosed. The preparation of these compounds is given.

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Synthesis and antiaggregant and hypotensive activity of benzo-annelated azabicyclo[m.n.0]alkanes

, 2009
Three-component condensation of veratrole, isobutylene oxide, and aliphatic omega-chloronitriles via the Ritter reaction leads to 1-(omega-chloroalkyl)-6,7-dimethoxy-3,3-dimethyl-3,4-dihydroisoquinolines, the reduction of which with NaBH4 yields ...
Syropyatov, B., Shklyaev, Y., Glushkov, V., Dolzhenko, Anton, Stryapunina, O.   +4 more
core   +1 more source

Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes

, 2003
Synthesis of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes by cycloaddition and subsequent cross-coupling reaction is described. Binding affinity of these novel compounds towards the characteristic receptorial targets of ibogaine is illustrated.
Martinelli, Marisa, S. Efange, A. Giardini, Giardini, Alessandra, R. Favia, M. Martinelli, D. Mash, Silvani, Alessandra, Passarella, Daniele, Lesma, Giordano, D. Passarella, Efange, Simon M.N, Mash, Deborah C, A. Silvani, B. Danieli, G. Lesma, Danieli, Bruno, Favia, Raffaele   +17 more
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Synthesis and Biological Evaluation at Nicotinic Acetylcholine Receptors of N-Arylalkyl- and N-Aryl-7-Azabicyclo[2.2.1]heptanes

, 2016
A new series of N-arylalkyl-substituted 7-azabicyclo[2.2.1]heptanes and N-aryl-substituted 7-azabicyclo[2.2.1]heptanes were synthesized and evaluated as potential ligands for neuronal nicotinic acetylcholine receptors. The in vitro binding affinities (Ki)
Shaoyi Chen (2588569), Edwin D. Stevens (2323693), Chunming Zhang (297189), Dean Wade (2690428), Dennis Paul (3013080), Sari Izenwasser (2690431), Mark L. Trudell (2362717), Jie Cheng (294193)   +7 more
core   +1 more source