Results 21 to 30 of about 3,736 (153)

A Novel Class of “Super‐Strained” Spiro Heterocycles: Gateway to 1‐Azaspiro[3.3]heptane Derivatives, and Biological Validation

Angewandte Chemie, EarlyView.
A new class of “super‐strained” spiro heterocycles—spirocyclic 1‐azabicyclo[1.1.0]butanes—was synthesized via insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into substituted azirines. The stability of this new class of compounds was studied.
Philipp Natho, Annarita Vicenti, Marco Colella, Francesco Pasca, Giuseppe Romanazzi, Mauro Niso, Carmen Abate, Ernesto Mesto, Emanuela Schingaro, Renzo Luisi   +9 more
wiley   +2 more sources

Borylcyclopropanes: Synthetic Strategies and Applications

Angewandte Chemie, EarlyView.
Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley   +2 more sources

A convenient synthesis of CHF₂O-containing pyrrolidines and related compounds — Perspective building blocks for drug discovery

SynOpen
Fluorine-containing organic molecules, including CHF2O-derivatives, are among the most sought-after in medicinal chemistry. In the current work, a mini-library of 21 compounds with a CHF2O-motif incorporated with azetidine, pyrrolidine (proline ...
Kostiantyn Levchenko, Ivan Virstiuk, Daria Menshykova, Nazariy Pokhodylo   +3 more
doaj   +1 more source

Synthesis and characterization of Novel Schiff bases and evaluation of Corrosion inhibitors and biological activity

مجلة علوم ذي قار, 2019
Novel Schiff bases have been prepared from (6R,7R)-3-[( acetyloxy)methyl]-7-[[( Z)-2-(2aminothiazol-4-yl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]-oct-2-ene-2carboxylate sodium and 2,4-dihydroxy benzaldehyde ,3-methoxy-4-hydroxy
Ahmed M. Jassim
doaj   +4 more sources

2,4-Bis(2-methylphenyl)-3-azabicyclo[3.3.1]nonan-9-one O-methyloxime

Acta Crystallographica Section E, 2010
The molecule of the title compound, C23H28N2O, exists in a twin-chair conformation, with equatorial orientation of the ortho-tolyl groups on both sides of the secondary amino group. The title oxime compound and its ketone precursor 2,4-bis(2-methylphenyl)
P. Parthiban, V. Ramkumar, Yeon Tae Jeong   +2 more
doaj   +1 more source

Domino reactions of 2H-azirines with acylketenes from furan-2,3-diones: Competition between the formation of ortho-fused and bridged heterocyclic systems

Beilstein Journal of Organic Chemistry, 2014
3-Aryl-2H-azirines react with acylketenes, generated by thermolysis of 5-arylfuran-2,3-diones, to give bridged 5,7-dioxa-1-azabicyclo[4.4.1]undeca-3,8-diene-2,10-diones and/or ortho-fused 6,6a,12,12a-tetrahydrobis[1,3]oxazino[3,2-a:3′,2′-d]pyrazine-4,10 ...
Alexander F. Khlebnikov, Mikhail S. Novikov, Viktoriia V. Pakalnis, Roman O. Iakovenko, Dmitry S. Yufit   +4 more
doaj   +1 more source

Photogenerated Oxetanes as a Gateway to Uphill Cyclopropanation

Angewandte Chemie International Edition, EarlyView.
An atom‐economical route to densely functionalized cyclopropanes from furans and photochemically activated aldehydes is enabled by a unique oxetane‐to‐cyclopropane rearrangement. These cyclopropanes can be used to access complex bioactive scaffolds and serve as a platform for asymmetric cyclopropane synthesis.
Tim Köglmeier, Thomas J. Tiefel, Oliver Reiser   +2 more
wiley   +1 more source

A Mononuclear Ruthenium(V)‐Imido Complex With Hydrogen Bonding in the Second Coordination Sphere Forming Aziridines Without N‐Substituents From Alkenes in Water

Angewandte Chemie, Volume 138, Issue 29, 13 July 2026.
This study employs a RuV═NH complex with hydrogen‐bonding (HB) sites in the SCS to afford non‐N‐substituted aziridines selectively. Nitrogen‐atom transfer occurs from the RuV═NH complex to alkenes in water to produce aziridine derivatives in high yields.
Tomoya Ishizuka, Chisato Ogawa, Yoshihito Shiota, Shunsuke Nozawa, Hiroaki Kotani, Shin‐ichi Adachi, Kazunari Yoshizawa, Takahiko Kojima   +7 more
wiley   +2 more sources

Investigation of the role of stereoelectronic effects in the conformation of piperidones by NMR spectroscopy and X-ray diffraction

Beilstein Journal of Organic Chemistry, 2015
This paper reports the synthesis of a series of piperidones 1–8 by the Mannich reaction and analysis of their structures and conformations in solution by NMR and mass spectrometry.
Cesar Garcias-Morales, David Ortegón-Reyna, Armando Ariza-Castolo   +2 more
doaj   +1 more source

Phosphoryl Radicals from Trivalent Iminyl Phosphines: A Photocatalytic Approach to N‐Phosphoryl Azetidines

Angewandte Chemie, Volume 138, Issue 29, 13 July 2026.
Photochemically generated phosphoryl radicals from iminyl phosphines enable strain‐release addition to azabicyclobutanes, providing access to elusive N‐phosphoryl azetidines. Combined experimental, computational, and EPR studies reveal an unconventional water‐assisted photoredox pathway.
Chandu G. Krishnan, Gabriel Cormier, Stefano A. Serapian, Marco Bortolus, Luca Dell'Amico   +4 more
wiley   +2 more sources