Results 21 to 30 of about 1,579,156 (183)

Biological Evaluation and Theoretical Study of Bi-dentate Ligand for Amoxicillin Derivative with Some Metal Ions

مجلة بغداد للعلوم, 2021
In this paper, the complexes of Shiff base of Methyl -6-[2-(diphenylmethylene)amino)-2-(4-hydroxyphenyl)acetamido]-2,2-dimethyl-5-oxo-1-thia-4-azabicyclo[3.2.0]heptane-3-carboxylate (L) with Cobalt(II), Nickel(II), Cupper(II) and Zinc(II) have been ...
Sahar S. Hassan, Nidhal M. Hassan, Shaymaa Rajab Baqer, Asmaa M. saleh   +3 more
doaj   +1 more source

Study of Cytotoxicity of Spiro-Fused [3-Azabicyclo[3.1.0]hexane]oxindoles against Tumor Cell Lines

Medical Sciences Forum, 2022
Oncological diseases are one of the most common public health problems and the second leading cause of death after cardiovascular disease. Natural products or synthetic compounds derived from natural products continue to be excellent sources for new drug
Anton A. Kornev, Stanislav V. Shmakov, Alexey S. Klyuchnikov, Alexey V. Artemov, Alexander V. Stepakov, Vitali M. Boitsov   +5 more
doaj   +1 more source

Highly selective synthesis of functionalized morphan derivatives through a multi-component cascade reaction of 3-formylchromones, 2-naphthols, and enaminones

Green Synthesis and Catalysis, 2023
A novel protocol for the preparation of highly functionalized 2-azabicyclo[3.3.1]nonane (morphan) derivatives via a multicomponent cascade reaction, involving 3-formylchromones, 2-naphthols, and enaminones in the ionic liquid [BMIM]PF6 as the solvent and
Xinling Cao, Yinggang Duan, Kaihong Lv, Zihan Lu, Yihua Chen, Shengjiao Yan   +5 more
doaj   +1 more source

Pyridines from azabicyclo[3.2.0]hept-2-en-4-ones through a proposed azacyclopentadienone [PDF]

, 2012
Pyridines have been formed by heating azabicyclo[3.2.0]hept-2-en-4-ones in toluene. The generation of a 3-azacyclopentadienone intermediate via a [2+2]-cycloreversion is proposed as the key step.
Khan, Musharraf, Khan, Musharraf N., Vishnu V. R. Kondakal, M. Ilyas Qamar, Qamar, M. Ilyas, Hemming, Karl, Rice, Craig R., Karl Hemming, Craig R. Rice, Kondakal, Vishnu V.R., Qamar, Muhammad Ilyas, Arnaud Pitard, Pitard, Arnaud, Musharraf N. Khan, Kondakal, Vishnu   +14 more
core   +1 more source

Synthesis, Theoretical Study, and Biological Evaluation of Some Metal Ions with Ligand "Methyl -6-[2-(4-Hydroxyphenyl) -2-((1-Phenylethylidene) Amino) Acetamido] -2,2-Dimethyl-5—Oxo-1-Thia-4-Azabicyclo [3.2.0] Heptane-3-Carboxyylate

مجلة بغداد للعلوم, 2023
Schiff base (methyl 6-(2- (4-hydroxyphenyl) -2- (1-phenyl ethyl ideneamino) acetamido) -3, 3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylate)Co(II), Ni(II), Cu (II), Zn (II), and Hg(II)] ions were employed to make certain complexes ...
Sahar S. Hassan, Nafeesa J. Kadhim , Zahraa. A. Jaber   +2 more
doaj   +1 more source

Unexpected Resistance to Base-Catalyzed Hydrolysis of Nitrogen Pyramidal Amides Based on the 7-Azabicyclic[2.2.1]heptane Scaffold

Molecules, 2018
Non-planar amides are usually transitional structures, that are involved in amide bond rotation and inversion of the nitrogen atom, but some ground-minimum non-planar amides have been reported.
Diego Antonio Ocampo Gutiérrez de Velasco, Aoze Su, Luhan Zhai, Satowa Kinoshita, Yuko Otani, Tomohiko Ohwada   +5 more
doaj   +1 more source

Discovery of a Potent Highly Biased MOR Partial Agonist among Diastereomeric C9-Hydroxyalkyl-5-phenylmorphans

Molecules, 2023
All possible diastereomeric C9-hydroxymethyl-, hydroxyethyl-, and hydroxypropyl-substituted 5-phenylmorphans were synthesized to explore the three-dimensional space around the C9 substituent in our search for potent MOR partial agonists.
Joshua A. Lutz, Agnieszka Sulima, Eugene S. Gutman, Eric W. Bow, Dan Luo, Sophia Kaska, Thomas E. Prisinzano, Carol A. Paronis, Jack Bergman, Gregory H. Imler, Andrew T. Kerr, Arthur E. Jacobson, Kenner C. Rice   +12 more
doaj   +1 more source

Exploration of Novel Mono Hydroxamic Acid Derivatives as Inhibitors for Histone Deacetylase Like Protein (HDLP) by Molecular Dynamics Studies

Indonesian Journal of Chemistry, 2022
The acetylation modification process of histone has an essential role in the epigenetic regulation of gene expression. This process is controlled by the balance between histone deacetylases (HDAC) and histone acetyltransferases (HAT).
Gunasingham Parthiban, Ramachandren Dushanan, Samantha Weerasinghe, Dhammike Dissanayake, Rajendram Senthilnithy   +4 more
doaj   +1 more source

Synthesis of 2-(Pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(Pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(Pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a Class of Potent Nicotinic Acetylcholine Receptor–Ligands

, 2016
In an attempt to generate nicotinic acetylcholine receptor (nAChR) ligands selective for the α4β2 and α7 subtype receptors we designed and synthesized constrained versions of anabasine, a naturally occurring nAChR ligand.
Balwinder S. Bhatti (2025670), Craig H. Miller (2019703), Niranjan Deo (2440585), Scott R. Breining (2440588), Cynthia S. Day (1336956), William S. Caldwell (2405212), Peter A. Crooks (1474879), Jon-Paul Strachan (2025682), Persida Tahiri (2440591)   +8 more
core   +2 more sources

A de‐novo Approach Towards Divergent [3+2π/σ] Photocycloadditions of Nitrones via Assembly‐Controlled Kinetic Electron Transfer Gating

Angewandte Chemie, EarlyView.
A metal‐free photocatalytic platform converts nitrones into 4‐isoxazolines and oxa–aza–bicycloheptanes through divergent [3+2π/σ] cycloadditions. Assembly‐controlled kinetic electron transfer gating dictates substrate activation, enabling selective reactivity beyond thermodynamic expectations.
Nayan Saha, Rajesh Kancherla, Jorge Escorihuela, Shana Chandran, Mrinal K. Bera, Magnus Rueping, Burkhard König   +6 more
wiley   +2 more sources