Results 21 to 30 of about 7,278 (228)

Selective Synthesis of N-Acylnortropane Derivatives in Palladium-Catalysed Aminocarbonylation

Molecules, 2021
The aminocarbonylation of various alkenyl and (hetero)aryl iodides was carried out using tropane-based amines of biological importance, such as 8-azabicyclo[3.2.1]octan-3-one (nortropinone) and 3α-hydroxy-8-azabicyclo[3.2.1]octane (nortropine) as N ...
László Kollár, Ádám Erdélyi, Haroon Rasheed, Attila Takács   +3 more
doaj   +1 more source

Synthesis and Characterization of Two Schiff Base Tetradentate Ligands and their Related Complexes of [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2012
:The compound [H2L1] (2,6-di(phenyl-4-methyl) [3.3.1] azabicyclo-9-2-amino ethylimine) was used to prepare two novel Schiff base ligands 2,4-bis [2,6-di(phenyl-4-methyl)[3.3.1] azabicyclo-9- 2-imine ethylimine] butane [L2] and 2,5-bis [2,6-di(phenyl-4 ...
Mahmoud S. muter
doaj   +1 more source

Optimized synthesis of enantiomeric C9-keto-5-phenylmorphans, essential intermediates for novel MOR agonists and antagonists

Results in Chemistry, 2022
Two modifications of previous procedures enabled the high-yield scalable synthesis of the pharmacologically important enantiomers of a C9-keto-5-phenylmorphan ((1R,5R)- and (1S,5S)-5-(3-methoxyphenyl)-2-methyl-2-azabicyclo[3.3.1]nonan-9-one).
Agnieszka Sulima, Jason A. Deck, Muneaki Kurimura, Arthur E. Jacobson, Kenner C. Rice   +4 more
doaj   +1 more source

Antiprotozoal Activity of Azabicyclo-Nonanes Linked to Tetrazole or Sulfonamide Cores

Molecules, 2022
N-(Aminoalkyl)azabicyclo[3.2.2]nonanes possess antiplasmodial and antitrypanosomal activity. A series with terminal tetrazole or sulfonamido partial structure was prepared. The structures of all new compounds were confirmed by NMR and IR spectroscopy and
Johanna Dolensky, Clemens Hinteregger, Andreas Leitner, Werner Seebacher, Robert Saf, Ferdinand Belaj, Pascal Mäser, Marcel Kaiser, Robert Weis   +8 more
doaj   +1 more source

Efficient and regioselective synthesis of dihydroxy-substituted 2-aminocyclooctane-1-carboxylic acid and its bicyclic derivatives

Beilstein Journal of Organic Chemistry, 2022
The first synthesis of 2-amino-3,4-dihydroxycyclooctane-1-carboxylic acid, methyl 6-hydroxy-9-oxo-8-oxabicyclo[5.2.1]decan-10-yl)carbamate, and 10-amino-6-hydroxy-8-oxabicyclo[5.2.1]decan-9-one starting from cis-9-azabicyclo[6.2.0]dec-6-en-10-one is ...
İlknur Polat, Selçuk Eşsiz, Uğur Bozkaya, Emine Salamci   +3 more
doaj   +1 more source

Reaction of quinaldine with 4,6-di(tert-butyl)-3-nitro-1,2-benzoquinone. Dependence of the outcome on the reaction conditions and a deeper insight into the mechanism

Heliyon, 2023
Condensation of quinaldine with 4,6-di (tert-butyl)-3-nitro-1,2-benzoquinone results in the formation of 5,7-di (tert-butyl)-2-(quinoline-2-yl)-1,3-tropolone, 5,7-di (tert-butyl)-4-nitro-2-(quinoline-2-yl)-1,3-tropolone, 3,3-dimethyl-2-(5-hydroxy-4-nitro-
Tatyana A. Krasnikova, Yurii A. Sayapin, Inna O. Tupaeva, Eugeny A. Gusakov, Ilya V. Ozhogin, Anton V. Lisovin, Mikhail V. Nikogosov, Oleg P. Demidov, Duong Nghia Bang, Tran Dai Lam, Nguyen Thi Thu Trang, Alexander D. Dubonosov, Vladimir I. Minkin   +12 more
doaj   +1 more source

Biological Evaluation and Theoretical Study of Bi-dentate Ligand for Amoxicillin Derivative with Some Metal Ions

مجلة بغداد للعلوم, 2021
In this paper, the complexes of Shiff base of Methyl -6-[2-(diphenylmethylene)amino)-2-(4-hydroxyphenyl)acetamido]-2,2-dimethyl-5-oxo-1-thia-4-azabicyclo[3.2.0]heptane-3-carboxylate (L) with Cobalt(II), Nickel(II), Cupper(II) and Zinc(II) have been ...
Sahar S. Hassan, Nidhal M. Hassan, Shaymaa Rajab Baqer, Asmaa M. saleh   +3 more
doaj   +1 more source

Photochemical Deracemization of Chromanes and its Application to the Synthesis of Enantiopure Bioactive Compounds. [PDF]

Angew Chem Int Ed Engl
Various substituted chromane‐2‐carboxamides were successfully deracemized by employing a chiral benzophenone (BP, 10 mol%) as photocatalyst and an achiral thiol as additive (20 mol%). The method was applied to the concise enantioselective synthesis of five active pharmaceutical ingredients.
Ghosh B, Iglhaut M, Babushkina D, Pauls M, Bannwarth C, Bach T.   +5 more
europepmc   +2 more sources

Study of Cytotoxicity of Spiro-Fused [3-Azabicyclo[3.1.0]hexane]oxindoles against Tumor Cell Lines

Medical Sciences Forum, 2022
Oncological diseases are one of the most common public health problems and the second leading cause of death after cardiovascular disease. Natural products or synthetic compounds derived from natural products continue to be excellent sources for new drug
Anton A. Kornev, Stanislav V. Shmakov, Alexey S. Klyuchnikov, Alexey V. Artemov, Alexander V. Stepakov, Vitali M. Boitsov   +5 more
doaj   +1 more source

Highly selective synthesis of functionalized morphan derivatives through a multi-component cascade reaction of 3-formylchromones, 2-naphthols, and enaminones

Green Synthesis and Catalysis, 2023
A novel protocol for the preparation of highly functionalized 2-azabicyclo[3.3.1]nonane (morphan) derivatives via a multicomponent cascade reaction, involving 3-formylchromones, 2-naphthols, and enaminones in the ionic liquid [BMIM]PF6 as the solvent and
Xinling Cao, Yinggang Duan, Kaihong Lv, Zihan Lu, Yihua Chen, Shengjiao Yan   +5 more
doaj   +1 more source