Results 21 to 30 of about 4,192 (189)

Synthesis, Theoretical Study, and Biological Evaluation of Some Metal Ions with Ligand "Methyl -6-[2-(4-Hydroxyphenyl) -2-((1-Phenylethylidene) Amino) Acetamido] -2,2-Dimethyl-5—Oxo-1-Thia-4-Azabicyclo [3.2.0] Heptane-3-Carboxyylate

مجلة بغداد للعلوم, 2023
Schiff base (methyl 6-(2- (4-hydroxyphenyl) -2- (1-phenyl ethyl ideneamino) acetamido) -3, 3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylate)Co(II), Ni(II), Cu (II), Zn (II), and Hg(II)] ions were employed to make certain complexes ...
Sahar S. Hassan, Nafeesa J. Kadhim , Zahraa. A. Jaber   +2 more
doaj   +1 more source

Unexpected Resistance to Base-Catalyzed Hydrolysis of Nitrogen Pyramidal Amides Based on the 7-Azabicyclic[2.2.1]heptane Scaffold

Molecules, 2018
Non-planar amides are usually transitional structures, that are involved in amide bond rotation and inversion of the nitrogen atom, but some ground-minimum non-planar amides have been reported.
Diego Antonio Ocampo Gutiérrez de Velasco, Aoze Su, Luhan Zhai, Satowa Kinoshita, Yuko Otani, Tomohiko Ohwada   +5 more
doaj   +1 more source

Strain‐Release‐Driven Friedel‐Crafts Spirocyclization of Azabicyclo[1.1.0]butanes [PDF]

, 2022
The identification of spiro N-heterocycles as scaffolds that display structural novelty, three-dimensionality, beneficial physicochemical properties, and enable the controlled spatial disposition of substituents has led to a surge of interest in ...
Aggarwal, Varinder K., Aggarwal, Varinder Kumar, Jasper L. Tyler, Noble, Adam, Adam Noble, Varinder K. Aggarwal, Tyler, Jasper L.   +6 more
core   +1 more source

Synthesis of 2-(Pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(Pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(Pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a Class of Potent Nicotinic Acetylcholine Receptor–Ligands

, 2016
In an attempt to generate nicotinic acetylcholine receptor (nAChR) ligands selective for the α4β2 and α7 subtype receptors we designed and synthesized constrained versions of anabasine, a naturally occurring nAChR ligand.
Balwinder S. Bhatti (2025670), Craig H. Miller (2019703), Niranjan Deo (2440585), Scott R. Breining (2440588), Cynthia S. Day (1336956), William S. Caldwell (2405212), Peter A. Crooks (1474879), Jon-Paul Strachan (2025682), Persida Tahiri (2440591)   +8 more
core   +2 more sources

Discovery of a Potent Highly Biased MOR Partial Agonist among Diastereomeric C9-Hydroxyalkyl-5-phenylmorphans

Molecules, 2023
All possible diastereomeric C9-hydroxymethyl-, hydroxyethyl-, and hydroxypropyl-substituted 5-phenylmorphans were synthesized to explore the three-dimensional space around the C9 substituent in our search for potent MOR partial agonists.
Joshua A. Lutz, Agnieszka Sulima, Eugene S. Gutman, Eric W. Bow, Dan Luo, Sophia Kaska, Thomas E. Prisinzano, Carol A. Paronis, Jack Bergman, Gregory H. Imler, Andrew T. Kerr, Arthur E. Jacobson, Kenner C. Rice   +12 more
doaj   +1 more source

Exploration of Novel Mono Hydroxamic Acid Derivatives as Inhibitors for Histone Deacetylase Like Protein (HDLP) by Molecular Dynamics Studies

Indonesian Journal of Chemistry, 2022
The acetylation modification process of histone has an essential role in the epigenetic regulation of gene expression. This process is controlled by the balance between histone deacetylases (HDAC) and histone acetyltransferases (HAT).
Gunasingham Parthiban, Ramachandren Dushanan, Samantha Weerasinghe, Dhammike Dissanayake, Rajendram Senthilnithy   +4 more
doaj   +1 more source

Phosphoryl Radicals from Trivalent Iminyl Phosphines: A Photocatalytic Approach to N‐Phosphoryl Azetidines

Angewandte Chemie, EarlyView.
Photochemically generated phosphoryl radicals from iminyl phosphines enable strain‐release addition to azabicyclobutanes, providing access to elusive N‐phosphoryl azetidines. Combined experimental, computational, and EPR studies reveal an unconventional water‐assisted photoredox pathway.
Chandu G. Krishnan, Gabriel Cormier, Stefano A. Serapian, Marco Bortolus, Luca Dell'Amico   +4 more
wiley   +2 more sources

Studies on 1-Azabicyclo Compounds. XVI. Synthesis of 1'-Methylindan-2-spiro-2'-piperazine and Related Compounds

Chemical and Pharmaceutical Bulletin, 1973
A new synthesis of the spirodiamines (IIIa-c) from the methiodides (Ia-c) via the spiroaminolactams (VIIa-c) by Stevens rearrangement is described.
KATO, HIDEO, KOSHINAKA, EIICHI, ARATA, YOSHIO, HANAOKA, MIYOJI   +3 more
openaire   +2 more sources

Pd^II‐Mediated Oxidative Amination for Access to a 9‐Azabicyclo[4.2.1]nonane Compound Library and Anatoxin‐a [PDF]

European Journal of Organic Chemistry, 2018
Intramolecular oxidative amination of readily accessible aminocyclooct‐4‐enes provides rapid and regioselective access to the 9‐azabicyclo[4.2.1]nonane framework characteristic of the natural product anatoxin‐a (1). This has enabled the synthesis of sp3‐rich chemical scaffolds suitable for diversification.
Dawood, Rafid S.; Chidipudi, Suresh R.; O'Connor, Daniel C.; Lewis, William; Hamza, Daniel; Pearce, Christopher A.; Jones, Geraint; Wilkie, Ross P.; Georgiou, Irene; Storr, Thomas E.; Moore, Jonathan C.; Stockman, Robert A.   +12 more
openaire   +1 more source

Pyridines from azabicyclo[3.2.0]hept-2-en-4-ones through a proposed azacyclopentadienone

, 2012
Pyridines have been formed by heating azabicyclo[3.2.0]hept-2-en-4-ones in toluene. The generation of a 3-azacyclopentadienone intermediate via a [2+2]-cycloreversion is proposed as the key step.
Khan, Musharraf, Khan, Musharraf N., Vishnu V. R. Kondakal, M. Ilyas Qamar, Qamar, M. Ilyas, Hemming, Karl, Rice, Craig R., Karl Hemming, Craig R. Rice, Kondakal, Vishnu V.R., Qamar, Muhammad Ilyas, Arnaud Pitard, Pitard, Arnaud, Musharraf N. Khan, Kondakal, Vishnu   +14 more
core   +1 more source