Results 21 to 30 of about 5,421 (159)

Pharmacokinetic and pharmacodynamic evaluation of sulbactam-durlobactam in a critically ill patient on continuous venovenous hemofiltration infected with carbapenem-resistant Acinetobacter baumannii-calcoaceticus complex. [PDF]

Pharmacotherapy
Background: Drug databases currently do not provide dosing guidance for sulbactam-durlobactam in continuous renal replacement therapy. Herein, we present the first in vivo pharmacokinetic (PK) evaluation of sulbactam-durlobactam during continuous ...
Kufel WD, Zeineddine N, Fouad A, Roenfanz HF, Shields RK, Kline EG, Warner J, Hanrahan K, Kuti JL.   +8 more
europepmc   +4 more sources

Consistent in vitro activity of sulbactam-durlobactam against genetically diverse carbapenem-resistant Acinetobacter baumannii in a high-endemic Brazilian setting [PDF]

Antimicrobial Agents and Chemotherapy
Carbapenem-resistant Acinetobacter baumannii (CRAb) causes high-mortality infections, with limited treatment options. We evaluated sulbactam-durlobactam activity against 94 isolates from Brazil.
Gabriela da Silva Collar, Luana Silva Dornelles, Júlia Cover Salvador, Jaqueline Becker Pinto, Dariane Castro Pereira, Patrícia Orlandi Barth, João Vitor Barboza Cardoso, William Latosinski Matos, Mariana Preussler Mott, Afonso Luís Barth, Andreza Francisco Martins, Juliana Caierão   +11 more
doaj   +2 more sources

Sulbactam–durlobactam and cefiderocol combination treatment of Burkholderia cenocepacia-associated Fitz–Hugh–Curtis syndrome [PDF]

Antimicrobial Agents and Chemotherapy
A 50-year-old woman with cystic fibrosis (CF) and lung transplantation developed persistent deep abscesses due to multidrug-resistant (MDR) Burkholderia cenocepacia, unresponsive to multiple antibiotics and surgeries.
Bhavita Gaglani, Tessa M. Andermann, Claire Wate, Jorge Oldan, Chirag S. Desai, Steven H. Marshall, Robert A. Bonomo, Ray Coakley, David van Duin, Anne Lachiewicz   +9 more
doaj   +2 more sources

Pharmacokinetics of sulbactam-durlobactam in patients with <i>Acinetobacter baumannii</i> ventriculitis: a report of two cases. [PDF]

Antimicrob Agents Chemother
ABSTRACT Two adult patients with ventriculitis due to Acinetobacter baumannii were treated with intravenous sulbactam-durlobactam as a part of a combination regimen. Penetration into the central nervous system was estimated (by
Pouya N, Finch NA, Granillo A, Bhimraj A, Tam VH, Miller WR.   +5 more
europepmc   +4 more sources

In vitro efficacy of sulbactam/durlobactam combined with β-lactam antibiotics in Australian Mycobacterium abscessus isolates. [PDF]

J Antimicrob Chemother
Abstract Background and objectives Mycobacterium abscessus has extensive innate and acquired antibiotic resistance resulting in limited antibiotic treatment options and poor clinical outcomes. Currently, the only β-lactam antibiotics with efficacy against M. abscessus are imipenem and cefoxitin.
Patterson-Fahy K, Carter R, Bell SC, Evans IES, Burke AJ, Thomson RM.   +5 more
europepmc   +6 more sources

A Clinical Case of Treatment-Emergent Acinetobacter baumannii Non-Susceptibility to Sulbactam-Durlobactam. [PDF]

Clin Infect Dis
Abstract We report an eightfold increase in sulbactam-durlobactam MICs in a carbapenem-resistant Acinetobacter baumannii cerebrospinal fluid isolate recovered after 14 days of sulbactam-durlobactam plus meropenem therapy. Treatment-emergent mutations in the AdeFGH efflux system were identified, accompanied by a 166-fold increase in ...
Sharara SL, Diaz L, Asempa TE, Martinez JRW, Canales N, Bergman Y, Murphy SG, Karaba SM, Clark AE, Zurawski DV, Cosgrove SE, Simner PJ, Munita JM, Tamma PD.   +13 more
europepmc   +2 more sources

An overview of sulbactam‐durlobactam approval and implications in advancing therapeutics for hospital‐acquired and ventilator‐associated pneumonia by acinetobacter baumannii‐calcoaceticus complex: A narrative review

Health Science Reports
Purpose Infections caused by Acinetobacter baumannii, particularly those resistant to antibiotics such as carbapenem, have become a global health crisis with a significant mortality rate.
Ayush Anand, Amogh Verma, Sarabjeet Kaur, Priyangi Kathayat, Rachel M. Manoj, Aakanksha Aakanksha, Justice K. Turzin, Prakasini Satapathy, Mahalaqua N. Khatib, Shilpa Gaidhane, Quazi S. Zahiruddin, Neelima Kukreti, Sarvesh Rustagi, Arihant Surana   +13 more
doaj   +2 more sources

Susceptibility toward cefiderocol and sulbactam-durlobactam in extensively drug-resistant Acinetobacter baumannii detected from ICU admission screening in Hanoi, Vietnam, 2023 [PDF]

Microbiology Spectrum
Infections due to carbapenem-resistant Acinetobacter baumannii (CRAB) pose significant clinical challenges due to limited treatment options. In this study, we investigated the molecular epidemiology, resistance profiles, and genomic characteristics of ...
Sébastien Boutin, Nguyen Quang Toan, Thi Anh Mai Pham, Truong Nhat My, Nguyen Thi Kim Phuong, Bui Tien Sy, Nguyen Van Trong, Lisa Göpel, Leo Huber, Kaan Kocer, Le Thi Kieu Linh, Tran Thanh Tung, Nguyen Trong The, Le Huu Song, Thirumalaisamy P. Velavan, Dennis Nurjadi   +15 more
doaj   +2 more sources

Evaluation of sulbactam/durlobactam activity and synergy against highly drug-resistant <i>Acinetobacter baumannii</i> strains. [PDF]

JAC Antimicrob Resist
Abstract Background Acinetobacter baumannii is a bacterial pathogen frequently implicated in healthcare-associated infections, with limited effective treatment options due to widespread antibiotic resistance.
Halim J, Bouzo J, Carabetta VJ.
europepmc   +3 more sources

In Vitro Activity of Sulbactam–Durlobactam against Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates: A Multicentre Report from Italy [PDF]

Antibiotics, 2022
In the present study, the in vitro activity of the sulbactam–durlobactam (SUL–DUR) combination was evaluated against 141 carbapenem-resistant A. baumannii (CRAb) clinical strains collected from six Italian laboratories.
Bernardetta Segatore, Alessandra Piccirilli, Sabrina Cherubini, Luigi Principe, Giovanni Alloggia, Maria Lina Mezzatesta, Mario Salmeri, Stefano Di Bella, Roberta Migliavacca, Aurora Piazza, Elisa Meroni, Paolo Fazii, Daniela Visaggio, Paolo Visca, Venere Cortazzo, Giulia De Angelis, Arianna Pompilio, Mariagrazia Perilli   +17 more
doaj   +3 more sources