Results 171 to 180 of about 10,197 (217)

Pregnant women as a sentinel population for genomic surveillance of malaria in the Democratic Republic of the Congo: a population-based study.

open access: yesLancet Glob Health
Onyamboko M   +18 more
europepmc   +1 more source

COMBINATION OF MEFLOQUINE WITH SULFADOXINE-PYRIMETHAMINE COMPARED WITH TWO SULFADOXINE-PYRIMETHAMINE COMBINATIONS IN MALARIA CHEMOPROPHYLAXIS

The Lancet, 1985
Abstract 373 subjects occupationally exposed to high levels of malaria transmission were randomised into three groups. Group 1 received one tablet of sulfadoxine-pyrimethamine (SP) (each containing sulfadoxine 500 mg and pyrimethamine 25 mg) twice a week; group 2 received two tablets of sulfadoxine-pyrimethamine (SP) once a week; and group 3 received ...
Tin Thein Lwin   +3 more
openaire   +3 more sources

Mechanisms of sulfadoxine resistance in Plasmodium falciparum

Molecular and Biochemical Parasitology, 1986
Three possible mechanisms of resistance to sulfadoxine were investigated in resistant Plasmodium falciparum: drug uptake, metabolism and alternate pathways. Uptake of [35S] sulfadoxine was markedly reduced in resistant plasmodia. By Thin Layer Radiochromatography it could be demonstrated that plasmodia do not metabolize sulfadoxine to pharmacologically
Angela Dieckmann, Albrecht Jung
openaire   +3 more sources

EFFICACY OF CHLOROQUINE, AMODIAQUINE, SULFADOXINE-PYRIMETHAMINE, CHLOROQUINE-SULFADOXINE-PYRIMETHAMINE COMBINATION, AND AMODIAQUINE-SULFADOXINE-PYRIMETHAMINE COMBINATION IN CENTRAL AFRICAN CHILDREN WITH NONCOMPLICATED MALARIA

The American Journal of Tropical Medicine and Hygiene, 2005
This paper reports a two-phase study in Bangui, Central African Republic (CAR): first, we assessed the clinical efficacy to chloroquine (CQ), sulfadoxine-pyrimethamine (SP), and amodiaquine (AQ), then we tested the efficacy of two combinations: CQ + SP and AQ + SP.
Antoine Talarmin   +5 more
openaire   +3 more sources

Sulfadoxine–Pyrimethamine Combination in Congenital Toxoplasmosis

Pediatric Infectious Disease Journal, 2017
International ...
Chemla, Cathy, Villena, Isabelle
openaire   +3 more sources

Pyrimethamine–sulfadoxine resistance in Plasmodium falciparum: what next?

Trends in Parasitology, 2001
Chemotherapy remains the only practicable tool to control falciparum malaria in sub-Saharan Africa, where >90% of the world's burden of malaria mortality and morbidity occurs. Resistance is rapidly eroding the efficacy of chloroquine, and the combination pyrimethamine-sulfadoxine is the most commonly chosen alternative.
Sibley, Carol Hopkins   +9 more
openaire   +3 more sources

Pharmacokinetic Disposition of Sulfadoxine in Children with Acute Uncomplicated Falciparum Malaria Treated with Sulfadoxine–Pyrimethamine in South West Nigeria

American Journal of Therapeutics, 2012
Sulfadoxine (SDX)-pyrimethamine is currently recommended as a partner drug with artesunate in the chemotherapy of malaria. However, information on pharmacokinetic disposition of SDX-pyrimethamine in children is limited. Efforts in this study were thus devoted to evaluation of pharmacokinetic disposition of SDX using high-pressure liquid chromatographic
Abayomi O. Sijuade   +4 more
openaire   +3 more sources

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