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The Lancet, 1985
Abstract 373 subjects occupationally exposed to high levels of malaria transmission were randomised into three groups. Group 1 received one tablet of sulfadoxine-pyrimethamine (SP) (each containing sulfadoxine 500 mg and pyrimethamine 25 mg) twice a week; group 2 received two tablets of sulfadoxine-pyrimethamine (SP) once a week; and group 3 received ...
Tin Thein Lwin +3 more
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Abstract 373 subjects occupationally exposed to high levels of malaria transmission were randomised into three groups. Group 1 received one tablet of sulfadoxine-pyrimethamine (SP) (each containing sulfadoxine 500 mg and pyrimethamine 25 mg) twice a week; group 2 received two tablets of sulfadoxine-pyrimethamine (SP) once a week; and group 3 received ...
Tin Thein Lwin +3 more
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Mechanisms of sulfadoxine resistance in Plasmodium falciparum
Molecular and Biochemical Parasitology, 1986Three possible mechanisms of resistance to sulfadoxine were investigated in resistant Plasmodium falciparum: drug uptake, metabolism and alternate pathways. Uptake of [35S] sulfadoxine was markedly reduced in resistant plasmodia. By Thin Layer Radiochromatography it could be demonstrated that plasmodia do not metabolize sulfadoxine to pharmacologically
Angela Dieckmann, Albrecht Jung
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The American Journal of Tropical Medicine and Hygiene, 2005
This paper reports a two-phase study in Bangui, Central African Republic (CAR): first, we assessed the clinical efficacy to chloroquine (CQ), sulfadoxine-pyrimethamine (SP), and amodiaquine (AQ), then we tested the efficacy of two combinations: CQ + SP and AQ + SP.
Antoine Talarmin +5 more
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This paper reports a two-phase study in Bangui, Central African Republic (CAR): first, we assessed the clinical efficacy to chloroquine (CQ), sulfadoxine-pyrimethamine (SP), and amodiaquine (AQ), then we tested the efficacy of two combinations: CQ + SP and AQ + SP.
Antoine Talarmin +5 more
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Sulfadoxine–Pyrimethamine Combination in Congenital Toxoplasmosis
Pediatric Infectious Disease Journal, 2017International ...
Chemla, Cathy, Villena, Isabelle
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Pyrimethamine–sulfadoxine resistance in Plasmodium falciparum: what next?
Trends in Parasitology, 2001Chemotherapy remains the only practicable tool to control falciparum malaria in sub-Saharan Africa, where >90% of the world's burden of malaria mortality and morbidity occurs. Resistance is rapidly eroding the efficacy of chloroquine, and the combination pyrimethamine-sulfadoxine is the most commonly chosen alternative.
Sibley, Carol Hopkins +9 more
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American Journal of Therapeutics, 2012
Sulfadoxine (SDX)-pyrimethamine is currently recommended as a partner drug with artesunate in the chemotherapy of malaria. However, information on pharmacokinetic disposition of SDX-pyrimethamine in children is limited. Efforts in this study were thus devoted to evaluation of pharmacokinetic disposition of SDX using high-pressure liquid chromatographic
Abayomi O. Sijuade +4 more
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Sulfadoxine (SDX)-pyrimethamine is currently recommended as a partner drug with artesunate in the chemotherapy of malaria. However, information on pharmacokinetic disposition of SDX-pyrimethamine in children is limited. Efforts in this study were thus devoted to evaluation of pharmacokinetic disposition of SDX using high-pressure liquid chromatographic
Abayomi O. Sijuade +4 more
openaire +3 more sources

