Results 71 to 80 of about 414,769 (257)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

In vitro inhibition of Plasmodium falciparum rosette formation by Curdlan sulfate

, 2007
Spontaneous binding of infected erythrocytes to uninfected erythrocytes to form rosettes is a property of some strains of Plasmodium falciparum that is linked to severe complications of malaria.
Steen, Katie E, Bull, PC, Warimwe, G, Arman, M, Raza, Ahmed, Bull, Peter, Havlik, I, Steen, KE, Arman, Monica, Rowe, J Alexandra; id_orcid, Kyriacou, HM, Warimwe, George, Havlik, Ivan, Kyriacou, Helen M, Bull, Peter C, Raza, A, Rowe, JA   +16 more
core   +1 more source

Sulfate-Promoted Higher Alcohol Synthesis from CO₂ Hydrogenation

, 2022
Sulfur is usually regarded as a catalyst poison for many industrial reactions. Since an increasing number of studies have also reported that sulfate can serve as a promoter for certain reactions, the effects of sulfate on catalysts should be critically ...
Xinxin Zhang (309944), Xinlin Hong (2462854), Yanqiu Wang (646087), Guoliang Liu (1454761)   +3 more
core   +1 more source

Microbial sulfur transformations in sediments from Subglacial Lake Whillans

Frontiers in Microbiology, 2014
Diverse microbial assemblages inhabit subglacial aquatic environments. While few of these environments have been sampled, data reveal that subglacial organisms gain energy for growth from reduced minerals containing nitrogen, iron, and sulfur.
Alicia M Purcell, Jill A Mikucki, Amanda eAchberger, Irina eAlekhina, Carlo eBarbante, Brent Craig Christner, Dhritiman eGhosh, Alexander B Michaud, Andrew C Mitchell, John C Priscu, Reed eScherer, Mark eSkidmore, Trista J Vick-Majors, The WISSARD eScience Team   +13 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Benthic Dinitrogen Fixation Traversing the Oxygen Minimum Zone Off Mauritania (NW Africa)

Frontiers in Marine Science, 2017
Despite its potential to provide new nitrogen (N) to the environment, knowledge on benthic dinitrogen (N2) fixation remains relatively sparse, and its contribution to the marine N budget is regarded as minor.
Jessica Gier, Carolin R. Löscher, Andrew W. Dale, Stefan Sommer, Ulrike Lomnitz, Tina Treude, Tina Treude   +6 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Bioaugmentation of UASB reactors with immobilized Sulfurospirillum barnesii for simultaneous selenate and nitrate removal

, 2009
Whole-cell immobilization of selenate-respiring Sulfurospirillum barnesii in polyacrylamide gels was investigated to allow the treatment of selenate contaminated (790¿µg Se¿×¿L-1) synthetic wastewater with a high molar excess of nitrate (1,500 times) and
Lenz, M., O’Flaherty, V., Aelst, A.C., van, Enright, A.M., Lens, P.N.L.   +4 more
core   +1 more source

Unintended Laboratory-Driven Evolution Reveals Genetic Requirements for Biofilm Formation by Desulfovibrio vulgaris Hildenborough

mBio, 2017
Biofilms of sulfate-reducing bacteria (SRB) are of particular interest as members of this group are culprits in corrosion of industrial metal and concrete pipelines as well as being key players in subsurface metal cycling.
Kara B. De León, Grant M. Zane, Valentine V. Trotter, Gregory P. Krantz, Adam P. Arkin, Gareth P. Butland, Peter J. Walian, Matthew W. Fields, Judy D. Wall   +8 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source