Results 51 to 60 of about 30,605 (254)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Analysis of vitamin E metabolites including carboxychromanols and sulfated derivatives using LC/MS/MS

Journal of Lipid Research, 2015
Tocopherols and tocotrienols are metabolized via hydroxylation and oxidation of their hydrophobic side chain to generate 13′-hydroxychromanols (13′-OHs) and various carboxychromanols, which can be further metabolized by conjugation including sulfation ...
Qing Jiang, Tianlin Xu, Jianjie Huang, Amber S. Jannasch, Bruce Cooper, Chao Yang   +5 more
doaj   +1 more source

Sulfation of the extracellular polysaccharide from the edible fungus Stropharia rugosoannulata with its antioxidant activity

Journal of Future Foods, 2023
: An acidic extracellular polysaccharide (EPS) was gained from Stropharia rugosoannulata fermentation broth by the alcohol precipitate method. Sulfated derivative of EPS (S-EPS) was gained by chlorosulfonic acid-pyridine method and the conditions were as
Hui Hao, Chun Cui, Yuqing Xing, Xuewei Jia, Bingjie Ma, Wenyi Kang, Tianxiao Li, Mingqi Gao, Chunping Xu   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Steroid sulfation in adrenal tumors [PDF]

, 2021
ContextThe adrenal cortex produces specific steroid hormones including steroid sulfates such as dehydroepiandrosterone sulfate (DHEAS), the most abundant steroid hormone in the human circulation.
Lightning, Thomas Alec, Kroiss, Matthias, Mueller, Jonathan Wolf, Ronchi, Cristina L, Foster, Paul, Foster, Paul A, Weigand, Isabel, Mueller, Jonathan Wolf; id_orcid, Vogg, Nora, Ronchi, Cristina; id_orcid   +9 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Approaches to the Sulfation of Small Molecules:Current Progress and Future Directions [PDF]

Sulfation is one of the most important modifications that occur to a wide range of bioactive small molecules including polysaccharides, proteins, flavonoids, and steroids.
Alshehri, Jaber, Jones, Alan; id_orcid, Jaber, Alshehri, Alan, Jones   +3 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Original sulfation levels and sulfation changes of HS/heparin oligosaccharides after HSulf2 digestion.

, 2014
The sulfation level is repsented as the aveage number of sulfates per disaccharide. Deceased percentage shows the sulfation level decrease in percentage after HSulf2 digestion.
Matthew A. Nugent (333482), Jo Ann Buczek-Thomas (366939), Yu Huang (15093), Yang Mao (19788), Joseph Zaia (131775)   +4 more
core   +1 more source

Tyrosine Sulfation of Statherin

International Journal of Biological Sciences, 2007
Tyrosylprotein sulfotransferase (TPST), responsible for the sulfation of a variety of secretory and membrane proteins, has been identified and characterized in submandibular salivary glands (William et al. Arch Biochem Biophys 1997; 338: 90-96).
C. Kasinathan, N. Gandhi, P. Ramaprasad, P. Sundaram, N. Ramasubbu
doaj