Results 61 to 70 of about 1,048 (218)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Scientific ReportsThe chemokine receptor CCR5 is known to exist in cell surface subpopulations that differ in their capacity to engage ligands. One proposed explanation for this phenomenon is the presence of CCR5 species with different levels of post-translational ...
Inês Pinheiro +3 more
doaj +1 more source
Metabolism of deoxycholic acid in bile fistula patients
Journal of Lipid Research, 1971 Although it has been assumed that the secondary bile acid deoxycholic acid is not rehydroxylated by the human liver, little direct evidence is available to support this assumption.
RUSSELL F. HANSON, GALE WILLIAMS
doaj +1 more source
BMC Molecular and Cell Biology, 2022 Background Considering the high correlation between the functional decline in Alzheimer’s disease (AD) and the propagation of aggregated tau protein, many research efforts are focused on determining the underlying molecular mechanisms of tau spreading ...
Andreia Ferreira +7 more
doaj +1 more source
Liberation of sulfate from sulfate esters by soils [PDF]
Applied and Environmental Microbiology, 1976 When incubated with acid, alkaline, and neutral soils, a variety of synthetic sulfate esters representing the various classes of these compounds was hydrolyzed by enzymes, probably of microbial origin. The appearance of sulfate in the soil water occurred immediately after introduction into the soils with some esters, whereas with others it occurred ...
C, Houghton, R A, Rose
openaire +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Complement factor H, vitronectin, and opticin are tyrosine-sulfated proteins of the retinal pigment epithelium. [PDF]
PLoS ONE, 2014 Lack of tyrosine sulfation of ocular proteins results in disorganized photoreceptor structure and drastically reduced visual function, demonstrating the importance of this post-translational modification to vision.
Yogita Kanan +3 more
doaj +1 more source
A SULFATE CONUNDRUM: DISSOLVED SULFATES OF DEEP-SALINE BRINES AND CARBONATE ASSOCIATED SULFATES [PDF]
Geological Society of America Abstracts with Programs, 2016 Abstract Sulfates in deeply circulating brines and carbonate-associated sulfates (CAS) within sedimentary units of the Cambrian strata in the Illinois Basin record a complex history. Dissolved sulfate within the Mt. Simon Sandstone brines exhibits average δ34 S SO 4 values of 35.4‰ and δ18 O SO 4 values of 14.
Dana M. Labotka +2 more
openaire +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecules, 2012 EPS-1 was an exopolysaccharide produced by the medicinal fungus Cordyceps sinensis (Cs-HK1). In the present study, EPS-1 was sulfated with chlorosulfonic acid (CSA)-pyridine (Pyr) at different volume ratios, yielding four sulfated derivatives, SEPS-1A, B,
Jing-Kun Yan +3 more
doaj +1 more source