Results 1 to 10 of about 7,003 (228)

Engineering Chondroitinase‐Free Baculovirus‐Insect Cell Expression System for Efficient Synthesis of Chondroitin Sulphates [PDF]

Microbial Biotechnology
Owing to the high expression levels, proper protein folding and post‐translational modifications, baculovirus‐insect cell expression system is an ideal platform for producing active chondroitin sulfotransferases, which specifically catalyse the synthesis
Junyue Li, Yuqing Tian, Lihe She, Zhangliang Liu, Yingying Zhou, Yanyan Wang, Jihui Zhang, Leilei Zhu, Huarong Tan, Jine Li   +9 more
doaj   +2 more sources

Sulfotransferases and Sulfatases in Mycobacteria [PDF]

Chemistry & Biology, 2002
Analysis of the genomes of M. tuberculosis, M. leprae, M. smegmatis, and M. avium has revealed a large family of genes homologous to known sulfotransferases. Despite reports detailing a suite of sulfated glycolipids in many mycobacteria, a corresponding family of sulfotransferase genes remains uncharacterized.
Mougous, Joseph D, Green, Richard E, Williams, Spencer J, Brenner, Steven E, Bertozzi, Carolyn R   +4 more
openaire   +4 more sources

Identification and evolution of the plant sulfotransferase family [PDF]

BMC Genomics
Sulfotransferases (SOTs, EC 2.8.2.-), which catalyze sulfate conjugation reactions, are widespread across prokaryotes and eukaryotes. However, the origin, classification and evolution history of SOTs in plants are not as well understood as those in ...
Shuangxin Han, Zhujun Chen, Quanlong Liu, Yueying Ding, Jia Wang, Hongbo Liu, Junyang Zou, Zhiying Hong, Hongmei Zhang, Wenping Yang, Lan Zhang, Hongwei Liu, Min Yuan   +12 more
doaj   +2 more sources

Chemically guided single-cell transcriptomics reveals sulfotransferase-mediated scaffold remodeling in securinine biosynthesis [PDF]

Nature Communications
Securinega alkaloids possess a distinctive tetracyclic scaffold and are pharmaceutically relevant, yet their biosynthesis in Flueggea suffruticosa remains unresolved.
Sungjun Choung, Gyumin Kang, Taein Kim, Seoyoung Kim, Hyejung Yun, Yeojin Hwang, Hyeonjin Kim, Hangah Lim, Kwanyoung Moon, Sunkyu Han, Sang-Gyu Kim   +10 more
doaj   +2 more sources

The important roles of steroid sulfatase and sulfotransferases in gynecological diseases [PDF]

Frontiers in Pharmacology, 2016
Gynecological diseases such as endometriosis, adenomyosis and uterine fibroids, and gynecological cancers including endometrial cancer and ovarian cancer, affect a large proportion of women.
Tea eLanisnik Rizner
doaj   +2 more sources

Identification and Characterization of Two Aryl Sulfotransferases from Deep-Sea Marine Fungi and Their Implications in the Sulfation of Secondary Metabolites [PDF]

Marine Drugs
Sulfation plays a critical role in the biosynthesis of small molecules, regulatory mechanisms such as hormone signaling, and detoxification processes (phase II enzymes).
Nicolas Graziano, Beatriz Arce-López, Tristan Barbeyron, Ludovic Delage, Elise Gerometta, Catherine Roullier, Gaëtan Burgaud, Elisabeth Poirier, Laure Martinelli, Jean-Luc Jany, Nolwenn Hymery, Laurence Meslet-Cladiere   +11 more
doaj   +2 more sources

Structure and Function of Sulfotransferases [PDF]

Archives of Biochemistry and Biophysics, 2001
Sulfotransferases (STs) catalyze the transfer reaction of the sulfate group from the ubiquitous donor 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to an acceptor group of numerous substrates. This reaction, often referred to as sulfuryl transfer, sulfation, or sulfonation, is widely observed from bacteria to humans and plays a key role in various ...
Yoshimitsu Kakuta, Masahiko Negishi, Lars Pedersen   +2 more
exaly   +4 more sources

Enhanced locomotor recovery in mice lacking GlcNAc6ST1 and GlcNAc6ST4 following spinal cord injury [PDF]

Life Science Alliance
Mice lacking both GlcNAc6ST1 and GlcNAc6ST4 exhibit improved spinal cord injury recovery, with fewer monocytes and activated microglia at the injury sites and increased serotonergic neural fibers.
Masayoshi Morozumi, Tomoya Ozaki, Kazuchika Nishitsuji, Yoshiko Takeda-Uchimura, Akiyuki Matsumoto, Sadayuki Ito, Shiro Imagama, Naoki Ishiguro, Hirokazu Yagi, Koichi Kato, Tomoya O Akama, Tomoki Kosugi, Shoichi Maruyama, Kenji Kadomatsu, Steven D Rosen, Linda J Noble-Haeusslein, Kenji Uchimura   +16 more
doaj   +2 more sources

Identification of Human Sulfotransferases Active towards Silymarin Flavonolignans and Taxifolin [PDF]

Metabolites, 2020
Natural phenolic compounds are known to be metabolized by phase II metabolic reactions. In this study, we examined the in vitro sulfation of the main constituents of silymarin, an herbal remedy produced from the fruits of the milk thistle.
Jiří Vrba, Barbora Papoušková, Pavel Kosina, Kateřina Lněničková, Kateřina Valentová, Jitka Ulrichová   +5 more
doaj   +2 more sources

Giantin mediates Golgi localization of Gal3-O-sulfotransferases and affects salivary mucin sulfation in patients with Sjögren’s disease [PDF]

JCI Insight
Sjögren’s disease is a chronic autoimmune disease characterized by symptoms of oral and ocular dryness and extraglandular manifestations. Mouth dryness is not only due to reduced saliva volume, but also to alterations in the quality of salivary mucins in
Matilde Nuñez, Patricia Carvajal, Sergio Aguilera, María-José Barrera, Soledad Matus, Alicia Couto, Malena Landoni, Gaelle Boncompain, Sergio González, Claudio Molina, Karina Pino, Sebastián Indo, Lourdes Figueroa, María-Julieta González, Isabel Castro   +14 more
doaj   +2 more sources