Engineering Chondroitinase‐Free Baculovirus‐Insect Cell Expression System for Efficient Synthesis of Chondroitin Sulphates [PDF]
Microbial BiotechnologyOwing to the high expression levels, proper protein folding and post‐translational modifications, baculovirus‐insect cell expression system is an ideal platform for producing active chondroitin sulfotransferases, which specifically catalyse the synthesis
Junyue Li +9 more
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Identification and evolution of the plant sulfotransferase family [PDF]
BMC GenomicsSulfotransferases (SOTs, EC 2.8.2.-), which catalyze sulfate conjugation reactions, are widespread across prokaryotes and eukaryotes. However, the origin, classification and evolution history of SOTs in plants are not as well understood as those in ...
Shuangxin Han +12 more
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Chemically guided single-cell transcriptomics reveals sulfotransferase-mediated scaffold remodeling in securinine biosynthesis [PDF]
Nature CommunicationsSecurinega alkaloids possess a distinctive tetracyclic scaffold and are pharmaceutically relevant, yet their biosynthesis in Flueggea suffruticosa remains unresolved.
Sungjun Choung +10 more
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Probing sulfotransferase binding and inhibition with synthetic PAPS analogs reveals the role of the 3′-phosphate and informs molecular tool design [PDF]
RSC Chemical BiologySulfotransferases (STs) are a class of enzymes that catalyze the transfer of the sulfuryl group (–SO3−), most commonly from the universal cofactor 3′-phosphoadenosine 5′-phosphosulfate (PAPS), to nucleophilic acceptors bearing hydroxyl or amino groups ...
Maria Matveeva +6 more
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Structure and Function of Sulfotransferases [PDF]
Archives of Biochemistry and Biophysics, 2001 Sulfotransferases (STs) catalyze the transfer reaction of the sulfate group from the ubiquitous donor 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to an acceptor group of numerous substrates. This reaction, often referred to as sulfuryl transfer, sulfation, or sulfonation, is widely observed from bacteria to humans and plays a key role in various ...
Yoshimitsu Kakuta +2 more
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Identification and Characterization of Two Aryl Sulfotransferases from Deep-Sea Marine Fungi and Their Implications in the Sulfation of Secondary Metabolites [PDF]
Marine DrugsSulfation plays a critical role in the biosynthesis of small molecules, regulatory mechanisms such as hormone signaling, and detoxification processes (phase II enzymes).
Nicolas Graziano +11 more
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Microbiome-dependent phytosterol sulfates production and tissue distribution in mice [PDF]
iScienceSummary: Microbial biotransformation of dietary lipids, such as cholesterol, influences host homeostasis. Despite extensive studies on animal sterols in host-microbiota interactions, the role of phytosterols in homeostasis remains unclear. In this study,
Koki Tomita +4 more
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Sulfotransferase signaling sustains fibroblast identity and antagonizes therapeutic cardiac reprogramming [PDF]
Nature CommunicationsDifferentiated cells maintain their identity through active mechanisms that suppress alternative cell fates, but disrupting these barriers can enhance direct reprogramming for organ repair.
Michaela R. Romero +19 more
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Enhanced locomotor recovery in mice lacking GlcNAc6ST1 and GlcNAc6ST4 following spinal cord injury [PDF]
Life Science AllianceMice lacking both GlcNAc6ST1 and GlcNAc6ST4 exhibit improved spinal cord injury recovery, with fewer monocytes and activated microglia at the injury sites and increased serotonergic neural fibers.
Masayoshi Morozumi +16 more
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SULFUR CONTAINING MINERAL WATER AS A DIETARY FACTOR CHALLENGING THE PHASE II DETOXIFICATION ENZYMES IN HUMAN INTESTINAL CELLS [PDF]
Journal of IMAB, 2022 Introduction: According to the scientific literature, sulfur contained in various foods and medicines is almost completely absorbed in the gastrointestinal tract.
Todorka Sokrateva +5 more
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