Results 21 to 30 of about 7,639 (223)
Alignment of five sulfotransferases.
, 2022 Amino acid sequence alignment of Renilla Coel_ST 4A with the four sulfotransferases assayed. The sequence similarity of all 5 sulfotransferases is indicated by color highlighting.
Ira Schildkraut (29742) +7 more
core +1 more source
Exploiting Substrate Specificities of 6‑O‑Sulfotransferases to Enzymatically Synthesize Keratan Sulfate Oligosaccharides [PDF]
JACS Au, 2023 Keratan sulfate (KS) is a glycosaminoglycan that is widely expressed in the extracellular matrix of various tissue types, where it is involved in many biological processes.
Yunfei Wu +7 more
doaj +2 more sources
Impaired Sulfate Metabolism and Epigenetics: Is There a Link in Autism?
Entropy, 2012 Autism is a brain disorder involving social, memory, and learning deficits, that normally develops prenatally or early in childhood. Frustratingly, many research dollars have as yet failed to identify the cause of autism.
Samantha Hartzell, Stephanie Seneff
doaj +1 more source
mSphere, 2020 Total biosynthesis or whole-cell biocatalytic production of sulfated small molecules relies on the discovery and implementation of appropriate sulfotransferase enzymes.
Linan Xie +10 more
doaj +1 more source
Schistosome Sulfotransferases: Mode of Action, Expression and Localization
Pharmaceutics, 2022 Oxamniquine (OXA) is a prodrug activated by a sulfotransferase (SULT) that was only active against Schistosoma mansoni. We have reengineered OXA to be effective against S. haematobium and S. japonicum.
Meghan A. Guzman +10 more
doaj +1 more source
Engineering sulfotransferases to modify heparan sulfate [PDF]
, 2008 The biosynthesis of heparan sulfate (HS), an essential glycan in many organisms, involves an array of specialized sulfotransferases. Here, we present a study aimed at engineering the substrate specificity of different HS 3-O-sulfotransferase isoforms ...
Moon, Andrea F +9 more
core +1 more source
The host cell sulfonation pathway contributes to retroviral infection at a step coincident with provirus establishment. [PDF]
PLoS Pathogens, 2008 The early steps of retrovirus replication leading up to provirus establishment are highly dependent on cellular processes and represent a time when the virus is particularly vulnerable to antivirals and host defense mechanisms.
James W Bruce +2 more
doaj +1 more source
The role of heparan sulfate maturation in cancer: A focus on the 3O-sulfation and the enigmatic 3O-sulfotransferases (HS3STs) [PDF]
, 2019 peer reviewedHeparansulfate (HS) modifications are master regulators of the cross-talk between cell and matrix and modulate the biological activity of an array of HS binding proteins, including growth factors and chemokines, morphogens and immunity cell ...
Gulberti, Sandrine +3 more
core +1 more source
The Significance of the Sulfatase Pathway for Local Estrogen Formation in Endometrial Cancer
Frontiers in Pharmacology, 2017 Endometrial cancer (EC) is the most common estrogen-dependent gynecological malignancy in the developed World. To investigate the local formation of estradiol (E2), we first measured the concentrations of the steroid precursor androstenedione (A-dione ...
Maša Sinreih +7 more
doaj +1 more source
Plants, 2021 Various kinds of primary metabolisms in plants are modulated through sulfate metabolism, and sulfotransferases (SOTs), which are engaged in sulfur metabolism, catalyze sulfonation reactions.
Sahar Faraji +5 more
doaj +1 more source