Results 21 to 30 of about 7,003 (228)

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Inhibition of Human Sulfotransferases by Phthalate Monoesters

Frontiers in Endocrinology, 2022
ObjectiveThis study aimed to investigate the inhibition of human important phase II metabolic enzyme sulfotransferases (SULTs) by phthalate monoesters, which are important metabolites of phthalate esters (PAEs).MethodRecombinant SULT-catalyzed metabolism
Hui Huang, Bei-Di Lan, Yu-Jing Zhang, Xiao-Juan Fan, Min-Cui Hu, Guo-Qiang Qin, Fei-Ge Wang, Yue Wu, Tao Zheng, Jun-Hui Liu, Jun-Hui Liu   +10 more
doaj   +1 more source

Impaired Sulfate Metabolism and Epigenetics: Is There a Link in Autism?

Entropy, 2012
Autism is a brain disorder involving social, memory, and learning deficits, that normally develops prenatally or early in childhood. Frustratingly, many research dollars have as yet failed to identify the cause of autism.
Samantha Hartzell, Stephanie Seneff
doaj   +1 more source

Combinatorial Biosynthesis of Sulfated Benzenediol Lactones with a Phenolic Sulfotransferase from Fusarium graminearum PH-1

mSphere, 2020
Total biosynthesis or whole-cell biocatalytic production of sulfated small molecules relies on the discovery and implementation of appropriate sulfotransferase enzymes.
Linan Xie, Dongliang Xiao, Xiaojing Wang, Chen Wang, Jing Bai, Qun Yue, Haitao Yue, Ye Li, István Molnár, Yuquan Xu, Liwen Zhang   +10 more
doaj   +1 more source

Schistosome Sulfotransferases: Mode of Action, Expression and Localization

Pharmaceutics, 2022
Oxamniquine (OXA) is a prodrug activated by a sulfotransferase (SULT) that was only active against Schistosoma mansoni. We have reengineered OXA to be effective against S. haematobium and S. japonicum.
Meghan A. Guzman, Anastasia Rugel, Sevan N. Alwan, Reid Tarpley, Alexander B. Taylor, Frédéric D. Chevalier, George R. Wendt, James J. Collins, Timothy J. C. Anderson, Stanton F. McHardy, Philip T. LoVerde   +10 more
doaj   +1 more source

The host cell sulfonation pathway contributes to retroviral infection at a step coincident with provirus establishment. [PDF]

PLoS Pathogens, 2008
The early steps of retrovirus replication leading up to provirus establishment are highly dependent on cellular processes and represent a time when the virus is particularly vulnerable to antivirals and host defense mechanisms.
James W Bruce, Paul Ahlquist, John A T Young   +2 more
doaj   +1 more source

Engineering sulfotransferases to modify heparan sulfate [PDF]

, 2008
The biosynthesis of heparan sulfate (HS), an essential glycan in many organisms, involves an array of specialized sulfotransferases. Here, we present a study aimed at engineering the substrate specificity of different HS 3-O-sulfotransferase isoforms ...
Moon, Andrea F, Andrea F Moon, Xu, Ding, Pedersen, Lars C, Liu, Jian, Lars C Pedersen, Ding Xu, Jian Liu, Danyin Song, Song, Danyin   +9 more
core   +2 more sources

The Significance of the Sulfatase Pathway for Local Estrogen Formation in Endometrial Cancer

Frontiers in Pharmacology, 2017
Endometrial cancer (EC) is the most common estrogen-dependent gynecological malignancy in the developed World. To investigate the local formation of estradiol (E2), we first measured the concentrations of the steroid precursor androstenedione (A-dione ...
Maša Sinreih, Tamara Knific, Maja Anko, Neli Hevir, Katja Vouk, Aleš Jerin, Snježana Frković Grazio, Tea Lanišnik Rižner   +7 more
doaj   +1 more source

Investigation and Computational Analysis of the Sulfotransferase (SOT) Gene Family in Potato (Solanum tuberosum): Insights into Sulfur Adjustment for Proper Development and Stimuli Responses

Plants, 2021
Various kinds of primary metabolisms in plants are modulated through sulfate metabolism, and sulfotransferases (SOTs), which are engaged in sulfur metabolism, catalyze sulfonation reactions.
Sahar Faraji, Parviz Heidari, Hoorieh Amouei, Ertugrul Filiz, Abdullah, Peter Poczai   +5 more
doaj   +1 more source

Steroid Sulfation in Neurodegenerative Diseases

Frontiers in Molecular Biosciences, 2022
Steroid sulfation and desulfation participates in the regulation of steroid bioactivity, metabolism and transport. The authors focused on sulfation and desulfation balance in three neurodegenerative diseases: Alzheimer´s disease (AD), Parkinson´s disease
Jana Vitku, Martin Hill, Lucie Kolatorova, Eva Kubala Havrdova, Radmila Kancheva   +4 more
doaj   +1 more source