Results 41 to 50 of about 7,639 (223)
Structural and functional characterisation of human sulfotransferases [PDF]
, 1998 The human aryl sulfotransferases HAST4 and HAST4v vary by only two amino acids but exhibit markedly different affinity towards the sulfonate acceptor p-nitrophenol and the sulfonate donor 3'-phosphoadenosine-5'-phosphosulfate (PAPS).
McManus, M. E. +3 more
core +1 more source
Chondroitin / dermatan sulfate modification enzymes in zebrafish development.
PLoS ONE, 2015 Chondroitin/dermatan sulfate (CS/DS) proteoglycans consist of unbranched sulfated polysaccharide chains of repeating GalNAc-GlcA/IdoA disaccharide units, attached to serine residues on specific proteins.
Judith Habicher +6 more
doaj +1 more source
Identification of Human Sulfotransferases Active towards Silymarin Flavonolignans and Taxifolin
Metabolites, 2020 Natural phenolic compounds are known to be metabolized by phase II metabolic reactions. In this study, we examined the in vitro sulfation of the main constituents of silymarin, an herbal remedy produced from the fruits of the milk thistle.
Jiří Vrba +5 more
doaj +1 more source
Carrageenan biosynthesis in red algae: A review
The Cell Surface, 2023 In this review, we summarize the current state of knowledge on the biosynthesis of carrageenan by exploring both the enzyme activities and their localizations.
Antonin Chevenier +2 more
doaj +1 more source
Computational Analysis of Chemical Space of Natural Compounds Interacting with Sulfotransferases
Molecules, 2021 The aim of this study was to investigate the chemical space and interactions of natural compounds with sulfotransferases (SULTs) using ligand- and structure-based in silico methods.
Iglika Lessigiarska +10 more
doaj +1 more source
, 1996 Photoaffinity labeling with 2-azidoadenosine 3′,5′-[5′-P]bisphosphate was used to identify and characterize adenosine 3′,5′-bisphosphate-binding proteins in human liver cytosol and recombinant sulfotransferase proteins. The sulfotransferases investigated
Veronese, Maurice E. +17 more
core +1 more source
Understanding the substrate specificity of the heparan sulfate sulfotransferases by an integrated biosynthetic and crystallographic approach [PDF]
, 2012 Heparan sulfates (HSs) have potential therapeutic value as anti-inflammatory and antimetastasis drugs, in addition to their current use as anticoagulants.
Moon, Andrea +3 more
core +1 more source
Carbohydrate sulfotransferases: mediators of extracellular communication
, 1999 Sulfated carbohydrates mediate diverse extracellular recognition events in both normal and pathological processes. The sulfotransferases that generate specific carbohydrate ‘sulfoforms’ have recently been recognized as key modulators of these processes ...
Bowman, Kendra G, Bertozzi, Carolyn R
core +1 more source
Frontiers in Cell and Developmental Biology, 2020 Heparan sulfate (HS) is a glycosaminoglycan found mainly in its protein-conjugated form at the cell surface and the extracellular matrix. Its high sulfation degree mediates functional interactions with positively charged amino acids in proteins.
Felipe C. O. B. Teixeira +11 more
doaj +1 more source
Advanced Science, EarlyView.Proposed model of CHST1‐associated immune remodeling in triple‐negative breast cancer. In CHST1‐low tumors, greater nuclear accumulation of NKRF is associated with repression of an NF‐κB‐related CCL20 transcriptional program and an immune‐inflamed microenvironment.
Shu‐Hao Jiang +6 more
wiley +1 more source