Results 41 to 50 of about 7,003 (228)

Sugar glues for broken neurons

Biomolecular Concepts, 2013
Proteoglycans (PGs) regulate diverse functions in the central nervous system (CNS) by interacting with a number of growth factors, matrix proteins, and cell surface molecules.
Swarup Vimal P., Mencio Caitlin P., Hlady Vladimir, Kuberan Balagurunathan   +3 more
doaj   +1 more source

Structure–activity relationships and interindividual variability of drug responses: pharmacogenomics with antimicrobial drugs as a paradigm

Journal of International Medical Research, 2023
Adverse drug reactions represent a major health burden because they cause notable patient morbidity and mortality. From this viewpoint, several strategies have been developed to prevent or reduce adverse drug reactions.
Romany H. Thabet, Bayan Osama Shehadeh Alshar, Doaa Habes Saleh Alabdallah, Nour Alhuda Zaid Ahmad Alhmoud, Sondos Taher Abdalsalam Alslameen, Youssef Romany Helmy Thabet   +5 more
doaj   +1 more source

Sulfuryl group transfer from coelenterazine sulfate to PAP by other sulfotransferases. [PDF]

, 2022
We surveyed four sulfotransferases (STs) for their ability to transfer the sulfate from coelenterazine sulfate to PAP producing coelenterazine. The mouse estrogen ST was chosen based on sequence similarity (Fig 9) to the Coel-ST and the others based on ...
Ira Schildkraut (29742), Ivan R. Corrêa Jr. (11083985), Laurence Ettwiller (15718), George Tzertzinis (154499), Jack Benner (9571), Elizabeth Brown (281332), Colleen McClung (3402752), Brenda Baker (174368)   +7 more
core   +1 more source

Chondroitin / dermatan sulfate modification enzymes in zebrafish development.

PLoS ONE, 2015
Chondroitin/dermatan sulfate (CS/DS) proteoglycans consist of unbranched sulfated polysaccharide chains of repeating GalNAc-GlcA/IdoA disaccharide units, attached to serine residues on specific proteins.
Judith Habicher, Tatjana Haitina, Inger Eriksson, Katarina Holmborn, Tabea Dierker, Per E Ahlberg, Johan Ledin   +6 more
doaj   +1 more source

Bioinformatic Analysis of Sulfotransferases from an Unexplored Gut Microbe, Sutterella wadsworthensis 3_1_45B: Possible Roles towards Detoxification via Sulfonation by Members of the Human Gut Microbiome. [PDF]

Int J Mol Sci
Sulfonation, primarily facilitated by sulfotransferases, plays a crucial role in the detoxification pathways of endogenous substances and xenobiotics, promoting metabolism and elimination. Traditionally, this bioconversion has been attributed to a family
Langford L, Shah DD.
europepmc   +2 more sources

Carrageenan biosynthesis in red algae: A review

The Cell Surface, 2023
In this review, we summarize the current state of knowledge on the biosynthesis of carrageenan by exploring both the enzyme activities and their localizations.
Antonin Chevenier, Diane Jouanneau, Elizabeth Ficko-Blean   +2 more
doaj   +1 more source

Computational Analysis of Chemical Space of Natural Compounds Interacting with Sulfotransferases

Molecules, 2021
The aim of this study was to investigate the chemical space and interactions of natural compounds with sulfotransferases (SULTs) using ligand- and structure-based in silico methods.
Iglika Lessigiarska, Yunhui Peng, Ivanka Tsakovska, Petko Alov, Nathalie Lagarde, Dessislava Jereva, Bruno O. Villoutreix, Arnaud B. Nicot, Ilza Pajeva, Tania Pencheva, Maria A. Miteva   +10 more
doaj   +1 more source

PPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression [PDF]

, 2008
Background The selective absorption of nutrients and other food constituents in the small intestine is mediated by a group of transport proteins and metabolic enzymes, often collectively called 'intestinal barrier proteins'.
Hooiveld, Guido J E J, Bosch, H.M., van den, de Groot, Philip, de Vogel-van den Bosch, Heleen, de Groot Philip J, de Groot, P.J., Hooiveld Guido JEJ, de Vogel-van den Bosch Heleen M, Müller, M.R., Bosch-Vermeulen, Hanneke, Heleen M de Vogel-van den Bosch, Hooiveld, Guido, Bosch - Vermeulen, Hanneke, Philip J de Groot, Bünger, Meike, Bosch-Vermeulen Hanneke, Bünger Meike, de Vogel-van den Bosch, Heleen M, Müller Michael, Müller, Michael, Meike Bünger, Michael Müller, Hanneke Bosch-Vermeulen, Bosch-Vermeulen, H., van den Bosch, H.M., Bünger, M., Groot, P.J., de, Guido JEJ Hooiveld, Heleen M de Vogel-van den Bosch, Hooiveld, G.J.E.J., de Groot, Philip J   +30 more
core   +1 more source

Exploiting Substrate Specificities of 6‑O‑Sulfotransferases to Enzymatically Synthesize Keratan Sulfate Oligosaccharides [PDF]

JACS Au, 2023
Keratan sulfate (KS) is a glycosaminoglycan that is widely expressed in the extracellular matrix of various tissue types, where it is involved in many biological processes.
Yunfei Wu, Gaël M. Vos, Chin Huang, Digantkumar Chapla, Anne L. M. Kimpel, Kelley W. Moremen, Robert P. de Vries, Geert-Jan Boons   +7 more
doaj   +2 more sources

HS sulfotransferases are increased in AD hippocampus. [PDF]

, 2019
a) The expression of the main HS sulfotransferases responsible of N-, 2-O-, 3-O- and 6-O-sulfation were examined by RTqPCR. Other genes were analyzed including C5-epimerase (GLCE), heparanase (HPSE) and carbohydrate sulfotransferase 8 (CHST8).
Rita Raisman-Vozari (262104), Gilles Carpentier (306469), Ganlin Zhang (815097), Mohand Ouidir Ouidja (6175700), Auriane Maïza (4356847), Joao Vilares (6175703), Minh Bao Huynh (6175697), Dulce Papy-Garcia (686114), Sandrine Chantepie (297447)   +8 more
core   +1 more source