Results 61 to 70 of about 7,639 (223)

A proteomic investigation of forebrain regeneration in the leopard gecko (Eublepharis macularius)

Developmental Dynamics, EarlyView.
Our investigation reveals ontogenetic, injury‐ and regeneration‐associated proteomic changes in the leopard gecko forebrain. Abstract Background The ability to replace lost or damaged neurons following an injury is termed reactive neurogenesis. Although reactive neurogenesis has been reported in several lizard species, the molecular mechanisms ...
Alexandra I. Noble, Samantha L. Payne, Matthew K. Vickaryous   +2 more
wiley   +1 more source

3-O-sulfated heparan sulfate recognized by the antibody HS4C3 contributes [corrected] to the differentiation of mouse embryonic stem cells via fas signaling.

PLoS ONE, 2012
Maintenance of self-renewal and pluripotency in mouse embryonic stem cells (mESCs) is regulated by the balance between several extrinsic signaling pathways.
Kazumi Hirano, Norihiko Sasaki, Tomomi Ichimiya, Taichi Miura, Toin H Van Kuppevelt, Shoko Nishihara   +5 more
doaj   +1 more source

CD8+ T‐cells, CD86+ macrophages and TNF‐α signalling pathways are correlated with fetlock osteoarthritis in racehorses

Equine Veterinary Journal, EarlyView.
Abstract Background There is emerging evidence for the role of the immune system in osteoarthritis (OA) pathophysiology; however, little is known about how immune cells and the synovial transcriptome are altered in naturally occurring equine OA. Objectives To evaluate synovial fluid (SF) and synovial membrane (SM) immune cell populations and the SM ...
E. J. Secor, E. N. Chow, M. Thomas, L. Johnson, A. Siefert, B. Wagner, J. B. Engiles, H. L. Reesink   +7 more
wiley   +1 more source

Synthesis of heparan sulfate with cyclophilin B-binding properties is determined by cell type-specific expression of sulfotransferases.

, 2010
Contains fulltext : 89091.pdf (Publisher’s version ) (Open Access)Cyclophilin B (CyPB) induces migration and adhesion of T lymphocytes via a mechanism that requires interaction with 3-O-sulfated heparan sulfate (HS).
Deligny, A., Kuppevelt, A.H.M.S.M. van, Marcant, A., Denys, A., Melchior, A., Mazurier, J., Allain, F.   +6 more
core   +1 more source

Structural and chemical profiling of the human cytosolic sulfotransferases.

PLoS Biology, 2007
The human cytosolic sulfotransfases (hSULTs) comprise a family of 12 phase II enzymes involved in the metabolism of drugs and hormones, the bioactivation of carcinogens, and the detoxification of xenobiotics.
Abdellah Allali-Hassani, Patricia W Pan, Ludmila Dombrovski, Rafael Najmanovich, Wolfram Tempel, Aiping Dong, Peter Loppnau, Fernando Martin, Janet Thornton, Aled M Edwards, Alexey Bochkarev, Alexander N Plotnikov, Masoud Vedadi, Cheryl H Arrowsmith   +13 more
doaj   +1 more source

Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase‐catalyzed xanthine and 6‐mercaptopurine oxidation

Journal of the Science of Food and Agriculture, Volume 105, Issue 5, Page 2765-2776, 30 March 2025.
Abstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Tímea Bencsik, Orsolya Balázs, Róbert G Vida, Balázs Z Zsidó, Csaba Hetényi, Kateřina Valentová, Miklós Poór   +6 more
wiley   +1 more source

Sulfotransferase and Heparanase: Remodeling Engines in Promoting Virus Infection and Disease Development

Frontiers in Pharmacology, 2018
An extraordinary binding site generated in heparan sulfate (HS) structures, during its biosynthesis, provides a unique opportunity to interact with multiple protein ligands including viral proteins, and therefore adds tremendous value to this master ...
Dominik D. Kaltenbach, Dinesh Jaishankar, Meng Hao, Jacob C. Beer, Michael V. Volin, Umesh R. Desai, Vaibhav Tiwari   +6 more
doaj   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Human phenol sulfotransferases hP-PST and hM-PST activate propane 2-nitronate to a genotoxicant.

, 2000
The industrial solvent 2-nitropropane (2-NP) is a genotoxic hepatocarcinogen in rats. The genotoxicity of the compound in rats has been attributed to sulfotransferase-mediated formation of DNA-reactive nitrenium ions from the anionic form of 2-NP ...
Pabel, U., Brandner, S., Kreis, P., Coughtrie, M.W., Glatt, H., Meinl, W., Andrae, U., P. Kreis   +7 more
core   +1 more source

Sulfotransferases in mediating the chlorophenol metabolism: Metabolites identification and metabolic characterization

Journal of Hazardous Materials Letters
Chlorophenols (CPs) are persistent organic pollutants (POPs) widely detected in the natural environment. Sulfotransferases are a group of crucial phase II metabolic enzyme involved in the metabolism of endogenous and exogenous substances.
Kai Yang, Guoqiang qin, RuoYong Jia, Haoqian Zhang, Qiangqiang Gan, Shao-You Lu, Jian-Jun Liu, Zhong-Ze Fang   +7 more
doaj   +1 more source