Results 81 to 90 of about 7,003 (228)
Sulfation of sialic acid is ubiquitous and essential for vertebrate development
Scientific Reports, 2022 Glycosylation of proteins and lipids occurs in vertebrates, usually terminating with sialylation, which regulates the physicochemical and biological properties of these glycoconjugates.
Nursah Ertunc +6 more
doaj +1 more source
Keratinocyte Priming by Staphylococcus aureus Reduces HSV‐1 Susceptibility
Allergy, EarlyView.ADEH+ patients have a reduced microbial diversity with increased S. aureus and S. epidermidis colonization compared to ADEH− and healthy controls. Heat‐killed S. aureus reduced HSV‐1 susceptibility and release of infectious progeny virus in a keratinocyte in vitro model. Heat‐killed S.
Phila Cara Baumann +19 more
wiley +1 more source
Saccharomyces cerevisiae as a Host for Chondroitin Production
SynBioChondroitin is a glycosaminoglycan that has gained widespread use in nutraceuticals and pharmaceuticals, mainly for treating osteoarthritis. Traditionally, it has been extracted from animal cartilage but recently, biotechnological processes have emerged ...
Márcia R. Couto +3 more
doaj +1 more source
Frontiers in Plant Science, 2015 Many algae are rich sources of sulfated polysaccharides with biological activities. The physicochemical/rheological properties and biological activities of sulfated polysaccharides are affected by the pattern and number of sulfate moieties.
Chai-Ling eHo
doaj +1 more source
Genetic risk factors in Finnish patients with Fuchs endothelial corneal dystrophy
Acta Ophthalmologica, EarlyView.Abstract Purpose To study the genetic risk factors of Fuchs endothelial corneal dystrophy (FECD) in the Finnish population using hospital‐based and large biobank cohorts. Methods We genotyped a cohort of 107 Finnish patients with FECD for the primary associated genetic risk factor, the TCF4 (CTG)>50 expansion, and studied their clinical phenotype.
Inka‐Tuulevi Vähämäki +10 more
wiley +1 more source
Garadacimab for the long‐term prophylaxis of hereditary angioedema
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.Summary Hereditary angioedema (HAE), a rare and debilitating disease characterized by recurrent and spontaneous attacks of tissue swelling, has a high unmet therapeutic need, with many patients experiencing insufficient disease control with current prophylactic treatments.
Emel Aygören‐Pürsün +5 more
wiley +1 more source
Monoamine Neurotransmitters as Substrates for Novel Tick Sulfotransferases, Homology Modeling, Molecular Docking, and Enzyme Kinetics [PDF]
, 2010 Blacklegged ticks (Ixodes scapularis) transmit the causative agent of Lyme disease in the Northeastern United States. Current research focuses on elucidating biochemical pathways that may be disrupted to prevent pathogen transmission, thereby preventing ...
Roberta S. King +9 more
core +2 more sources
Genome mining of sulfonated lanthipeptides reveals unique cyclic peptide sulfotransferases
Acta Pharmaceutica Sinica BAlthough sulfonation plays crucial roles in various biological processes and is frequently utilized in medicinal chemistry to improve water solubility and chemical diversity of drug leads, it is rare and underexplored in ribosomally synthesized and post ...
Meng Wang +9 more
doaj +1 more source
The FEBS Journal, EarlyView.Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo +4 more
wiley +1 more source
REVIEW Human Sulfotransferases and Their Role in Chemical Metabolism [PDF]
, 2020 Sulfonation is an important reaction in the metabolism of numerous xenobiotics, drugs, and endogenous compounds. A supergene family of enzymes called sulfotransferases (SULTs) catalyze this reaction. In most cases, the addition of a sulfonate moiety to a
Ronald G Duggleby +6 more
core