Results 81 to 90 of about 7,639 (223)
Frontiers in Plant Science, 2015 Many algae are rich sources of sulfated polysaccharides with biological activities. The physicochemical/rheological properties and biological activities of sulfated polysaccharides are affected by the pattern and number of sulfate moieties.
Chai-Ling eHo
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Plant Breeding, EarlyView.ABSTRACT Enhancing nutritional quality of oilseed rape requires deeper insight into the genetic control of seed quality traits. This study analysed the effect of varying soil phosphorus (P) levels on seed quality traits in the hybrid cultivar Architect. NIRS and laboratory methods were used to quantify total seed P and phytic acid (IP6) content.
Jasmin Vettel +2 more
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Genome mining of sulfonated lanthipeptides reveals unique cyclic peptide sulfotransferases
Acta Pharmaceutica Sinica BAlthough sulfonation plays crucial roles in various biological processes and is frequently utilized in medicinal chemistry to improve water solubility and chemical diversity of drug leads, it is rare and underexplored in ribosomally synthesized and post ...
Meng Wang +9 more
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Physiological and anatomical determinants of placental drug transfer
The Journal of Physiology, EarlyView.Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis +3 more
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The Journal of Physiology, EarlyView.Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor +4 more
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In silico mechanistic profiling to probe small molecule binding to sulfotransferases.
PLoS ONE, 2013 Drug metabolizing enzymes play a key role in the metabolism, elimination and detoxification of xenobiotics, drugs and endogenous molecules. While their principal role is to detoxify organisms by modifying compounds, such as pollutants or drugs, for a ...
Virginie Y Martiny +5 more
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Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies
The Journal of Physiology, EarlyView.Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu +3 more
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Signal Transduction and Targeted TherapyImmunostaining in lungs of patients who died with COVID-19 infection showed increased intensity and distribution of chondroitin sulfate and decline in N-acetylgalactostamine-4-sulfatase (Arylsulfatase B; ARSB).
Sumit Bhattacharyya, Joanne K. Tobacman
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Genome‐wide prediction of cloned disease resistance homologues across the Oryza genus
The Plant Genome, Volume 19, Issue 4, December 2026.Abstract The wild relatives of rice (Oryza sativa L.) represent reservoirs of genetic diversity and potential sources of novel pest and disease resistance. The recent availability of high‐quality Oryza genome assemblies has enabled greater exploration of this diversity across the genus.
Sabrina Morrison +4 more
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Frontiers in Pharmacology, 2017 In recent years, a growing appreciation has developed for the importance of protein-protein interactions to modulate the function of drug metabolizing enzymes.
Jed N. Lampe
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