Results 101 to 110 of about 7,639 (223)

Structural insights into tyrosine sulfation of CCR5 by human tyrosylprotein sulfotransferase‐1

The FEBS Journal, Volume 293, Issue 21, Page 6552-6568, November 2026.
Post‐translational sulfation of the chemokine receptor CCR5 is involved in crucial biological processes such as viral infection and chemokine signaling. This sulfation is catalyzed by human tyrosylprotein sulfotransferases (hTPSTs) within the Golgi lumen. However, the detailed molecular mechanism remains unresolved.
Shinnosuke Tanaka, Hirai Asano, Kota Toyoda, Toshiaki Nishiyori, Hidetaka Kojo, Kazuto Kiyomatsu, Katsuhisa Kurogi, Yoichi Sakakibara, Etsuko Nishimoto, Takamasa Teramoto, Yoshimitsu Kakuta   +10 more
wiley   +1 more source

Characterization of dermatan sulfate and chondroitin sulfate profiles during brain regeneration in Styela plicata

The FEBS Journal, Volume 293, Issue 21, Page 6569-6585, November 2026.
Adult ascidians are capable of regenerating their entire brains following injury, and glycosaminoglycans have been shown to either promote or inhibit neuritogenesis. In this study, dermatan 2,6‐disulfate (D2,6S) was identified as the predominant complex carbohydrate in the ascidian brain.
Taynan Motta Portal, Samara de Oliveira Pimentel, Bruno da Costa Rodrigues, Mauro Sérgio Gonçalves Pavão, Rodrigo Nunes da Fonseca, Cintia Monteiro de Barros   +5 more
wiley   +1 more source

Interaction of the brain-selective sulfotransferase SULT4A1 with other cytosolic sulfotransferases: effects on protein expression and function

, 2020
Sulfotransferase (SULT) 4A1 is a brain-selective sulfotransferase-like protein that has recently been shown to be essential for normal neuronal development in mice.
Idris, Misgana, Mitchell, Deanne J., Gordon, Richard, Sidharthan, Neelima P., Minchin, Rodney F., Butcher, Neville J.   +5 more
core   +1 more source

The Maternal Blood Transcriptome Reflects Molecular Signatures Associated With Large Offspring Syndrome and Other Adverse Pregnancy Outcomes in Cattle

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Blood samples from pregnant heifers carrying in vitro‐produced embryos were analyzed for RNA‐sequencing to test whether maternal blood transcriptome could be predictive of large offspring syndrome, stillbirth, and abortion compared with controls.
Tatiane S. Maia, Maria B. Rabaglino, Rebecca Krisher, Paula Rodriguez‐Villamil, Jeniffer Pamela J. Laguna, Jeniffer F. Escoto, Yanping Zhang, Abigail J. Sproull, Peter J. Hansen   +8 more
wiley   +1 more source

Galactose 6-O-Sulfotransferases Are Not Required for the Generation of Siglec-F Ligands in Leukocytes or Lung Tissue [PDF]

, 2013
Eosinophil accumulation is a characteristic feature of the immune response to parasitic worms and allergens. The cell surface carbohydrate-binding receptor Siglec-F is highly expressed on eosinophils and negatively regulates their accumulation during ...
Steven D. Rosen, Cheng, Chu-Wen, Rosen, Steven D, Khoo, Kay-Hooi, Patnode, Michael L, Chi-Chi Chou, Mark S. Singer, Uchimura, Kenji, Michael L. Patnode, Crocker, Paul R, Kenji Uchimura, Kay-Hooi Khoo, Singer, Mark S, Chou, Chi-Chi, Paul R. Crocker, Chu-Wen Cheng, Matilda S. Elin, Elin, Matilda S   +17 more
core   +1 more source

Structural basis for the broad substrate specificity of the human tyrosylprotein sulfotransferase-1

Scientific Reports, 2017
Tyrosylprotein sulfotransferases (TPSTs) are enzymes that catalyze post-translational tyrosine sulfation of proteins. In humans, there are only two TPST isoforms, designated TPST1 and TPST2. In a previous study, we reported the crystal structure of TPST2,
Shinnosuke Tanaka, Toshiaki Nishiyori, Hidetaka Kojo, Reo Otsubo, Moe Tsuruta, Katsuhisa Kurogi, Ming-Cheh Liu, Masahito Suiko, Yoichi Sakakibara, Yoshimitsu Kakuta   +9 more
doaj   +1 more source

Endothelial Exostosin‐1 Is Needed for Glycocalyx Integrity and Inflammatory Resolution in Acute Lung Injury

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Endothelial Ext1 is essential for maintaining heparan sulfate–rich endothelial glycocalyx integrity. Loss of Ext1 reduces glycocalyx thickness, resulting in enhanced leukocyte adhesion, increased vascular permeability, and exaggerated inflammatory responses following lipopolysaccharide (LPS) challenge.
Yuki Kawasaki, Hiroyuki Tomita, Kodai Suzuki, Chihiro Takada, Hirotaka Asano, Soichiro Kano, Yugo Wakayama, Hirotsugu Fukuda, Toru Minamiyama, Genki Yoshimura, Ryo Kamidani, Yoshinori Kakino, Tomotaka Miura, Yuichiro Kitagawa, Tetsuya Fukuta, Takahito Miyake, Akio Suzuki, Kazu Matsumoto, Nobuyuki Tetsuka, Shozo Yoshida, Yoichi Maekawa, Yu Yamaguchi, Hideshi Okada   +22 more
wiley   +1 more source

Combinatorial effects of eliminating HS epimerase and O-sulfotransferases for neural migration.

, 2014
(A) Removal of HS 3- and 6-O-sulfotransferases enhances the defects in HS epimerase mutants. C. elegans with genetic deletion in either hst-3.1 or hst-6 or in combination of both have wild type HSN migration.
Tarja K. Kinnunen (602998)
core   +1 more source

Sulfotransferases: Genetics and role in toxicology.

, 2000
The mammalian xenobiotic-metabolizing sulfotransferases are cytosolic enzymes, which form a gene superfamily (SULT). Ten distinct human SULT forms are known. Two SULT forms represent splice variants, the other forms are encoded by separate genes.
Pabel, U., Falany, C.N., Teubner, W., Coughtrie, M.W., Glatt, H., Engelke, C.E., Jones, A.L., Andrae, U., Meinl, W., Ulrike Pabel, Charles N Falany, Ulrich Andrae, Walter Meinl, Alwen L Jones, Michael W.H Coughtrie, Hansruedi Glatt, Christina E.H Engelke, Wera Teubner   +17 more
core   +1 more source

Interethnic and interindividual variabilities of platelet sulfotransferases activity in Italians and Finns

, 1999
Objective: The aim of this investigation was to see whether there was interethnic variability in the platelet activities of catechol- and phenol sulfotransferases in Italians and Finns.
Rossi G, Raunio H, Brittelli A, De Santi C, Pelkonen O, Pacifici GM   +5 more
core