Results 111 to 120 of about 7,639 (223)

Structural Basis of Functional Group Activation by Sulfotransferases in Complex Metabolic Pathways

, 2016
Sulfated molecules with diverse functions are common in biology, but sulfonation as a method to activate a metabolite for chemical catalysis is rare. Catalytic activity was characterized and crystal structures were determined for two such “activating ...
Peter Wipf (134666), Eli B. Eisman (1931197), Janet L. Smith (213446), Lena Gerwick (224905), William H. Gerwick (176359), David H. Sherman (46395), Jennifer Gehret McCarthy (2009767), Sarang Kulkarni (15868)   +7 more
core   +1 more source

Cytosolic sulfotransferases

, 2006
171-182Sulfoconjugation (Sulfation or Sulfonation) is an important reaction in the phase II biotransformation of a wide number of endogenous and foreign chemicals, including: drugs, toxic chemicals, hormones, and neurotransmitters.
Ghatta, Srinivas, Nimmagadda, Deepthi, Cherala, Ganesh   +2 more
core  

Exploiting Substrate Specificities of 6‑O‑Sulfotransferases to Enzymatically Synthesize Keratan Sulfate Oligosaccharides

Keratan sulfate (KS) is a glycosaminoglycan that is widely expressed in the extracellular matrix of various tissue types, where it is involved in many biological processes.
Yunfei Wu (322866), Digantkumar Chapla (5637566), Chin Huang (14165326), Geert-Jan Boons (212062), Gaël M. Vos (8181414), Anne L. M. Kimpel (15369095), Kelley W. Moremen (2077327), Robert P. de Vries (9634995)   +7 more
core   +1 more source

Localisation of aryl sulfotransferase expression in human tissues using hybridisation histochemistry and immunohistochemistry

, 1998
To date, the laboratory has cloned seven unique human sulfotransferases; five aryl sulfotransferases (HAST1, HAST2, HAST3, HAST4 and HAST4v), an estrogen sulfotransferase and a dehydroepiandrosterone sulfotransferase.
XY Zhu (16081796), Kelly Windmill (13078617), ME McManus (17321848), DJ Birkett (17321845), JT Teusner (17321839), A Christiansen (17321836), CR Bhasker (17321842)   +6 more
core  

Inflammatory cues modulate the expression of secretory product genes, Golgi sulfotransferases and sulfomucin production in LS174T cells

, 2011
The signals that mediate goblet cell expression of specific mucin chemotypes are poorly defined. Animal and in vitro studies show that acidomucin chemotypes may be altered by inflammation and changes in intestinal microbiota. To examine factors that may
Shikha Bhatia, H Rex Gaskins, Jennifer A Croix   +2 more
core   +1 more source

Biosynthetic production of anticoagulant heparin polysaccharides through metabolic and sulfotransferases engineering strategies

Nature Communications
Heparin is an important anticoagulant drug, and microbial heparin biosynthesis is a potential alternative to animal-derived heparin production. However, effectively using heparin synthesis enzymes faces challenges, especially with microbial recombinant ...
Jian-Qun Deng, Yi Li, Yu-Jia Wang, Ya-Lin Cao, Si-Yu Xin, Xin-Yu Li, Rui-Min Xi, Feng-Shan Wang, Ju-Zheng Sheng   +8 more
doaj   +1 more source

Synergism of obesity genes with hepatic steroid sulfotransferases to mediate diabetes in mice.

, 1991
Sulfotransferases controlling the intrahepatic ratio of actve obesity mutation will be diabetogenic in C57BL/KsJ female mice. Three unlinked genes (diabetes [db], obese [ob], and fat [fat]) all produced comparable obesity in C57BL/KsJ females, but ...
Falany, C N, Leiter, E H, Chapman, H D
core   +1 more source

REVIEW Human Sulfotransferases and Their Role in Chemical Metabolism

, 2020
Sulfonation is an important reaction in the metabolism of numerous xenobiotics, drugs, and endogenous compounds. A supergene family of enzymes called sulfotransferases (SULTs) catalyze this reaction. In most cases, the addition of a sulfonate moiety to a
Ronald G Duggleby, Jennifer L Martin, Michael E Mcmanus, Niranjali Gamage, Amanda Barnett, Kelly F Windmill, Nadine Hempel   +6 more
core  

Developmental Expression of the Cytosolic Sulfotransferases in Human Liver.

, 2019
The liver is the predominant organ of metabolism for many endogenous and foreign chemicals. Cytosolic sulfotransferases (SULTs) catalyze the sulfonation of drugs and other xenobiotics, as well as hormones, neurotransmitters, and sterols, with ...
Dubaisi, Sarah, Gaedigk, R, Kocarek, Thomas A, Caruso, Joseph A, Vyhlidal, Carrie A, Smith, Philip C, Hines, Ronald N, Runge-Morris, Melissa   +7 more
core  

Perspectives of Bacterial PAPS-Independent Aryl Sulfotransferases for Practical In Vitro Sulfation. [PDF]

J Agric Food Chem
Brodsky K, Petránková B, Slámová K, Bojarová P, Valentová K.   +4 more
europepmc   +1 more source