Results 71 to 80 of about 7,639 (223)
The Emerging Roles of Heparan Sulfate 3-O-Sulfotransferases in Cancer
Frontiers in Oncology, 2019 Alteration in the expression of heparan sulfate (HS)-modifying enzymes has been frequently observed in cancer. Consequently, dysregulation of the HS biosynthetic machinery results in dramatic changes in the HS structure, thereby impacting a range of ...
Agnès Denys, Fabrice Allain
doaj +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Asthma affects 260–300 million people worldwide. About 20%–35% of patients use medicinal plants with their asthma medication, often without telling their clinicians. Disclosure rates are low; up to 42% of asthma outpatients use herbal products, with no records in their charts.
Emine Kocyigit +5 more
wiley +1 more source
New tools for evaluating protein tyrosine sulfation and carbohydrate sulfation [PDF]
, 2018 Sulfation is a common modification of extracelluar glycans and tyrosine residues on proteins, which is important in many signalling pathways and interactions.
Bayliss, R, Yeoh, S
core +1 more source
Molecular cloning, expression, and characterization of novel human SULTIC sulfotransferases that catalyze the sulfonation of N-hydroxy-2- acetylaminofluorene [PDF]
, 1998 Upon sulfonation, carcinogenic hydroxyarylamines such as N-hydroxy-2-acetylaminofluorene (N-OH-2AAF) can be further activated to form ultimate carcinogens in vivo.
Nakayama, Tatsuo +7 more
core +2 more sources
Saccharomyces cerevisiae as a Host for Chondroitin Production
SynBioChondroitin is a glycosaminoglycan that has gained widespread use in nutraceuticals and pharmaceuticals, mainly for treating osteoarthritis. Traditionally, it has been extracted from animal cartilage but recently, biotechnological processes have emerged ...
Márcia R. Couto +3 more
doaj +1 more source
The molecular basis for the broad substrate specificity of human sulfotransferase 1A1. [PDF]
PLoS ONE, 2011 Cytosolic sulfotransferases (SULTs) are mammalian enzymes that detoxify a wide variety of chemicals through the addition of a sulfate group. Despite extensive research, the molecular basis for the broad specificity of SULTs is still not understood. Here,
Ilana Berger +4 more
doaj +1 more source
Genetic risk factors in Finnish patients with Fuchs endothelial corneal dystrophy
Acta Ophthalmologica, EarlyView.Abstract Purpose To study the genetic risk factors of Fuchs endothelial corneal dystrophy (FECD) in the Finnish population using hospital‐based and large biobank cohorts. Methods We genotyped a cohort of 107 Finnish patients with FECD for the primary associated genetic risk factor, the TCF4 (CTG)>50 expansion, and studied their clinical phenotype.
Inka‐Tuulevi Vähämäki +10 more
wiley +1 more source
Tissue-specific expression of cytosolic sulfotransferases in Pristionchus pacificus
, 2023 Sulfation is a ubiquitous biochemical reaction that regulates various cellular and biological events in organisms. It is orchestrated by two classes of enzymes, which either add (sulfotransferases) or remove (sulfatases) a sulfonate group from a large ...
Aloshy, E. +3 more
core
The FEBS Journal, EarlyView.This study reveals that changes in the electrical charge, that is zeta potential of large extracellular vesicles (uEVs) found in urine, can reflect disease progression from diabetes to kidney scarring (fibrosis). With further clinical development, measurement of uEVs charge could provide a simple, noninvasive way to monitor disease progression and help
Melanie Tepuš +6 more
wiley +1 more source
HS sulfotransferases are increased in AD hippocampus.
, 2019 a) The expression of the main HS sulfotransferases responsible of N-, 2-O-, 3-O- and 6-O-sulfation were examined by RTqPCR. Other genes were analyzed including C5-epimerase (GLCE), heparanase (HPSE) and carbohydrate sulfotransferase 8 (CHST8).
Rita Raisman-Vozari (262104) +8 more
core +1 more source