Impaired local hydrophobicity, structural stability and conformational flexibility due to point mutations in SULT1 family of enzymes [PDF]
Journal of the Serbian Chemical Society, 2023 Sulfotransferases (SULTs) are enzymes involved in phase II of the metabolism of xenobiotics. Single nucleotide polymorphisms were identified for genes encoding the SULTs leading to allozymes with modified sulfating activity.
Ceauranu Silvana +2 more
doaj +1 more source
Carbohydrate sulfotransferases: mediators of extracellular communication [PDF]
, 1999 Sulfated carbohydrates mediate diverse extracellular recognition events in both normal and pathological processes. The sulfotransferases that generate specific carbohydrate ‘sulfoforms’ have recently been recognized as key modulators of these processes ...
Bowman, Kendra G, Bertozzi, Carolyn R
core +1 more source
Frontiers in Immunology, 2018 Recent evidence indicates that immune cells contribute to the formation of tumor metastases by regulating the pre-metastatic niche. Whether tumor-derived factors involved in primary tumor formation play a role in metastasis formation is poorly ...
Marta A. Moresco +9 more
doaj +1 more source
Structural and functional characterisation of human sulfotransferases [PDF]
, 1998 The human aryl sulfotransferases HAST4 and HAST4v vary by only two amino acids but exhibit markedly different affinity towards the sulfonate acceptor p-nitrophenol and the sulfonate donor 3'-phosphoadenosine-5'-phosphosulfate (PAPS).
McManus, M. E. +3 more
core +1 more source
The dimerization motif of cytosolic sulfotransferases [PDF]
, 2001 Cytosolic sulfotransferases sulfate steroids such as estrogens and hydroxysteroids. The enzymes, including human estrogen sulfotransferase (hEST) and hydroxysteroid sulfotransferase (hHST), are generally homodimers in solution with mouse estrogen ...
Kenneth B. Tomer +9 more
core +1 more source
Expression of heparan sulfate sulfotransferases in Kluyveromyces lactis and preparation of 3'-phosphoadenosine-5'-phosphosulfate [PDF]
, 2011 Heparan sulfate (HS) belongs to a major class of glycans that perform central physiological functions. Heparin is a specialized form of HS and is a clinically used anticoagulant drug. Heparin is a natural product isolated from pig intestine.
R. Liu +9 more
core +2 more sources
Production and characterization of novel aryl sulfotransferases and their use in bioanalytics [PDF]
, 2023 Polyphenols are the most common natural substances found in food. The largest group is represented by flavonoids, phenolic acids and catechols.
Petránková, Barbora
core +3 more sources
Photoaffinity labeling of human recombinant sulfotransferases with 2-azidoadenosine 3′,5′-[5′-32P]bisphosphate [PDF]
, 1996 Photoaffinity labeling with 2-azidoadenosine 3′,5′-[5′-P]bisphosphate was used to identify and characterize adenosine 3′,5′-bisphosphate-binding proteins in human liver cytosol and recombinant sulfotransferase proteins. The sulfotransferases investigated
Veronese, Maurice E. +8 more
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Angewandte Chemie, EarlyView.A glycan having a hydrazide tag enables chemoenzymatic synthesis of HS oligosaccharides. The hydrazide can, under mild acidic conditions, react with an aldehyde‐containing resin to give an immobilized hydrazone that is stable under neutral conditions, allowing washing. The product can be released by transiminolysis using aqueous hydroxylamine to give a
Francesco Palmieri +4 more
wiley +2 more sources
The role of heparan sulfate maturation in cancer: A focus on the 3O-sulfation and the enigmatic 3O-sulfotransferases (HS3STs) [PDF]
, 2019 peer reviewedHeparansulfate (HS) modifications are master regulators of the cross-talk between cell and matrix and modulate the biological activity of an array of HS binding proteins, including growth factors and chemokines, morphogens and immunity cell ...
Gulberti, Sandrine +3 more
core +1 more source