Results 31 to 40 of about 7,639 (223)
Frontiers in Immunology, 2018 Recent evidence indicates that immune cells contribute to the formation of tumor metastases by regulating the pre-metastatic niche. Whether tumor-derived factors involved in primary tumor formation play a role in metastasis formation is poorly ...
Marta A. Moresco +9 more
doaj +1 more source
Steroid Sulfation in Neurodegenerative Diseases
Frontiers in Molecular Biosciences, 2022 Steroid sulfation and desulfation participates in the regulation of steroid bioactivity, metabolism and transport. The authors focused on sulfation and desulfation balance in three neurodegenerative diseases: Alzheimer´s disease (AD), Parkinson´s disease
Jana Vitku +4 more
doaj +1 more source
Impaired local hydrophobicity, structural stability and conformational flexibility due to point mutations in SULT1 family of enzymes [PDF]
Journal of the Serbian Chemical Society, 2023 Sulfotransferases (SULTs) are enzymes involved in phase II of the metabolism of xenobiotics. Single nucleotide polymorphisms were identified for genes encoding the SULTs leading to allozymes with modified sulfating activity.
Ceauranu Silvana +2 more
doaj +1 more source
Expression of heparan sulfate sulfotransferases in Kluyveromyces lactis and preparation of 3'-phosphoadenosine-5'-phosphosulfate [PDF]
, 2011 Heparan sulfate (HS) belongs to a major class of glycans that perform central physiological functions. Heparin is a specialized form of HS and is a clinically used anticoagulant drug. Heparin is a natural product isolated from pig intestine.
R. Liu +9 more
core +1 more source
Sulfuryl group transfer from coelenterazine sulfate to PAP by other sulfotransferases.
, 2022 We surveyed four sulfotransferases (STs) for their ability to transfer the sulfate from coelenterazine sulfate to PAP producing coelenterazine. The mouse estrogen ST was chosen based on sequence similarity (Fig 9) to the Coel-ST and the others based on ...
Ira Schildkraut (29742) +7 more
core +1 more source
Similar Enzymatic Functions in Distinct Bioluminescence Systems: Evolutionary Recruitment of Sulfotransferases in Ostracod Light Organs [PDF]
<p>Genes from ancient families are sometimes involved in the convergent evolutionary origins of similar traits, even across vast phylogenetic distances. Sulfotransferases are an ancient family of enzymes that transfer sulfate from a donor to a wide
Lau, Emily
core +2 more sources
Angewandte Chemie, EarlyView.A chemoenzymatic methodology is described that provided a panel of 6‐sulfo sialyl Lewisx‐containing glycans that were probed for receptor specificity of MERS‐CoV. Although the fucoside of 6‐sulfo‐SLex does not directly interact with the spike, it pre‐organizes the molecule into a conformation to allow a salt bridge between the sulfate and the ...
Yunfei Wu +7 more
wiley +2 more sources
Sugar glues for broken neurons
Biomolecular Concepts, 2013 Proteoglycans (PGs) regulate diverse functions in the central nervous system (CNS) by interacting with a number of growth factors, matrix proteins, and cell surface molecules.
Swarup Vimal P. +3 more
doaj +1 more source
Polysaccharide sulfotransferases: the identification of putative sequences and respective functional characterisation. [PDF]
Essays BiochemThe vast structural diversity of sulfated polysaccharides demands an equally diverse array of enzymes known as polysaccharide sulfotransferases (PSTs). PSTs are present across all kingdoms of life, including algae, fungi and archaea, and their sulfation ...
Mistry R +5 more
europepmc +2 more sources
Journal of International Medical Research, 2023 Adverse drug reactions represent a major health burden because they cause notable patient morbidity and mortality. From this viewpoint, several strategies have been developed to prevent or reduce adverse drug reactions.
Romany H. Thabet +5 more
doaj +1 more source