Results 101 to 110 of about 50,577 (283)

Synthesis and Characterization of Sulfonamide-Containing Naphthalimides as Fluorescent Probes

Molecules
A tumor-targeting fluorescent probe has attracted increasing interest in fluorescent imaging for the noninvasive detection of cancers in recent years. Sulfonamide-containing naphthalimide derivatives (SN-2NI, SD-NI) were synthesized by the incorporation ...
Zhi-Wei Liu, Fan Liu, Chun-Tao Shao, Guo-Ping Yan, Jiang-Yu Wu   +4 more
doaj   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Well‐Defined Nickel Precatalysts: Form, Function, and Application

Chemistry – A European Journal, EarlyView.
This review provides guidance on which nickel precatalysts to choose for a given application or which properties to prioritize in reaction development. A summary of the ease of synthesis, stability, diversity, accessibility, modularity, and general applicability is provided along with a related infographic.
Morgan E. John, George A. Koutsantonis, Reto Dorta, Scott G. Stewart   +3 more
wiley   +1 more source

Evaluation of antibacterial, cytotoxicity, and apoptosis activity of novel chromene-sulfonamide hybrids synthesized under solvent-free conditions and 3D-QSAR modeling studies

Scientific Reports
In this study, eleven novel chromene sulfonamide hybrids were synthesized by a convenient method in accordance with green chemistry. At first, chromene derivatives (1–9a) were prepared through the multi-component reaction between aryl aldehydes ...
Shakila Ghomashi, Reihane Ghomashi, Mohammad Sadegh Damavandi, Zeynab Fakhar, Seyedeh Yasaman Mousavi, Azhar Salari-Jazi, Sajjad Gharaghani, Ahmad Reza Massah   +7 more
doaj   +1 more source

Design, Synthesis, Biological Evaluation and Docking, ADME Studies of Novel Phenylsulfonyl Piperazine Analogues as α-Amylase Inhibitors

Cumhuriyet Science Journal
Diabetes mellitus (DM) stands as one of the most widespread diseases encountered today. It is primarily characterized by diminished insulin levels and heightened blood glucose concentrations. Inhibition of the α-amylase enzyme plays a pivotal role in the
Kerem Buran
doaj   +1 more source

Synthesis of Chiral‐at‐Sulfur(VI) Sulfonimidamide Brønsted Acids

Chemistry – A European Journal, EarlyView.
A simple, modular route to chiral‐at‐sulfur(VI) Brønsted acids is described, delivering S‐chiral sulfonimidamides, C2‐symmetric acids, and BINOL‐based hybrid systems through stereospecific reactions of sulfonimidoyl fluorides and chlorides. ABSTRACT Herein, we report an efficient and simple strategy to access diverse chiral‐at‐sulfur(VI) Brønsted acids.
Yu Han, Natassa Lional, Dieuwertje E. Streefkerk, Jesse M. S. Goed, Bo Chen, Han Zuilhof, Fedor M. Miloserdov   +6 more
wiley   +1 more source

Design, Synthesis, and Evaluation of EA-Sulfonamides and Indazole-Sulfonamides as Promising Anticancer Agents: Molecular Docking, ADME Prediction, and Molecular Dynamics Simulations

Chemistry
New EA-sulfonamides and indazole-sulfonamides were synthesized, characterized, and evaluated for their anticancer activities. The target compound structures were elucidated using various spectroscopic techniques such as NMR-{1H and 13C}, infrared ...
Nassima Saghdani, Nabil El Brahmi, Abdelmoula El Abbouchi, Rachid Haloui, Souad Elkhattabi, Gérald Guillaumet, Saïd El Kazzouli   +6 more
doaj   +1 more source

Designing Threefold π‐Surfaces Through Peripheral Halogenation to Shape Multidirectional Molecular Packing

Chemistry – A European Journal, EarlyView.
The complete series of hexahalogenated triptycene‐tribenzoquinones, comprising newly synthesized fluoro‐, bromo‐, and iodo‐substituted derivatives together with the previously reported chloro analogue, enables systematic comparison of their molecular properties and intermolecular interactions in relation to their crystal packing modes.
Shuta Tsuruga, Kenzo Suzuki, Hiromichi Yokoyama, Yoshiaki Shoji, Takanori Fukushima   +4 more
wiley   +1 more source

Synthesis, biological investigation, and in silico studies of 2-aminothiazole sulfonamide derivatives as potential antioxidants

EXCLI Journal : Experimental and Clinical Sciences
Antioxidant compounds have gained current interest as potential protective agents for several therapeutic applications. Antimicrobial drug resistance and infectious diseases also still be concerning globally health issues.
Apilak Worachartcheewan, Ratchanok Pingaew, Veda Prachayasittikul, Setthawut Apiraksattayakul, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul   +6 more
doaj   +1 more source

Sulfonamide in agricultural pest management: past and recent prospects

The sulfonamide moiety (–SO 2 NH–) is a structurally versatile motif in agrochemical discovery. It can engage in hydrogen bonding, modulate molecular polarity and acidity, and act as a bioisostere or linking ...
Jian Wu, Shengxin Guo, Wei Sun, WenYi Li, Anjing Liao, Han Yan   +5 more
core   +1 more source