Results 131 to 140 of about 50,577 (283)

Molecular Glue Degraders in Early Development for Cancer Therapy

Medicinal Research Reviews, EarlyView.
ABSTRACT Molecular glue degraders are an emerging class of small molecule allosteric modulators that induce or stabilize protein‐protein interactions, enabling targeted degradation of previously intractable proteins. By redirecting E3 ligases to recognize neosubstrates, proteins that are not typically recognized by a specific E3 ubiquitin ligase, they ...
E. Sila Ozdemir, Hyunbum Jang, Ozlem Keskin, Attila Gursoy, Ruth Nussinov   +4 more
wiley   +1 more source

Synthesis of 1,2,4-Oxadiazole Sulfonamide Derivatives and Their Biological Investigation as Monoamine Oxidase Inhibitors. [PDF]

Molecules
Shetnev AA, Gasilina OA, Baykov SV, Turmanov R, Appazov N, Zhapparbergenov R, Togyzbayeva N, Korsakov MK, Cloete SJ, Petzer A, Petzer JP.   +10 more
europepmc   +1 more source

ISAba1‐mediated crp‐osmC amplification enhances host‐associated fitness in Acinetobacter baumannii

mLife, EarlyView.
Abstract Acinetobacter baumannii is a pathogen, highly adaptable to both hospital‐ and host‐associated environments. Understanding the genetic mechanisms underlying its adaptability is critical for controlling its persistence. Our study identified the crp‐osmC gene cluster, flanked by ISAba1 elements, as a significant genetic structure undergoing ...
Da‐Wei Wei, Jiangqing Huang, Hailing Fang, Xinyu Wang, Gang Zhang, Chao Wang, Yuqin Song, Jie Feng   +7 more
wiley   +1 more source

Correction: Wang et al. Research Progress and Prospects of Modified Biochar in the Adsorption and Degradation of Sulfonamide Antibiotics. <i>Antibiotics</i> 2026, <i>15</i>, 268. [PDF]

Antibiotics (Basel)
Wang J, Hou Y, Li X, Zhao R, Mu X, Liu Y, Huang C, Fu F, Yang F.   +8 more
europepmc   +1 more source

Structural and Biochemical Characterization of the Diaminopimelate Epimerase DapF From Pseudomonas aeruginosa PA14

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The emergence of antibiotic resistance in bacteria is a major threat to global public health. To combat increasingly drug‐resistant bacteria like Pseudomonas aeruginosa, new targets for pharmaceuticals need to be explored. One such potential target for P.
Philipp Schneider, Claudia Hanko, Konrad Büssow, Stefan Schmelz, Wulf Blankenfeldt   +4 more
wiley   +1 more source

Sulfonamides Inhibit Root Growth via ROS-Triggered and MPK3/6-Modulated Synthesis of the Ethylene Precursor ACC. [PDF]

Biology (Basel)
He T, Zhao Z, Liu X, Chang H, Du Z, Zhu L, Feng G.   +6 more
europepmc   +1 more source

Revisiting small‐molecule fluorescent probes in food freshness detection

Smart Molecules, EarlyView.
Fluorescent probes serve as versatile tools for food freshness monitoring. This review summarizes recent advances in probes targeting biogenic amines, hydrogen sulfide, pH values, and other key spoilage markers, highlighting their design principles, sensing mechanisms, and practical applications in food quality monitoring. Abstract Food spoilage driven
Xinrui Wang, Zhao Wang, Jingwen Zou, Xuyuan Jiang, Changyu Bian, Zhiqiang Mao   +5 more
wiley   +1 more source

Inhibition and Molecular Recognition of Lactoperoxidase by Acetohydrazide-Based Sulfonamide Derivatives. [PDF]

J Mol Recognit
Gökçe B, Arslan G, Muhammed MT, Albayrak Ö.   +3 more
europepmc   +1 more source

Advances in Unconventional and Sustainable Synthetic Approaches to Benzopyran Scaffolds

The Chemical Record, EarlyView.
This review provides a comprehensive and critical analysis of low‐impact synthetic methodologies reported in the last 8 years (2018–2026) for the construction of benzopyran‐derived scaffolds, such as coumarins, flavones, chromones, chromenes, and chromanes. The benzopyran scaffold is a versatile family of heterocycles found in a wide range of bioactive
Nathalia B. Sá, Patrick C. Nobre, Isabelly O. Ferreira, Juliano B. Azeredo, Vanessa Nascimento   +4 more
wiley   +1 more source

Interactions between sulfonamide antibiotics and metal ions: does toxicity increase or decrease? [PDF]

RSC Adv
Cui F, Cao S, Zhu Y, Li H, Guo G, Jiang J, Bing X, Ge L.   +7 more
europepmc   +1 more source