Results 1 to 10 of about 38,968 (186)

Revealing the role of increased SK3 expression in sulfonylurea resistance triggered by prolonged exposure [PDF]

Nutrition & Diabetes
Background Sulfonylureas have long been utilized in the management of type-2 diabetes mellitus (T2DM) due to their insulin-secretagogue properties. However, their clinical efficacy is hindered by the risk of severe hypoglycemia and secondary sulfonylurea
Jung Gyu Park, Minseok Kim, Sungje Yoo, Sun Wook Hwang, Jongsoo Mok, Joonghoon Park, Keon Wook Kang   +6 more
doaj   +2 more sources

Long-Term Seizure and Neurodevelopmental Outcomes of Three Children with Developmental Delay, Epilepsy, and Neonatal Diabetes (DEND) Syndrome after Early Initiation of Sulphonylurea [PDF]

Annals of Indian Academy of Neurology
Developmental delay, epilepsy, and neonatal diabetes (DEND) syndrome, caused by de novo mutations in ABCC8/KCNJ11 genes encoding Adenosine Triphosphate (ATP)-sensitive potassium channels, is an unusual cause of infantile-onset developmental/epileptic ...
Neena Baby, Kollencheri P Vinayan, Praveen Pavithran, Kshitij Bansal, Nisha Bhavani, Yatheesha B Lokeshappa, Arun G Roy   +6 more
doaj   +2 more sources

Sulfonylurea Is Associated With Higher Risks of Ventricular Arrhythmia or Sudden Cardiac Death Compared With Metformin: A Population‐Based Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Commonly prescribed diabetic medications such as metformin and sulfonylurea may be associated with different arrhythmogenic risks. This study compared the risk of ventricular arrhythmia or sudden cardiac death between metformin and ...
Teddy Tai Loy Lee, Jeremy Man Ho Hui, Yan Hiu Athena Lee, Danish Iltaf Satti, Yuki Ka Ling Shum, Pias Tang Hoi Kiu, Abraham Ka Chung Wai, Tong Liu, Wing Tak Wong, Jeffrey Shi Kai Chan, Bernard Man Yung Cheung, Ian Chi Kei Wong, Shuk Han Cheng, Gary Tse   +13 more
doaj   +1 more source

Clinical features and sulfonylurea usage among outpatients with diabetes aged ≥90 years in an urban diabetes clinic in Tokyo

Journal of Diabetes Investigation, 2022
Aims/Introduction Aging of society is accelerating in many countries. The purpose of this study was to describe the clinical features and sulfonylurea usage among diabetes outpatients aged ≥90 years (nonagenarians). Materials and Methods This study was a
Toshiko Kobori, Yukiko Onishi, Yoko Yoshida, Tazu Tahara, Takako Kikuchi, Tetsuya Kubota, Masahiko Iwamoto, Shoko Hamano, Masato Kasuga   +8 more
doaj   +1 more source

Successful switching from insulin to sulfonylurea in a 3-month-old infant with diabetes due to p.G53D mutation in [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2018
Permanent neonatal diabetes mellitus is most commonly caused by mutations in the ATP-sensitive potassium channel (KATP) subunits. Prompt initiation of sulfonylurea treatment can improve glycemic control in children with KCNJ11 mutation.
Jong Seo Yoon, Kyu Jung Park, Young Bae Sohn, Hae Sang Lee, Jin Soon Hwang   +4 more
doaj   +1 more source

Hospitalization for Heart Failure Among Patients With Diabetes Mellitus and Reduced Kidney Function Treated With Metformin Versus Sulfonylureas: A Retrospective Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Metformin and sulfonylurea are commonly prescribed oral medications for type 2 diabetes mellitus. The association of metformin and sulfonylureas on heart failure outcomes in patients with reduced estimated glomerular filtration rate remains ...
Tadarro L. Richardson, Amber J. Hackstadt, Adriana M. Hung, Robert A. Greevy, Carlos G. Grijalva, Marie R. Griffin, Tom A. Elasy, Christianne L. Roumie   +7 more
doaj   +1 more source

Reduction of Sulfonylurea with the Initiation of Basal Insulin in Patients with Inadequately Controlled Type 2 Diabetes Mellitus Undergoing Long-Term Sulfonylurea-Based Treatment [PDF]

Diabetes & Metabolism Journal, 2016
BackgroundThere were a limited number of studies about β-cell function after insulin initiation in patients exposed to long durations of sulfonylurea treatment.
Yeoree Yang, Jeong-Ah Shin, Hae Kyung Yang, Seung-Hwan Lee, Seung-Hyun Ko, Yu-Bae Ahn, Kun-Ho Yoon, Jae-Hyoung Cho   +7 more
doaj   +1 more source

Sulfonylurea and Cancer Risk Among Patients With Type 2 Diabetes: A Population-Based Cohort Study

Frontiers in Endocrinology, 2022
BackgroundCurrent evidence of the association between the use of sulfonylurea and cancer risk is highly conflicting and little evidence of this association is from the mainland Chinese population.
Houyu Zhao, Zhike Liu, Lin Zhuo, Peng Shen, Hongbo Lin, Yexiang Sun, Siyan Zhan, Siyan Zhan, Siyan Zhan   +8 more
doaj   +1 more source

Erectile Dysfunction and Low Sex Drive in Men with Type 2 DM: The Potential Role of Diabetic Pharmacotherapy [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Diabetic men with erectile dysfunction have not been widely studied. They have low testosterone levels, causing low sex drive and erectile dysfunction.
Hayder M. Al-Kuraishy, Ali I. Al-Gareeb
doaj   +1 more source

Identification SNP rs5219 KCNJ11 gene and blood glucose levels in type 2 diabetes mellitus patients at Moewardi Hospital Surakarta [PDF]

Pharmaciana, 2021
Diabetes Mellitus (DM) is a metabolic disease that developed due to the pancreas does not sufficient to produce insulin or the body cannot effectively use the insulin it produces.
Nur Aida, Rita Maliza, Imaniar Noor Faridah, Melinda Widianingrum, Dyah Aryani Perwitasari   +4 more
doaj   +1 more source