Results 151 to 160 of about 74,360 (259)

Click Chemistry‐Enabled Synthesis of Diversely Functionalized Cyclobutenes

open access: yesAsian Journal of Organic Chemistry, EarlyView.
This work expands the synthetic scope of a [2 + 2] click chemistry cycloaddition between ethene‐1,1‐disulfonyl fluoride (EDSF) and a diverse library of alkynes to access 29 highly functionalized cyclobutenes. Substrate variation, including electron‐withdrawing and electron‐donating groups, enables precise regiocontrol.
Christopher J. Smedley
wiley   +1 more source

Discovery and characterization of a novel family of prokaryotic nanocompartments involved in sulfur metabolism. [PDF]

open access: yesElife, 2021
Nichols RJ   +8 more
europepmc   +1 more source

Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies

open access: yesAnnals of Neurology, EarlyView.
Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical, and genetic disease mechanisms with a resulting emphasis on ...
Brent L. Fogel   +10 more
wiley   +1 more source

The Spectrum of Neurologic Phenotypes Associated With NUS1 Pathogenic Variants: A Comprehensive Case Series

open access: yesAnnals of Neurology, EarlyView.
Objective A growing body of evidence indicates a strong genetic overlap between developmental and epileptic encephalopathies (DEEs) and movement disorders. De novo loss‐of‐function variants in NUS1 have been recently identified in DEE cases. Herein, we report a large cohort of cases with pathogenic NUS1 variants and describe their clinical presentation
Sarah M. Brooker   +79 more
wiley   +1 more source

Microbe-induced coordination of plant iron-sulfur metabolism enhances high-light-stress tolerance of Arabidopsis. [PDF]

open access: yesPlant Commun
Shekhawat K   +11 more
europepmc   +1 more source

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