Results 131 to 140 of about 5,755 (182)
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Antioxidants Countermeasures Against Sulfur Mustard
Mini-Reviews in Medicinal Chemistry, 2012Sulfur mustard (SM) is a vesicant chemical warfare agent that persists as a serious menace from the viewpoint of acute and chronic toxicity, simple synthesis and no effective treatment currently being available. The two most deleterious basic molecular mechanisms in SM poisoning are: inflammation and over-activation of poly(ADP-ribose) polymerase and ...
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Accidental sulfur mustard exposure: A case report
Toxicology Letters, 2018The clinical progression following a sulfur mustard-induced skin exposure is well documented in the literature. Upon skin contact and a characteristic latency period, sulfur mustard (SM) causes erythema, blister formation and ulceration, which is associated with wound healing disorders that may require surgical treatment. Here, we present a case report
Annette, Schmidt +4 more
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Phenyl sulfur mustard derivatives of distamycin A
Bioorganic & Medicinal Chemistry Letters, 2000The design, synthesis, and cytotoxic activity of novel benzoyl and cinnamoyl sulfur mustard derivatives of distamycin A are described and structure activity relationships are discussed. These sulfur mustards are more potent cytotoxics than corresponding nitrogen mustards in spite of the lower alkylating power, while their sulfoxide analogues are ...
P. Cozzi +6 more
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Other considerations about carcinogenicity of sulfur mustard
Cancer Causes & Control, 2013Dear Editor in Chief,We read with great interest a recently published article byZafarghandi et al. [1] in Cancer Cause and Control journal.In this long-term follow-up cohort study, the incidence ofcancer in Iranian sulfur mustard (SM)-exposed veteranswas assessed and reported in comparison with a matchedcontrol group.
Reza, Karbasi-Afshar +2 more
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The chronic effects of sulfur mustard exposure
Toxicology, 2009Whilst the acute effects of sulfur mustard have been relatively well characterised, the chronic effects of short term but significant exposures are still evolving. The approximately 30,000 Iranian victims of CW exposure from the 1980 to 1988 Iran-Iraq war who are currently being followed form a key population who are now 20 years post-exposure. The key
Mike, Rowell +3 more
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Shapes of Sulfur, Oxygen, and Nitrogen Mustards
The Journal of Physical Chemistry A, 2011Thorough conformational analyses have been performed on representative sulfur, oxygen, and nitrogen mustards. A total of 23, 18, and 38 unique conformers have been located for SM, OM, and NM, respectively, at the MP2/aug-cc-pVDZ level of theory. Despite the fact that these molecules differ only in the identity of the central heteroatom, comparison of ...
Janos, Nadas +2 more
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Effect of sulfur mustard on murine lymphocytes
Toxicology Letters, 1991The effect on spleen cells of a single in vivo treatment with sulfur mustard was analyzed in mice 1 week after intoxication. A marked decrease in the number of total spleen cells was observed in mice receiving high doses of sulfur mustard. Flow cytometric analysis indicated that B-lymphocytes were relatively more affected than T-lymphocytes by this ...
J P, Coutelier +3 more
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Medical management of cutaneous sulfur mustard injuries
Toxicology, 2009Sulfur mustard (2,2'-dichlorodiethyl sulfide; HD) is a potent vesicating chemical warfare agent that poses a continuing threat to both military and civilian populations. Significant cutaneous HD injuries can take several months to heal, necessitate lengthy hospitalizations, and result in long-term complications.
John S, Graham +6 more
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Toxicodynamics of sulfur mustard.
International journal of clinical pharmacology, therapy, and toxicology, 1989Mustards have become an important topic of global discussion in recent years. The latest extensive reports and conference of 145 nations in Paris (January 13, 1989) reveal that several countries have stockpiled large quantities of mustard gas. This situation creates an imminent danger to accidental or intentional exposure of this gas to civil ...
S M, Somani, S R, Babu
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Sulfur mustard-induced poikiloderma: A case report
Cutaneous and Ocular Toxicology, 2010Sulfur mustard (SM) is a potent chemical warfare agent that was widely used during the First World War and the Iran-Iraq conflict. This vesicant agent causes several acute and chronic effects on the skin, eye, and respiratory system. We report the case of a 41-year-old man who was injured with SM in Iraq chemical attack in 1988.
Seyed Naser, Emadi +6 more
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