Results 101 to 110 of about 1,800,802 (268)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Alactic base excess as an early predictor of sepsis-associated acute kidney injury: a prospective observational study

European Journal of Medical Research
Background Sepsis-associated acute kidney injury (SA–AKI) is a major contributor to morbidity and mortality in critically ill patients. Early detection and intervention are essential for improving clinical outcomes. This study investigates the predictive
Tatikonda Chandra Mouli, Sanghamitra Mishra, Samir Samal, Satyajit Choudhury, Pritam Chhotray, Sagarika Panda, Shakti Bedanta Mishra   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Childhood Hodgkin Lymphoma (hl): single centre experience from eastern India

Pediatric Hematology Oncology Journal, 2022
ADITI SHARMA, SAROJ PANDA, NIRMALYA PRADHAN, MRUTYUNJAY DASH   +3 more
doaj   +1 more source

Concurrent splenic and renal infarction in scrub typhus: expanding the vasculitic spectrum

BMC Infectious Diseases
Background Scrub typhus is a mite-borne zoonotic infection caused by Orientia tsutsugamushi, characterized by systemic vasculitis and multiorgan involvement.
Yallawar Nipun Narayan, Sagarika Panda, Biswajit Nayak, Kalpana Majhi, Shakti Bedanta Mishra   +4 more
doaj   +1 more source

Lump Sum versus Annuity: Choices of Kentucky Farmers during the Tobacco Buyout Program

Our study uses the data collected during the implementation of the tobacco buyout program in Kentucky to evaluate how rural households, diverse in income, age, family structure, location, education level, and other characteristics, made a choice between ...
Marshall, Maria I., Pushkarskaya, Helen N.   +1 more
core  

SUM Project Results Review

, 2012
This document is the “Project Results Review” report of the Surveillance in an Urban environment using Mobile sensors Project, corresponding to the Contract A-0827-RT-GC [AD.
Rudolf, Daniel, Dill, Stephan, SUM, Consortium, Peichl, Markus   +3 more
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diagnostic and therapeutic challenges into snakebite-induced thrombotic microangiopathy: a case report and review of the literature

Journal of Medical Case Reports
Background Snakebite envenomation is a significant global health issue, with India accounting for a substantial number of cases, particularly in rural areas.
Sagarika Panda, Kalpana Majhi, Tapan Biswas, Shakti Bedanta Mishra   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source