Results 71 to 80 of about 129,441 (306)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Propagating waves in polar coronal holes as seen by SUMER and EIS

, 2009
To study the dynamics of coronal holes and the role of waves in the acceleration of the solar wind, spectral observations were performed over polar coronal hole regions with the SUMER spectrometer on SoHO and the EIS spectrometer on Hinode.
Banerjee, Banerjee, Banerjee, Culhane, D. Banerjee, Deforest, G. R. Gupta, G. Stenborg, Kosugi, L. Teriaca, O'Shea, O'Shea, O'Shea, Ofman, Ofman, Ofman, Ofman, Popescu, S. Imada, S. K. Solanki, Torrence, Wilhelm   +21 more
core   +1 more source

Doppler shift of hot coronal lines in a moss area of an active region [PDF]

, 2012
The moss is the area at the footpoint of the hot (3 to 5 MK) loops forming the core of the active region where emission is believed to result from the heat flux conducted down to the transition region from the hot loops. Studying the variation of Doppler
Dadashi, Neda, Solanki, Sami K., Teriaca, Luca, Tripathi, Durgesh, Wiegelmann, Thomas   +4 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Organic Food Quality: Can it exist without Measurement? [PDF]

, 2006
- Consumers who purchase organic foods are motivated primarily by the health benefits. What assurances are there that defining organic products based on inputs, methods, and ingredients will meet or exceed consumer expectations if there are no re ...
Ismond, Alan
core  

Stereoscopic Polar Plume Reconstructions from Stereo/Secchi Images

, 2009
We present stereoscopic reconstructions of the location and inclination of polar plumes of two data sets based on the two simultaneously recorded images taken by the EUVI telescopes in the SECCHI instrument package onboard the \emph{STEREO (Solar ...
Aschwanden, Aschwanden, Aschwanden, B. Inhester, B. Podlipnik, Banaszkiewicz, DeForest, DeForest, Feng, Fisher, Fowler, Gabriel, Gabriel, Habbal, Inhester, J. P. Wuelser, K. Wilhelm, L. Feng, Neukirch, Patsourakos, R. A. Howard, Raouafi, Raouafi, S. K. Solanki, S. P. Plunkett, Saito, T. Wiegelmann, W. Q. Gan, Wang, Wilhelm, Wilhelm, Wilhelm, Wuelser   +32 more
core   +1 more source

The Structure and Dynamics of the Upper Chromosphere and Lower Transition Region as Revealed by the Subarcsecond VAULT Observations [PDF]

, 2009
The Very high Angular resolution ULtraviolet Telescope (VAULT) is a sounding rocket payload built to study the crucial interface between the solar chromosphere and the corona by observing the strongest line in the solar spectrum, the Ly-a line at 1216 ...
A. Vourlidas, A. Vourlidas, A.G. Wijn de, A.M. Title, A.O. Benz, B. de Pontieu, B. Pontieu de, B. Pontieu de, B. Pontieu De, B. Sanchez Andrade-Nuño, C. Emerich, C. M. Korendyke, C.J. Schrijver, C.J. Schrijver, C.M. Korendyke, D. Berghmans, D.E. Innes, D.K. Prinz, D.K. Prinz, E. Landi, E. Landi, F. Budnik, G. Stenborg, G. Tsiropoula, H. Peter, I. Nestoras, J. Fontenla, J. Koza, J. Trujillo Bueno, J.D. Purcell, J.D.F. Bartoe, J.E. Vernazza, J.F. Dowdy Jr., J.M. Fontenla, K. Wilhelm, K. Wilhelm, K.G. Puschmann, L. Ofman, L. Teriaca, L.D. Xia, P. Gouttebroze, P. Gouttebroze, P. Judge, P. Judge, R.J. Rutten, R.M. Bonnet, R.M. Bonnet, S. Krucker, S. Patsourakos, S. Patsourakos, S.C. Miller Jr., S.K. Antiochos, T.J. Okamoto, T.N. Woods, U. Feldman, U. Feldman, U. Feldman, U. Feldman, U. Schühle, W. Curdt, Y. Lin, Ø. Langangen   +61 more
core   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Ubiquitous High Speed Transition Region and Coronal Upflows in the Quiet Sun

, 2009
We study the line profiles of a range of transition region (TR) emission lines observed in typical quiet Sun regions. In magnetic network regions, the Si IV 1402\AA{}, C IV 1548\AA{}, N V 1238\AA{}, O VI 1031\AA{}, and Ne VIII 770\AA{} spectral lines ...
Bart De Pontieu, Beckers, Chae, Davey, De Pontieu, De Pontieu, De Pontieu, Fleck, Hansteen, Hara, Judge, Judge, Martínez-Sykora, McIntosh, McIntosh, McIntosh, Peter, Priest, Rouppe van der Voort, Schrijver, Scott W. McIntosh, Secchi, Tian, Tomczyk   +23 more
core   +1 more source

Observations Supporting the Role of Magnetoconvection in Energy Supply to the Quiescent Solar Atmosphere [PDF]

, 2006
Identifying the two physical mechanisms behind the production and sustenance of the quiescent solar corona and solar wind poses two of the outstanding problems in solar physics today.
Armstrong, James D., Curdt, Werner, Davey, Alisdair R., Hassler, Donald M., Lin, Gang, McIntosh, Scott W., Wilhelm, Klaus   +6 more
core   +3 more sources