Results 51 to 60 of about 8,548 (279)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Renormalon disappearance in Borel sum of the 1/N expansion of the Gross-Neveu model mass gap

, 2003
The exact mass gap of the O(N) Gross-Neveu model is known, for arbitrary $N$, from non-perturbative methods. However, a "naive" perturbative expansion of the pole mass exhibits an infinite set of infrared renormalons at order 1/N, formally similar to the
A.B. Zamolodchikov, C. Arvanitis, Damien Reynaud, F. David, Jean-Loic Kneur, M. Campostrini, P. Forgacs   +6 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Generalized nörlund method and convergence acceleration

Mathematical Modelling and Analysis, 2007
Some propositions on λ‐boundedness for generalized Nörlund method of summability (N, Pn ), where Pn are bounded linear operators from Banach space X into X, are proved. Using these results we have verified some propositions on convergence acceleration by 
Olga Meronen, Ivar Tammeraid
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

( H p − L p ) $(H_{p}-L_{p})$ -Type inequalities for subsequences of Nörlund means of Walsh–Fourier series

Journal of Inequalities and Applications, 2023
We investigate the subsequence { t 2 n f } $\{t_{2^{n}}f \}$ of Nörlund means with respect to the Walsh system generated by nonincreasing and convex sequences.
David Baramidze, Lars-Erik Persson, Kristoffer Tangrand, George Tephnadze   +3 more
doaj   +1 more source

Distributional Borel Summability for Vacuum Polarization by an External Electric Field

, 2002
It is proved that the divergent perturbation expansion for the vacuum polarization by an external constant electric field in the pair production sector is Borel summable in the distributional sense.Comment: 14 ...
Caliceti E., Caliceti E., Caliceti E., Caliceti E., Emanuela Caliceti, Graffi S., Jentschura U. O., Ogievetski V.   +7 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Formalization of Complex Vectors in Higher-Order Logic

, 2014
Complex vector analysis is widely used to analyze continuous systems in many disciplines, including physics and engineering. In this paper, we present a higher-order-logic formalization of the complex vector space to facilitate conducting this analysis ...
H. Herencia-Zapana, J. Harrison, J. Harrison, K. Scharnhorst, M.Y. Mahmoud   +4 more
core   +1 more source