Results 51 to 60 of about 58,299 (310)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Particle Propagation on a Circle with a Point Interaction

, 2009
We study a particle propagation on a circle in the presence of a point interaction. We show that the one-particle Feynman kernel can be written into the sum of reflected and transmitted trajectories which are weighted by the elements of the n-th power of
Asorey M, Chadan K, Chaichian M, Gorbachuk V I, Griffiths D J, Makoto Sakamoto, Reed M, Satoshi Ohya, Schulman L S   +8 more
core   +1 more source

A Generalized Poisson Summation Formula

Applied and Computational Harmonic Analysis, 1996
The authors give two proofs for a generalization of the Poisson formula \(\sum_{n\in Z} f(n) = \sum_{n\in Z} \widehat f(n)\). Although the generalization involves abelian groups only, the original proofs went by the way of the Heisenberg group and its discrete subgroups.
Auslander, Louis, Meyer, Yves
openaire   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Effect of local plastic component on crack opening displacement and on J-integral of a circumferential penetrated crack

Mechanical Engineering Journal, 2020
This paper describes the effect of local plastic component on J-integral and crack opening displacement (COD) evaluation of a circumferential penetrated crack, applicable to the leak before break (LBB) assessment for sodium cooled fast reactor (SFR ...
Hideo MACHIDA, Manabu ARAKAWA, Takashi WAKAI   +2 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Bisection Series Approach for Exotic ₃F₂(1)-Series

Mathematics
By employing the bisection series approach, two classes of nonterminating 3F2(1)-series are examined. Several new summation formulae are established in closed form through the summation formulae of Gauss and Kummer for the 2F1(±1)-series.
Marta Na Chen, Wenchang Chu
doaj   +1 more source

A Meshfree Approach for Solving Fractional Galilei Invariant Advection–Diffusion Equation through Weighted–Shifted Grünwald Operator

Mathematics, 2022
Fractional Galilei invariant advection–diffusion (GIADE) equation, along with its more general version that is the GIADE equation with nonlinear source term, is discretized by coupling weighted and shifted Grünwald difference approximation formulae and ...
Farzaneh Safari, Qingshan Tong, Zhen Tang, Jun Lu   +3 more
doaj   +1 more source

Finite temperature density matrix and two-point correlations in the antiferromagnetic XXZ chain

, 2005
We derive finite temperature versions of integral formulae for the two-point correlation functions in the antiferromagnetic XXZ chain. The derivation is based on the summation of density matrix elements characterizing a finite chain segment of length $m$.
Alexander Seel, Boos H E, Boos H E, Boos H E, Boos H E, Boos H Jimbo M Miwa T Smirnov F Takeyama Y, Boos H Jimbo M Miwa T Smirnov F Takeyama Y, Boos H Jimbo M Miwa T Smirnov F Takeyama Y, Boos H Jimbo M Miwa T Smirnov F Takeyama Y, Essler F H L, Frank Göhmann, Göhmann F, Göhmann F, Göhmann F Seel A, Jimbo M, Kato G, Kato G, Kitanine N, Kitanine N, Kitanine N Maillet J M Slavnov N A Terras V, Klümper A, Klümper A, Korepin V E, Nils P Hasenclever, Sato J, Sato J Shiroishi M Takahashi M, Slavnov N A, Suzuki M, Tsuboi Z   +28 more
core   +1 more source

Amyotrophic Lateral Sclerosis Prevalence Projection in 2040: A Less Rare Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To project ALS prevalence across multiple countries through 2040, accounting for both population aging and increased survival. Methods Data from the Piemonte and Valle d'Aosta ALS register (PARALS) was used to estimate the trends in incidence and prevalence from 2005 to 2019. Survival trends over this period were also assessed.
Rosario Vasta, Stefano Callegaro, Antonio Canosa, Umberto Manera, Maurizio Grassano, Francesca Palumbo, Sara Cabras, Enrico Matteoni, Francesca Di Pede, Filippo De Mattei, Salvatore Tafaro, Neil M. Thakur, Ryan Grosenick, Fabiola De Marchi, Letizia Mazzini, Cristina Moglia, Andrea Calvo, Kuldip D. Dave, Adriano Chiò   +18 more
wiley   +1 more source