Results 151 to 160 of about 291,935 (374)
Optimizing (Bio) Catalysis with Liquid‐Liquid Phase Separation Systems
ChemSystemsChem, EarlyView.This review highlights how LLPS creates membraneless compartments involved in different scenarios in nature. It further explores different examples that focus on the development of synthetic coacervates that enhance catalytic efficiency by concentrating reactants, or by the direct influence of the coacervates building blocks themselves.
David Q. P. Reis +4 more
wiley +1 more source
Evaluating the Competency of a First-Order Ontology
, 2015 We report on the results of evaluating the competency of a first-order ontology for its use with automated theorem provers (ATPs). The evaluation follows the adaptation of the methodology based on competency questions (CQs) [Gr\"uninger&Fox,1995] to the ...
Lucio, Paqui +2 more
core +1 more source
DLD‐HLNP/P@IR780 for efficient lung‐parenchyma accumulation to treat idiopathic pulmonary fibrosis
VIEW, EarlyView.DLD‐HLNP/P@IR780 was synthesized to target to lung and treat IPF by releasing pirfenidone. It could effectively traverse pulmonary ECB and accumulate in lung parenchyma by IR780 binding to CD300LF and MRC1 which are abundantly and specifically expressed on pulmonary endothelial cell and pulmonary macrophages.
Mengzhu Wang +3 more
wiley +1 more source
Júpiter Supremo Sumo: uma inscrição inédita de Orjais: (Covilhã) [PDF]
, 1982 José d’Encarnação +1 more
openalex +1 more source
Blood, 2006 Abstract Many proteins are known to undergo small ubiquitin-related modifier (SUMO) modification by an E1-, E2-, and E3-dependent ligation process. Recognition that protein inhibitor of activated signal transducers and activators of transcription (STATs) (PIAS) proteins are SUMO E3 ligases raised the possibility that STATs may also be ...
Ali A. Yunus +4 more
openaire +4 more sources
Compartmentalisation in cAMP signalling: A phase separation perspective
British Journal of Pharmacology, EarlyView.Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley +1 more source
Liquid–Liquid Phase Separation in Major Hallmarks of Cancer
Cell Proliferation, EarlyView.Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie +10 more
wiley +1 more source
Viral Immediate-Early Proteins Abrogate the Modification by SUMO-1 of PML and Sp100 Proteins, Correlating with Nuclear Body Disruption [PDF]
, 1999 Stefan Müller, Anne Dejean
openalex +1 more source
Deciphering SCN2A: A comprehensive review of rodent models of Scn2a dysfunction
Epilepsia, EarlyView.Abstract SCN2A encodes for the alpha subunit of the voltage‐gated sodium channel NaV1.2, which is involved in action potential initiation and backpropagation in excitatory neurons. Currently, it is one of the highest monogenetic risk factors for both epilepsy and autism spectrum disorder.
Katelin E. J. Scott +2 more
wiley +1 more source