Results 161 to 170 of about 46,190 (264)

The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle

The FEBS Journal, Volume 293, Issue 12, Page 3485-3501, June 2026.
DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh, Ofrah Faust, Rina Rosenzweig   +2 more
wiley   +1 more source

Lock, relax, load, and shoot: a molecular perspective on Nedd4 regulation

The FEBS Journal, Volume 293, Issue 11, Page 3097-3110, June 2026.
Structural basis of inactive and active states of the Nedd4 HECT E3 ligase subfamily, following a ‘lock, relax, load, and shoot’ mechanism. In the locked, autoinhibited state, intramolecular domain interactions restrain the HECT domain. Relaxation releases these restraints, allowing loading of ubiquitin onto the catalytic cysteine, followed by the ...
Masa Janosev, Tomas Obsil, Veronika Obsilova   +2 more
wiley   +1 more source

SUMO-Cadyts calibration with limited data quality

, 2017
Traffic simulation has been often used to support decision making in traffic management. Such simulation requires a large amount of fine data which cannot be easily obtained in practice especially when a large network is considered.
Flötteröd, Yun-Pang
core  

Selective targeting of cortactin tandem repeat acetylation by human lysine deacetylases

The FEBS Journal, Volume 293, Issue 12, Page 3528-3544, June 2026.
Cortactin function is regulated by acetylation at several lysine residues within its tandem repeat region. Using genetic code expansion to generate cortactin variants containing precisely defined acetylation marks, we show that HDAC6 is the primary enzyme removing these modifications, with SIRT1 and SIRT2 also acting at selected sites but with lower ...
Jan Komarek, Miroslava Vosahlikova, Zsofia Kutil, Zora Novakova, Julia Kudlacova, Ruzena Tuckova, Marat Meleshin, Barbora Havlinova, Pavlina Jaklova, Jana Ptackova, Cordelia Schiene‐Fischer, Mike Schutkowski, Cyril Barinka   +12 more
wiley   +1 more source

Ischemia‐Induced Post‐Translational Modifications of GLT‐1 Mediate Aberrant Trafficking and Impaired Glutamate Uptake

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
Ischemic insult causes hyper‐glutamatergic signaling and neuronal death. The astrocytic transporter GLT‐1, which clears extracellular glutamate, is internalized and degraded in response to ischemia. We found that lysine‐directed post‐translational modifications (particularly ubiquitination) of the C‐terminal domain drive aberrant trafficking ...
Simran Kaur Gill, Katelyn Louise Reeb, Max Kroll, Ole V. Mortensen, Andréia C. K. Fontana   +4 more
wiley   +1 more source

Protocol for SUMO fusion-based functional rescue of SUMOylation-defective protein in Drosophila. [PDF]

STAR Protoc
Imai R, Wu Y, Kawamura R, Murano K.
europepmc   +1 more source

The Structure of Carboxyl Methyltransferase Provides Insights Into the Substrate Specificity and Divergent Evolution of Iridoid

Plant Biotechnology Journal, Volume 24, Issue 6, Page 3708-3722, June 2026.
ABSTRACT Iridoids constitute a prominent class of plant‐specialised metabolites, with carbocyclic iridoids (e.g., geniposide) and secoiridoids (e.g., loganin) diverging early in their biosynthetic pathways. This divergence is marked by substrate‐specific carboxyl methyltransferases—GjGAMT and CrLAMT—that catalyse the decisive methylation step in ...
Li Li, Zhiteng Luo, Zhaoyin He, Jie Tang, Wuke Wei, Ruoting Zhan, Huihao Zhou, Dongming Ma   +7 more
wiley   +1 more source

Dynamic sumoylation is essential in yeast for suppressing stress-induced gene expression in non-stress conditions. [PDF]

Nucleic Acids Res
Moallem M, McNeil JB, Bergey BG, Rosonina E.   +3 more
europepmc   +1 more source

AaSIZ1‐Mediated SUMOylation of AaMYB31 Positively Regulates Freezing Tolerance in Actinidia arguta

Plant Biotechnology Journal, Volume 24, Issue 6, Page 3897-3921, June 2026.
ABSTRACT Several studies revealed that wax accumulation enhances plant tolerance to cold stress. However, the molecular regulation mechanism of wax synthesis under cold stress is still unclear in Actinidia arguta, a hardy kiwifruit species. Here, we found that cold stress significantly induces wax accumulation in Actinidia arguta leaves, which is ...
Linyao Liu, Lei Cao, Na Tang, Wangmei Ren, Zhili Zhu, Rong Wang, Minghao Xiang, Jinliang Sun, Xuan Zhang, Feng Zhang, Yunzhi Lin, Yuting Kong, Zhihui Jiang, Lihuan Wang, Yongsheng Liu, Cheng Zhang, Pengpeng Zheng   +16 more
wiley   +1 more source

Different strategies to enhance the solubility of acylsucrose transferase PaxASAT1 expression in <i>Escherichia coli</i>. [PDF]

Biochem Biophys Rep
Han L, Yu X, Ning Y, Wang C, Lu C, Dong Z, Liu C, Ni X, Chen Z.   +8 more
europepmc   +1 more source