Results 1 to 10 of about 1,958,216 (236)
SUMO-specific Isopeptidases Tuning Cardiac SUMOylation in Health and Disease
Frontiers in Molecular Biosciences, 2021 SUMOylation is a transient posttranslational modification with small-ubiquitin like modifiers (SUMO1, SUMO2 and SUMO3) covalently attached to their target-proteins via a multi-step enzymatic cascade.
Paul W. Hotz +2 more
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Journal of Medicinal Chemistry, 2021 SUMOylation is a reversible post-translational modification that regulates protein function through covalent attachment of small ubiquitin-like modifier (SUMO) proteins. The process of SUMOylating proteins involves an enzymatic cascade, the first step of
Steven Langston +52 more
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Super-resolution study of PIAS SUMO E3-ligases in hippocampal and cortical neurons
European Journal of Histochemistry, 2021 The SUMOylation machinery is a regulator of neuronal activity and synaptic plasticity. It is composed of SUMO isoforms and specialized enzymes named E1, E2 and E3 SUMO ligases.
Andrea Conz +4 more
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Site-Specific Protein Ubiquitylation Using an Engineered, Chimeric E1 Activating Enzyme and E2 SUMO Conjugating Enzyme Ubc9 [PDF]
ACS Central Science, 2022 Ubiquitylation—the attachment of ubiquitin (Ub) to proteins in eukaryotic cells—involves a vast number of enzymes from three different classes, resulting in heterogeneous attachment sites and ubiquitin chains.
Gaku Akimoto +2 more
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SUMO conjugation – a mechanistic view
Biomolecular Concepts, 2017 The regulation of protein fate by modification with the small ubiquitin-related modifier (SUMO) plays an essential and crucial role in most cellular pathways.
Pichler Andrea +3 more
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Chemical Synthesis of Atomically Tailored SUMO E2 Conjugating Enzymes for the Formation of Covalently Linked SUMO–E2–E3 Ligase Ternary Complexes [PDF]
Journal of the American Chemical Society, 2019 E2 conjugating enzymes are the key catalytic actors in the transfer of ubiquitin, SUMO, and other ubiquitin-like modifiers to their substrate proteins.
Yinfeng Zhang +5 more
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A Chemical and Enzymatic Approach to Study Site-Specific Sumoylation. [PDF]
PLoS ONE, 2015 A variety of cellular pathways are regulated by protein modifications with ubiquitin-family proteins. SUMO, the Small Ubiquitin-like MOdifier, is covalently attached to lysine on target proteins via a cascade reaction catalyzed by E1, E2, and E3 enzymes.
Claudio P Albuquerque +5 more
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Not So Slim Anymore—Evidence for the Role of SUMO in the Regulation of Lipid Metabolism
Biomolecules, 2020 One of the basic building blocks of all life forms are lipids—biomolecules that dissolve in nonpolar organic solvents but not in water. Lipids have numerous structural, metabolic, and regulative functions in health and disease; thus, complex networks of ...
Amir Sapir
doaj +2 more sources
PLoS ONE, 2022 RiPPs (ribosomally-synthesized and post-translationally modified peptides) are a class of pharmaceutically-relevant natural products expressed as precursor peptides before being enzymatically processed into their final functional forms.
Emerson Glassey +4 more
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Redox regulation of SUMO enzymes is required for ATM activity and survival in oxidative stress. [PDF]
EMBO J, 2016 Stankovic-Valentin N +4 more
europepmc +2 more sources