Results 91 to 100 of about 1,958,325 (325)

SUMOylation inhibits FOXM1 activity and delays mitotic transition [PDF]

, 2014
The forkhead box transcription factor FOXM1 is an essential effector of G2/M-phase transition, mitosis and the DNA damage response. As such, it is frequently deregulated during tumorigenesis. Here we report that FOXM1 is dynamically modified by SUMO1 but
Brosens, Jan J., Coombes, R. C., Dunsby, C. W., French, P. M., Gomes, Ana R., Karunarathna, U., Kelly, D. J., Khongkow, P., Kongsema, M., Lam, Eric W.-F., Langer, J. K., Man, Cornelia W-Y., Myatt, Stephen S., Zona, Stefania   +13 more
core   +1 more source

Recombinant Proteins: A Molecular Tool to Understand Marine Adhesion and to Advance Biomaterials

Advanced Healthcare Materials, EarlyView.
The production of recombinant proteins represents a fundamental step in the characterisation of marine invertebrate adhesives and in the development of bio‐inspired glues. The association of these proteins with other components such as ions, proteins, polysaccharides, or polymers enables the fabrication of biomaterials for various healthcare ...
Alessandra Whaite, Emilie Duthoo, Mathilde Lefevre, Elise Hennebert, Patrick Flammang   +4 more
wiley   +1 more source

SUMOylation in Giardia lamblia: A Conserved Post-Translational Modification in One of the Earliest Divergent Eukaryotes

Biomolecules, 2012
Post-translational modifications are able to regulate protein function and cellular processes in a rapid and reversible way. SUMOylation, the post-translational modification of proteins by the addition of SUMO, is a highly conserved process that seems to
Andrea S. Rópolo, María C. Touz, Nahuel Zamponi, María C. Merino, Cecilia V. Vranych   +4 more
doaj   +1 more source

The ubiquitin-like proteins SMT3 and SUMO-1 are conjugated by the UBC9 E2 enzyme [PDF]

Proceedings of the National Academy of Sciences, 1998
The ubiquitin-like protein SMT3 fromSaccharomyces cerevisiaeand SUMO-1, its mammalian homolog, can be covalently attached to other proteins posttranslationally. Conjugation of ubiquitin requires the activities of ubiquitin-activating (E1) and -conjugating (E2) enzymes and proceeds via thioester-linked enzyme-ubiquitin intermediates. Herein we show that
Sylvia E. Schwarz, Kai Matuschewski, Dimitris Liakopoulos, Martin Scheffner, Stefan Jentsch   +4 more
openalex   +4 more sources

Regulation of SUMO Modification [PDF]

, 2007
The small ubiquitin related modifier SUMO is a posttranslational modifier that functions in a wide range of cellular processes like intracellular transport, cell cycle regulation, DNA repair and regulation of transcription.
Knipscheer, P.M. (Puck Maria)
core   +1 more source

Structural basis for the RING catalyzed synthesis of K63 linked ubiquitin chains [PDF]

, 2015
This work was supported by grants from Cancer Research UK (C434/A13067), the Wellcome Trust (098391/Z/12/Z) and Biotechnology and Biological Sciences Research Council (BB/J016004/1).The RING E3 ligase catalysed formation of lysine 63 linked ubiquitin ...
A Plechanovová, A Plechanovová, A Rojas-Fernandez, AA Yunus, AJ McCoy, Anna Plechanovová, AP VanDemark, CE Berndsen, CE Berndsen, CM Guzzo, D Reverter, DC Scott, E Krissinel, Ellis G Jaffray, Emma Branigan, G Winter, GN Murshudov, H Dou, James H Naismith, JN Pruneda, L Chang, L Spyracopoulos, M Scheffner, M Zhang, MB Metzger, MD Winn, MH Tatham, MH Tatham, MJ Eddins, MJ Lewis, P Emsley, P Evans, PY Wu, R Vyas, RM Hofmann, Ronald T Hay, S McKenna, S McKenna, TF Moraes, VB Chen, W Kabsch, Y Galanty, Y Yin   +42 more
core   +4 more sources

Polyhalogenated Carbazole Impairs Dopaminergic Neurons through Dysregulation of Liquid–Liquid Phase Separation in Caenorhabditis elegans

Advanced Science, EarlyView.
Polyhalogenated carbazoles (PHCZ), persistent environmental contaminants, preferentially accumulate in neuronal tissues. Studies using Caenorhabditis elegans and human neuronal cell lines reveal that PHCZ induce dopaminergic neurodegeneration by promoting liquid–liquid phase separation of α‐synuclein, reducing condensate fluidity, impairing ...
Yuhang Luo, Hongbo Xu, Pei Peng, Xinhe Lu, Qian Zhou, Ziqing Gao, Cheng Tang, Hongyan Yin, Ying Cai, Gaga Mahai, Zhiqiang Zhu, Zuojun Liu, Hanzeng Li, Shunqing Xu   +13 more
wiley   +1 more source

SUMO Modification Stabilizes Enterovirus 71 Polymerase 3D To Facilitate Viral Replication. [PDF]

, 2016
Accumulating evidence suggests that viruses hijack cellular proteins to circumvent the host immune system. Ubiquitination and SUMOylation are extensively studied posttranslational modifications (PTMs) that play critical roles in diverse biological ...
Gong, P, Hu, Q, Ke, X, Liu, Y, Meng, J, Shu, B, Wang, H, Zhang, Y, Zheng, C, Zheng, Z   +9 more
core   +1 more source

E2 enzymes: more than just middle men

Cell Research, 2016
Ubiquitin-conjugating enzymes (E2s) are the central players in the trio of enzymes responsible for the attachment of ubiquitin (Ub) to cellular proteins.
Mikaela D Stewart, Tobias Ritterhoff, R. Klevit, P. Brzovic   +3 more
semanticscholar   +1 more source

SUMO chain formation relies on the amino-terminal region of SUMO-conjugating enzyme and has dedicated substrates in plants

Biochemical Journal, 2018
The small ubiquitin-related modifier (SUMO) conjugation apparatus usually attaches single SUMO moieties to its substrates, but SUMO chains have also been identified. To better define the biochemical requirements and characteristics of SUMO chain formation, mutations in surface-exposed Lys residues of Arabidopsis SUMO-conjugating enzyme (SCE) were ...
Andreas Bachmair, Ionida Ziba, Lilian Nehlin, Konstantin Tomanov   +3 more
openaire   +2 more sources