Results 111 to 120 of about 1,958,325 (325)
Journal of Parasitology Research, 2012 Small ubiquitin-related modifier (SUMO) is involved in numerous cellular processes including protein localization, transcription, and cell cycle control.
Roberta Verciano Pereira +5 more
doaj +1 more source
Epigenetic silencing of spermatocyte-specific and neuronal genes by SUMO modification of the transcription factor Sp3. [PDF]
PLoS Genetics, 2010 SUMO modification of transcription factors is linked to repression of transcription. The physiological significance of SUMO attachment to a particular transcriptional regulator, however, is largely unknown.
Bastian Stielow +7 more
doaj +1 more source
Geminivirus replication protein decreases PCNA sumoylation at two acceptor sites [PDF]
, 2019 Geminiviruses are plant viruses with circular, single-stranded DNA (ssDNA) genomes that infect a broad range of plants causing substantial crop diseases worldwide.
Arroyo-Mateos, Manuel +9 more
core
Nature Communications, 2019 Modification with SUMO regulates many eukaryotic proteins. Down-regulation of sumoylated forms of proteins involves either their desumoylation, and hence recycling of the unmodified form, or their proteolytic targeting by ubiquitin ligases that recognize
A. M. Sriramachandran +8 more
semanticscholar +1 more source
Identification of SUMO activating enzyme 1 inhibitors utilizing virtual screening approach [PDF]
Journal of Cheminformatics, 2014 Sumoylation is a post-translational modification affecting diverse cellular processes including DNA replication and repair, chromosome packing and dynamics, genome integrity, nuclear transport, signal transduction and cell proliferation [1]. Sumoylation involves the covalent attachment of a small ubiquitin like modifier (SUMO) protein to e-amino group ...
Minoru Yoshida +4 more
openaire +2 more sources
cGAS Inhibits ALDH2 to Suppress Lipid Droplet Function and Regulate MASLD Progression
Advanced Science, EarlyView.cGAS is a cytosolic DNA sensor known for innate immune defense. cGAS binds and suppresses ALDH2 are showed, limiting acetyl‐CoA production. cGAS loss activates ALDH2, promoting histone acetylation, lipogenesis, and lipid droplets accumulation. cGas‐/‐ mice on a high‐fat diet show signs of worsened MASLD.
Ying Wang +14 more
wiley +1 more source
A mechanistic view of the role of E3 in sumoylation.
PLoS Computational Biology, 2010 Sumoylation, the covalent attachment of SUMO (Small Ubiquitin-Like Modifier) to proteins, differs from other Ubl (Ubiquitin-like) pathways. In sumoylation, E2 ligase Ubc9 can function without E3 enzymes, albeit with lower reaction efficiency.
Melda Tozluoğlu +3 more
doaj +1 more source
Identification of the Enzyme Required for Activation of the Small Ubiquitin-like Protein SUMO-1 [PDF]
Journal of Biological Chemistry, 1999 The ubiquitin-like protein SUMO-1 is conjugated to a variety of proteins including Ran GTPase-activating protein 1 (RanGAP1), IkappaBalpha, and PML. SUMO-1-modified proteins display altered subcellular targeting and/or stability. We have purified the SUMO-1-activating enzyme from human cells and shown that it contains two subunits of 38 and 72 kDa ...
Graham D. Kemp +3 more
openaire +3 more sources
Advanced Science, EarlyView.Liver aging is characterized by a decline in the expression of the SUMO‐conjugating enzyme Ubc9, resulting in reduced SUMOylation levels in hepatocytes, particularly in the case of ribosomal protein RPL3. Disruption of RPL3 SUMOylation increases its nuclear translocation. Interestingly, ribosome‐free RPL3 facilitates the recruitment of helicase DHX9 to
Hao Xie +22 more
wiley +1 more source
Cell Reports, 2019 Summary: Signaling by the ubiquitin-related SUMO pathway relies on coordinated conjugation and deconjugation events. SUMO-specific deconjugating enzymes counterbalance SUMOylation, but comprehensive insight into their substrate specificity and regulation
Kristina Wagner +9 more
doaj +1 more source