Results 111 to 120 of about 28,838 (280)

Pan2‐Pan3 Complex‐Mediated Deadenylation Enforces mRNA Quality Control for Infection of the Rice Blast Fungus

Advanced Science, EarlyView.
Discovery that deadenylation, rather than transcription, acts as the rate‐limiting step for developmental timing in a plant pathogen. Evidence that P‐body integrity and mRNA decay are mechanistically coupled to rapid cellular differentiation under environmental stress. Identification of Pan2‐Pan3 as a pathogen‐specific “meta‐virulence factor” absent in
Ziwei Lv, Junting Feng, Shenxian Zhou, Zhiguang Qu, Jun Peng, Xiao‐Lin Chen, Deng Chen   +6 more
wiley   +1 more source

Structural basis for the human SENP5’s SUMO isoform discrimination

Nature Communications
Post-translational SUMO modification is a widespread mechanism for regulating protein function within cells. In humans, SUMO-conjugated proteins are partially regulated by the deconjugating activity of six SENP family members. The proteolytic activity of
Lucía Sánchez-Alba, Li Ying, Matthew D. Maletic, Anna De Bolòs, Helena Borràs-Gas, Bing Liu, Nathalia Varejão, Virginia Amador, Monique P. C. Mulder, David Reverter   +9 more
doaj   +1 more source

Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiae. [PDF]

, 2017
Genome rearrangements result in mutations that underlie many human diseases, and ongoing genome instability likely contributes to the development of many cancers.
Kolodner, Richard D, Putnam, Christopher D   +1 more
core   +1 more source

Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function [PDF]

, 2002
This work was supported by grants from the NIH (R01CA86072 to R.G.P. and R01CA72038-01 to S.A.W.F.) and The Susan Komen Breast Cancer Foundation (to R.G.P.). R.T.H. and E.J. were supported by the Medical Research Council. Y.-G.Y.
Chang, Chawnshang, Fu, Maofu, Fuqua, Suzanne A W, Hay, Ronald Thomas, Hopp, Torsten, Jaffray, E, Janne, OA, Palvimo, Jorma J, Pestell, RG0, Sakamaki, Toshiyuki, Wang, Chenguang, Wang, Jian, Yeung, YG, Zhang, Xueping   +13 more
core   +1 more source

Over‐Expression of a Phycocyanin‐Interferon Fusion and Differential Cleaving Efficiency in Cyanobacteria (Synechocystis sp. PCC 6803)

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Recombinant protein expression in heterologous biological systems is an expanding field in synthetic biology. Photosynthetic organisms have the potential to provide an efficient low‐cost platform for recombinant protein production because they require minimal growth nutrients and are less susceptible to zoonotic and other contaminants ...
Bharat Kumar Majhi, Anastasios Melis
wiley   +1 more source

Dissecting Distinct Roles of NEDDylation E1 Ligase Heterodimer APPBP1 and UBA3 Reveals Potential Evolution Process for Activation of Ubiquitin-related Pathways. [PDF]

, 2018
Despite the similar enzyme cascade in the Ubiquitin and Ubiquitin-like peptide(Ubl) conjugation, the involvement of single or heterodimer E1 activating enzyme has been a mystery.
Gaieb, Zied, Kung, Raphael, Le, Frank, Liao, Jiayu, Malik-Chaudhry, Harbani Kaur, Morikis, Dimitrios, Reyes, Michael, Saavedra, Amanda   +7 more
core  

Chemical Methods for Peptide and Protein Backbone Cleavage

ChemistryEurope, EarlyView.
Protein cleavage plays essential roles in biology and is powerful for protein manipulation and functionalization as well as in recombinant expression and purification. Here, the historical background and most recent examples of chemical methods for protein and peptide backbone cleavage are discussed (part of the figure was generated in BioRender).
Miguel Angel Alena‐Rodriguez, Christian A. Olsen   +1 more
wiley   +1 more source

Negative Regulation of TLR Inflammatory Signaling by the SUMO-deconjugating Enzyme SENP6

PLoS Pathogens, 2013
The signaling of Toll-like receptors (TLRs) induces host defense against microbial invasion. Protein posttranslational modifications dynamically shape the strength and duration of the signaling pathways. It is intriguing to explore whether de-SUMOylation could modulate the TLR signaling.
Xing Liu, Wei Chen, Qiang Wang, Li Li, Chen Wang   +4 more
openaire   +4 more sources

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Role of Desumoylation in the Development of Prostate Cancer

Neoplasia: An International Journal for Oncology Research, 2006
SUMO is a novel ubiquitin-like protein that can covalently modify a large number of nuclear proteins. SUMO modification has emerged as an important regulatory mechanism for protein function and localization.
Jinke Cheng, Tasneem Bawa, Peng Lee, Limin Gong, Edward T.H. Yeh   +4 more
doaj   +1 more source