Results 131 to 140 of about 1,958,325 (325)

The ubiquitin system and jasmonate signaling [PDF]

, 2016
The ubiquitin (Ub) system is involved in most, if not all, biological processes in eukaryotes. The major specificity determinants of this system are the E3 ligases, which bind and ubiquitinate specific sets of proteins and are thereby responsible for ...
Goossens, Alain, Nagels Durand, Astrid, Pauwels, Laurens   +2 more
core   +3 more sources

Breaking barriers: the cGAS‐STING pathway as a novel frontier in cancer immunotherapy

Cancer Communications, EarlyView.
Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan, Ximin Tan, Bin Song, Ming Yi, Qian Chu, Kongming Wu   +5 more
wiley   +1 more source

Regulation of genes for ubiquitination and SUMO‐specific protease involved in larval development of the silkworm, Bombyx mori

Development, Growth and Differentiation, 2020
Protein modifications with highly conserved small proteins, such as ubiquitin (Ub) and small ubiquitin‐like modifier (SUMO), regulate various cellular processes; however, the contribution of these protein modifications to larval development in insects ...
Tsuyuki Kitagawa, S. Takiya
semanticscholar   +1 more source

Comparative Structural Analysis of Escherichia Coli Cyay at Room and Cryogenic Temperatures Using Macromolecular and Serial Crystallography

ChemBioChem, EarlyView.
Room‐temperature (RT) crystallography of E. coli CyaY, the bacterial frataxin homolog, reveals subtle but functionally relevant differences from cryogenic structures. The conserved fold shows distinct side‐chain conformations and water networks, highlighting dynamics often hidden at low temperatures.
Alaleh Shafiei, Nilufer Baldir, Jongbum Na, Jin Hae Kim, Hasan DeMirci   +4 more
wiley   +1 more source

Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function [PDF]

, 2002
This work was supported by grants from the NIH (R01CA86072 to R.G.P. and R01CA72038-01 to S.A.W.F.) and The Susan Komen Breast Cancer Foundation (to R.G.P.). R.T.H. and E.J. were supported by the Medical Research Council. Y.-G.Y.
Chang, Chawnshang, Fu, Maofu, Fuqua, Suzanne A W, Hay, Ronald Thomas, Hopp, Torsten, Jaffray, E, Janne, OA, Palvimo, Jorma J, Pestell, RG0, Sakamaki, Toshiyuki, Wang, Chenguang, Wang, Jian, Yeung, YG, Zhang, Xueping   +13 more
core   +1 more source

Total Chemical Synthesis of SUMO and SUMO‐Based Probes for Profiling the Activity of SUMO‐Specific Proteases

Angewandte Chemie, 2018
SUMO is a post‐translational modifier critical for cell cycle progression and genome stability that plays a role in tumorigenesis, thus rendering SUMO‐specific enzymes potential pharmacological targets. However, the systematic generation of tools for the
Monique P. C. Mulder, R. Merkx, Katharina F. Witting, Dharjath S Hameed, Dris El Atmioui, Lindsey T. Lelieveld, F. Liebelt, J. Neefjes, Ilana Berlin, A. Vertegaal, H. Ovaa   +10 more
semanticscholar   +1 more source

Chemical Methods for Peptide and Protein Backbone Cleavage

ChemistryEurope, EarlyView.
Protein cleavage plays essential roles in biology and is powerful for protein manipulation and functionalization as well as in recombinant expression and purification. Here, the historical background and most recent examples of chemical methods for protein and peptide backbone cleavage are discussed (part of the figure was generated in BioRender).
Miguel Angel Alena‐Rodriguez, Christian A. Olsen   +1 more
wiley   +1 more source

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, EarlyView.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Innate immune activating ligand SUMOylation affects tumor cell recognition by NK cells [PDF]

, 2017
Natural Killer cells are innate lymphocytes involved in tumor immunosurveillance. They express activating receptors able to recognize self-molecules poorly expressed on healthy cells but up-regulated upon stress conditions, including transformation ...
Cippitelli, M, De Turris, V, Fionda, C, Gismondi, A, Lecce, M, Molfetta, R°, Paolini, R, Petrucci, Mt, Quatrini, L, Ricciardi, Mr, Santoni, A, Stabile, H, Zitti, B°, °these Authors Contributed Equally To The, Work   +13 more
core   +1 more source