Results 141 to 150 of about 1,958,325 (325)
Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire
PROTEOMICS, EarlyView.ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley +1 more source
Frontiers in Genetics, 2016 Ubiquitin and the ubiquitin-like modifier SUMO are intimately connected with the cellular response to various types of DNA damage. A striking feature is the local accumulation of these proteinaceous post-translational modifications in the direct vicinity
Nico P. Dantuma, Annika ePfeiffer
doaj +1 more source
Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction
PROTEOMICS, EarlyView.ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella +6 more
wiley +1 more source
Role of Desumoylation in the Development of Prostate Cancer
Neoplasia: An International Journal for Oncology Research, 2006 SUMO is a novel ubiquitin-like protein that can covalently modify a large number of nuclear proteins. SUMO modification has emerged as an important regulatory mechanism for protein function and localization.
Jinke Cheng +4 more
doaj +1 more source
Dissecting Distinct Roles of NEDDylation E1 Ligase Heterodimer APPBP1 and UBA3 Reveals Potential Evolution Process for Activation of Ubiquitin-related Pathways. [PDF]
, 2018 Despite the similar enzyme cascade in the Ubiquitin and Ubiquitin-like peptide(Ubl) conjugation, the involvement of single or heterodimer E1 activating enzyme has been a mystery.
Gaieb, Zied +7 more
core
The ubiquitin E3/E4 ligase, UBE4A, fine-tunes protein ubiquitylation and accumulation at sites of DNA damage facilitating double-strand break repair [PDF]
, 2018 Double-strand breaks (DSBs) are critical DNA lesions that robustly activate the elaborate DNA damage response (DDR) network. We identified a critical player in DDR fine-tuning - the E3/E4 ubiquitin ligase, UBE4A.
Baranes Bachar, Keren +4 more
core +1 more source
Chemical Tools and Biochemical Assays for SUMO Specific Proteases (SENPs)
ACS Chemical Biology, 2019 SUMOylation is a reversible and highly dynamic post-translational modification of target proteins by small ubiquitin-like modifiers (SUMO). It is orchestrated by SUMO-activating, -conjugating, and -ligating enzymes in a sequential manner and is important
Yuqing Jia +3 more
semanticscholar +1 more source
The SIRT1 N‐Terminal Domain as a Common Binding Interface for PPARγ Anchoring
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Insulin resistance, a global health threat linked to type 2 diabetes and obesity, can be addressed by modulating the activity of the Sirtuin 1 (SIRT1), a deacetylase that enhances insulin sensitivity by deacetylating the Peroxisome Proliferator‐Activated Receptor Gamma (PPARγ) at lysine 268 and 293. Understanding the binding interfaces between
Caique Camargo Malospirito +7 more
wiley +1 more source
Optimizing (Bio) Catalysis with Liquid‐Liquid Phase Separation Systems
ChemSystemsChem, EarlyView.This review highlights how LLPS creates membraneless compartments involved in different scenarios in nature. It further explores different examples that focus on the development of synthetic coacervates that enhance catalytic efficiency by concentrating reactants, or by the direct influence of the coacervates building blocks themselves.
David Q. P. Reis +4 more
wiley +1 more source