Results 11 to 20 of about 28,838 (280)
Medicine in Drug DiscoveryThe heterodimeric E1 complex, Aos1-Uba2, catalyzes the first adenylation activation of the SUMO1 peptide in the SUMOylation cascade. The reaction affinity and dynamics of the Aos1-Uba2 heterodimer during the first step activation have yet to be ...
Ling Jiang +3 more
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Auto-sumoylation of the yeast Ubc9 E2 SUMO-conjugating enzyme extends cellular lifespan [PDF]
Nature CommunicationsCalorie restriction (CR) provides anti-aging benefits through diverse processes, such as reduced metabolism and growth and increased mitochondrial activity. Although controversy still exists regarding CR-mediated lifespan effects, many researchers are seeking interventions that mimic the effects of CR.
Dong-Won Jeong +10 more
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Auto-sumoylation of the Ubc9 E2 SUMO-conjugating Enzyme Extends Cellular Lifespan [PDF]
Abstract Calorie restriction (CR) provides anti-aging benefits through diverse processes, such as reduced metabolism and growth and increased mitochondrial activity. Although controversy still exists regarding CR-mediated lifespan effects, many researchers are seeking interventions that mimic the effects of CR.
Hong‐Yeoul Ryu +9 more
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Protein SUMOylation and Its Research Progress in Maize
Guangdong nongye kexue, 2023 Small ubiquitin-like modification (SUMOylation) is a crucial post-translational modification of proteins that plays a vital role in various biological processes in plants.
Ruiqiang LAI +5 more
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Super-resolution study of PIAS SUMO E3-ligases in hippocampal and cortical neurons
European Journal of Histochemistry, 2021 The SUMOylation machinery is a regulator of neuronal activity and synaptic plasticity. It is composed of SUMO isoforms and specialized enzymes named E1, E2 and E3 SUMO ligases.
Andrea Conz +4 more
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SUMO-specific Isopeptidases Tuning Cardiac SUMOylation in Health and Disease
Frontiers in Molecular Biosciences, 2021 SUMOylation is a transient posttranslational modification with small-ubiquitin like modifiers (SUMO1, SUMO2 and SUMO3) covalently attached to their target-proteins via a multi-step enzymatic cascade.
Paul W. Hotz +2 more
doaj +1 more source
Diversification of SUMO-Activating Enzyme in Arabidopsis: Implications in SUMO Conjugation [PDF]
Molecular Plant, 2013 Sumoylation is an essential posttranslational modification that participates in many biological processes including stress responses. However, little is known about the mechanisms that control Small Ubiquitin-like MOdifier (SUMO) conjugation in vivo. We have evaluated the regulatory role of the heterodimeric E1 activating enzyme, which catalyzes the ...
L. Castano-Miquel +6 more
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Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration. [PDF]
PLoS Genetics, 2014 Post-translational modification of proteins by small ubiquitin-related modifier (SUMO) is reversible and highly evolutionarily conserved from yeasts to humans.
Jiang Fu +6 more
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Dynamic SUMO remodeling drives a series of critical events during the meiotic divisions in Caenorhabditis elegans. [PDF]
PLoS Genetics, 2018 Chromosome congression and segregation in C. elegans oocytes depend on a complex of conserved proteins that forms a ring around the center of each bivalent during prometaphase; these complexes are then removed from chromosomes at anaphase onset and ...
Amanda C Davis-Roca +3 more
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