Results 191 to 200 of about 1,958,325 (325)

Ubiquitin- and ubiquitin-like proteins-conjugating enzymes (E2s) in breast cancer [PDF]

, 2018
Breast cancer is the most common malignancy in women and a significant cause of morbidity and mortality. Sub-types of breast cancer defined by the expression of steroid hormones and Her2/Neu oncogene have distinct prognosis and undergo different ...
Voutsadakis, Ioannis
core  

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Isolation, screening and characterization of microorganisms with potential for biofuels production [PDF]

, 2012
Tese de mestrado. Biologia (Microbiologia Aplicada). Universidade de Lisboa, Faculdade de Ciências, 2012Rapid global population growth has increased the demand for food and energy supply.
Teixeira, Pedro Jorge Dias, 1989-
core  

Accurate affinity models for SH2 domains from peptide binding assays and free‐energy regression

Protein Science, Volume 34, Issue 11, November 2025.
Abstract Short linear peptide motifs play important roles in phosphotyrosine‐dependent signaling networks. They can act both as substrates of kinases and phosphatases and as ligands of peptide binding domains. SH2 domains bind specifically to tyrosine‐phosphorylated proteins, with the affinity of the interaction depending strongly on the flanking ...
Dejan Gagoski, H. Tomas Rube, Chaitanya Rastogi, Lucas A. N. Melo, Xiaoting Li, Rashmi Voleti, Neel H. Shah, Harmen J. Bussemaker   +7 more
wiley   +1 more source

Structural mechanisms for cold‐adapted activity of phosphoenolpyruvate carboxykinase

Protein Science, Volume 34, Issue 11, November 2025.
Abstract Temperature is a critical factor in enzyme function, as most enzymes are thermally activated. Across Earth's diverse environments (−20 to 120°C), enzymes have evolved to function optimally at their organism's growth temperature. Thermophilic enzymes must resist denaturation, while psychrophilic enzymes must maintain activity with limited ...
Matthew J. McLeod, Shauhin Yazdani, Sarah A. E. Barwell, Todd Holyoak   +3 more
wiley   +1 more source

Role of the Srs2-Rad51 Interaction Domain in Crossover Control in Saccharomyces cerevisiae. [PDF]

, 2019
Saccharomyces cerevisiae Srs2, in addition to its well-documented antirecombination activity, has been proposed to play a role in promoting synthesis-dependent strand annealing (SDSA).
Ede, Christopher, Gore, Steven, Guo, Xiaoge, Heyer, Wolf-Dietrich, Jenkins, Shirin S, Jinks-Robertson, Sue, Kowalczykowski, Stephen C, Liu, Jie, Veaute, Xavier   +8 more
core  

Correlating membrane‐protein dynamics with function: Integrating bioinformatics, molecular dynamics, and single‐molecule FRET

Protein Science, Volume 34, Issue 11, November 2025.
Abstract We present a strategy that deploys structural bioinformatics, molecular simulation, and single‐molecule Förster Resonance Energy Transfer (FRET) microscopy for observing the ligand‐dependent conformational dynamics of integral membrane proteins in situ.
Hugh R. Higinbotham, Christine A. Arbour, Barbara Imperiali   +2 more
wiley   +1 more source

Extensive TDDFT Benchmark Study of the Resonance Raman Spectra of Lumiflavin

Journal of Computational Chemistry, Volume 46, Issue 26, October 5, 2025.
An extensive computational TDDFT resonance Raman study of lumiflavin is presented including forty‐two different DFT functionals, benchmarked against the experimental spectra of FMN. The inclusion of resonance enhancements improved the agreement for most functionals.
Prokopis C. Andrikopoulos, Heba Halimeh
wiley   +1 more source

Human Schlafen 14 Cleavage of Short Double‐Stranded RNAs Underpins its Antiviral Activity

Advanced Science, Volume 12, Issue 37, October 6, 2025.
SLFN14 is associated with human diseases. SLFN14 is found to cleave RNAs containing short duplexes. The cryo‐EM structures of SLFN14 and SLFN14‐hairpin RNA complex reveal that SLFN14 assembles into a ring‐like dimer; two RNase domains form an RNA‐binding groove accommodating a hairpin RNA.
Mengyun Li, Dapeng Sun, Wei Hao, Hua Fu, Yueli Zhang, Zhijian Li, Bo Qin, Yumei Wang, Sheng Cui   +8 more
wiley   +1 more source

Progastrin Promotes Colorectal Cancer Stem Cell‐Like Properties via the Receptor PZR

Advanced Science, Volume 12, Issue 38, October 13, 2025.
The tumor microenvironment supports colorectal cancer (CRC) progression by maintaining cancer stem cells (CSCs) through progastrin (PG). This study identifies Protein Zero‐Related protein (PZR) as an essential receptor for PG activity, promoting CSC‐like signaling via SHP2/SRC/β‐catenin.
Julie Nguyen, Marie Lafitte, Maud Barbery, Kevin Espie, Maya Jeitany, Romain Larive, Jihane Vitre, Conception Paul, Yvan Boublik, Elise Fourgous, Valérie Simon, Audrey Sirvent, Madeline Neiveyans, Steeve Thirard, Lucile Bansard, Morgan Maillard, Nathalie Coutry, Jacques Colinge, Philippe Jay, Pierre Martineau, Michael Hahne, Julie Pannequin, Serge Roche   +22 more
wiley   +1 more source