Structural basis for the human SENP5’s SUMO isoform discrimination [PDF]
Nature CommunicationsPost-translational SUMO modification is a widespread mechanism for regulating protein function within cells. In humans, SUMO-conjugated proteins are partially regulated by the deconjugating activity of six SENP family members. The proteolytic activity of
Lucía Sánchez-Alba +9 more
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Host SUMOylation in bacterial infections and immune defense mechanisms [PDF]
Frontiers in MicrobiologySUMOylation, the covalent attachment of small ubiquitin-like modifier proteins (SUMO) to lysine residues of target substrates, has emerged as a crucial post-translational modification regulating various cellular processes.
Yuhua Xu +11 more
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HPV E6 proteins target Ubc9, the SUMO conjugating enzyme [PDF]
Virus Research, 2011 The human papillomavirus oncogenic protein, E6, interacts with a number of cellular proteins, and for some targets, E6 directs their degradation through the ubiquitin-proteasome pathway. Post-translational modification with ubiquitin-like modifiers, such as SUMO, also influences protein activities, protein-protein interactions, and protein stability ...
Phillip Heaton +3 more
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SUMO-G5C23-D208G@ZIF-F: A Novel Immobilized Enzyme with Enhanced Stability and Reusability for Organophosphorus Hydrolysis. [PDF]
Int J Mol SciWang S +8 more
europepmc +2 more sources
Characterization of SUMO-conjugating enzyme mutants in Schizosaccharomyces pombe identifies a dominant-negative allele that severely reduces SUMO conjugation [PDF]
Biochemical Journal, 2003 The phenotypes of mutants defective in the Schizosaccharomyces pombe SUMO (small, ubiquitin-like modifier)-conjugating enzyme Hus5 (the homologue of Ubc9) show that it is required for recovery from S-phase arrest. Unlike the case with ubiquitination, where ligases are required, SUMO-conjugating enzymes are sufficient for substrate recognition and ...
Jenny Ho, Felicity Z. Watts
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SUMO-Conjugating and SUMO-Deconjugating Enzymes from Arabidopsis1 [PDF]
Plant Physiology, 2006 Abstract Posttranslational protein modification by the small ubiquitin-like modifier (SUMO) is a highly dynamic and reversible process. To analyze the substrate specificity of SUMO-conjugating and -deconjugating enzymes from Arabidopsis (Arabidopsis thaliana), we reconstituted its SUMOylation cascade in vitro and tested the capacity of ...
T. Colby +3 more
semanticscholar +5 more sources
Protein SUMOylation and Its Research Progress in Maize
Guangdong nongye kexue, 2023 Small ubiquitin-like modification (SUMOylation) is a crucial post-translational modification of proteins that plays a vital role in various biological processes in plants.
Ruiqiang LAI +5 more
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Diversification of SUMO-Activating Enzyme in Arabidopsis: Implications in SUMO Conjugation [PDF]
Molecular Plant, 2013 Sumoylation is an essential posttranslational modification that participates in many biological processes including stress responses. However, little is known about the mechanisms that control Small Ubiquitin-like MOdifier (SUMO) conjugation in vivo. We have evaluated the regulatory role of the heterodimeric E1 activating enzyme, which catalyzes the ...
L. Castano-Miquel +6 more
openaire +4 more sources
Negative Regulation of TLR Inflammatory Signaling by the SUMO-deconjugating Enzyme SENP6
PLoS Pathogens, 2013 The signaling of Toll-like receptors (TLRs) induces host defense against microbial invasion. Protein posttranslational modifications dynamically shape the strength and duration of the signaling pathways. It is intriguing to explore whether de-SUMOylation could modulate the TLR signaling.
Xing Liu +4 more
openalex +6 more sources
Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration. [PDF]
PLoS Genetics, 2014 Post-translational modification of proteins by small ubiquitin-related modifier (SUMO) is reversible and highly evolutionarily conserved from yeasts to humans.
Jiang Fu +6 more
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