Not So Slim Anymore—Evidence for the Role of SUMO in the Regulation of Lipid Metabolism
Biomolecules, 2020 One of the basic building blocks of all life forms are lipids—biomolecules that dissolve in nonpolar organic solvents but not in water. Lipids have numerous structural, metabolic, and regulative functions in health and disease; thus, complex networks of ...
Amir Sapir
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Functional reconstitution of a tunable E3-dependent sumoylation pathway in Escherichia coli. [PDF]
PLoS ONE, 2012 SUMO (small ubiquitin-related modifier) is a reversible post-translational protein modifier that alters the localization, activity, or stability of proteins to which it is attached.
Sean P O'Brien, Matthew P DeLisa
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Discovery and engineering of enhanced SUMO protease enzymes [PDF]
Journal of Biological Chemistry, 2018 Small ubiquitin-like modifier (SUMO) is commonly used as a protein fusion domain to facilitate expression and purification of recombinant proteins, and a SUMO-specific protease is then used to remove SUMO from these proteins. Although this protease is highly specific, its limited solubility and stability hamper its utility as an in vitro reagent. Here,
Yue-Ting K, Lau +8 more
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Preserving genome integrity: The vital role of SUMO-targeted ubiquitin ligases
Cell Insight, 2023 Various post-translational modifications (PTMs) collaboratively fine-tune protein activities. SUMO-targeted ubiquitin E3 ligases (STUbLs) emerge as specialized enzymes that recognize SUMO-modified substrates through SUMO-interaction motifs and ...
Jinhua Han, Yanhua Mu, Jun Huang
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HPV E6 proteins target Ubc9, the SUMO conjugating enzyme [PDF]
Virus Research, 2011 The human papillomavirus oncogenic protein, E6, interacts with a number of cellular proteins, and for some targets, E6 directs their degradation through the ubiquitin-proteasome pathway. Post-translational modification with ubiquitin-like modifiers, such as SUMO, also influences protein activities, protein-protein interactions, and protein stability ...
Phillip R, Heaton +3 more
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A Method for SUMO Modification of Proteins in vitro
Bio-Protocol, 2018 The Small Ubiquitin-related Modifier (SUMO) is a protein that is post-translationally added to and reversibly removed from other proteins in eukaryotic cells.
Christine Lee +3 more
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The SUMO Ligase Protein Inhibitor of Activated STAT 1 (PIAS1) is a constituent PML-NB protein that contributes to the intrinsic antiviral immune response to herpes simplex virus 1 (HSV-1) [PDF]
, 2016 Aspects of intrinsic antiviral immunity are mediated by promyelocytic leukaemia (PML)-nuclear body (PML-NB) constituent proteins. During herpesvirus infection, these antiviral proteins are independently recruited to nuclear domains that contain infecting
Boutell, Chris +7 more
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Versatile recombinant SUMOylation system for the production of SUMO-modified protein. [PDF]
PLoS ONE, 2014 Posttranslational modification by small ubiquitin-like modifiers (SUMO) is being associated with a growing number of regulatory functions in diverse cellular processes.
Alain R Weber +2 more
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Regulation of SUMOylation by Reversible Oxidation of SUMO Conjugating Enzymes [PDF]
Molecular Cell, 2006 Posttranslational modification with small ubiquitin-related modifier (SUMO) has emerged as a central regulatory mechanism of protein function. However, little is known about the regulation of sumoylation itself. It has been reported that it is increased after exposure to various stresses including strong oxidative stress. Conversely, we report that ROS
Bossis, G., Melchior, Frauke
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The maize SUMO conjugating enzyme ZmSCE1b protects plants from paraquat toxicity
Ecotoxicology and Environmental Safety, 2021 Paraquat (PQ) herbicide causes damage to green plant tissues by inducing the production of toxic reactive oxygen species (ROS). SUMOylation is an important post-translational modification that enables plants to defend against multiple stresses. However, it is still unknown whether the SUMOylation is involved in PQ resistance response in crops.
Huanyan Wang +4 more
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