Results 291 to 300 of about 1,958,325 (325)

SUMO Conjugation and SUMO Chain Formation by Plant Enzymes

2022
SUMO conjugation is a conserved process of eukaryotes, and essential in metazoa. Similar to ubiquitylation, a SUMO-activating enzyme links to the SUMO carboxyl-terminal Gly in a thioester bond, and a SUMO-conjugating enzyme accepts activated SUMO and can transfer it to substrates.
Tomanov, Konstantin, Julian, Jose, Ziba, Ionida, Bachmair, Andreas   +3 more
openaire   +3 more sources

A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly [PDF]

Nature Structural & Molecular Biology, 2015
SUMO chains act as stress-induced degradation tags or repair factor-recruiting signals at DNA lesions. Although E1 activating, E2 conjugating and E3 ligating enzymes efficiently assemble SUMO chains, specific chain-elongation mechanisms are unknown.
Andrea Pichler, Jan Rettich, Päivi Sutinen, Susumu Y. Imanishi, Susumu Y. Imanishi, Nathalie Eisenhardt, Esen Dogan, Esen Dogan, Jorma J. Palvimo, Stefanie Koidl, Kay Hofmann, Viduth K. Chaugule, Viduth K. Chaugule, Mathias Droescher   +13 more
openaire   +2 more sources

Arabidopsis SUMO E3 ligase SIZ1 enhances cadmium tolerance via the glutathione-dependent phytochelatin synthesis pathway.

Plant Science, 2022
Sumoylation is a posttranslational modification (PTM) in which SUMO (small ubiquitin-like modifier) is covalently conjugated to protein substrates via a range of enzymes.
Ting Zheng, Guo-De Wu, Xiang Tao, Bing He   +3 more
semanticscholar   +1 more source

SUMO Ubc9 enzyme as a viral target

IUBMB Life, 2014
Viruses alter specific host cell targets to counteract possible defense mechanisms aimed at eliminating infectivity and viral propagation. The SUMO conjugating enzyme Ubc9 functions as a hub for protein sumoylation, whilst also providing an interactive surface for sumoylated proteins through noncovalent interactions.
Varadaraj A., Mattoscio D., Chiocca S.
openaire   +4 more sources

Expression and regulation of the mammalian SUMO‐1 E1 enzyme

The FASEB Journal, 2001
SPECIFIC AIMSSUMO-1 E1 enzyme subunits associate as a simple heterodimeric complex, but purified E1 heterodimer plus the E2 enzyme is significantly less efficient than cellular extracts in catalyzing SUMO-1 conjugation, suggesting the existence of previously uncharacterized positive regulators of this reaction.
Yoshiaki Azuma, Alexandra M. Ainsztein, Margaret M. Cavenagh, Mary Dasso, Hisato Saitoh, Shyh-Han Tan   +5 more
openaire   +3 more sources

Molecular mechanisms in SUMO conjugation.

Biochemical Society Transactions, 2019
The small ubiquitin-like modifier (SUMO) is a post-translational modifier that can regulate the function of hundreds of proteins inside the cell. SUMO belongs to the ubiquitin-like family of proteins that can be attached to target proteins by a dedicated
N. Varejão, Jara Lascorz, Ying Li, D. Reverter   +3 more
semanticscholar   +1 more source

Signalling mechanisms and cellular functions of SUMO

Nature reviews. Molecular cell biology, 2022
A. Vertegaal
semanticscholar   +1 more source

Structure of ubiquitin-conjugating enzyme 9 displays significant differences with other ubiquitin-conjugating enzymes which may reflect its specificity for sumo rather than ubiquitin.

Acta Crystallographica Section D: Biological Crystallography, 1998
The three-dimensional structure of ubiquitin-conjugating enzyme 9 (Ubc9) has been obtained to a resolution of 2.8 A by molecular replacement followed by a combination of automated refinement and graphical intervention. Diffraction data were recorded on a
M. Giraud, J. Desterro, J. Naismith
semanticscholar   +1 more source

Sequence Search and Comparative Genomic Analysis of SUMO-Activating Enzymes Using CoGe

2016
The growing number of genome sequences completed during the last few years has made necessary the development of bioinformatics tools for the easy access and retrieval of sequence data, as well as for downstream comparative genomic analyses. Some of these are implemented as online platforms that integrate genomic data produced by different genome ...
Victor A. Albert, Lorenzo Carretero-Paulet   +1 more
openaire   +3 more sources

The rice SUMO conjugating enzymes OsSCE1 and OsSCE3 have opposing effects on drought stress.

Journal of plant physiology, 2019
J. Joo, D. Choi, Youn Hab Lee, H. Seo, S. Song   +4 more
semanticscholar   +1 more source