Insights in Post-Translational Modifications: Ubiquitin and SUMO
International Journal of Molecular Sciences, 2022 Both ubiquitination and SUMOylation are dynamic post-translational modifications that regulate thousands of target proteins to control virtually every cellular process.
D. Salas-Lloret, R. González-Prieto
semanticscholar +1 more source
Dynamic SUMO remodeling drives a series of critical events during the meiotic divisions in Caenorhabditis elegans. [PDF]
PLoS Genetics, 2018 Chromosome congression and segregation in C. elegans oocytes depend on a complex of conserved proteins that forms a ring around the center of each bivalent during prometaphase; these complexes are then removed from chromosomes at anaphase onset and ...
Amanda C Davis-Roca +3 more
doaj +1 more source
Sumo E2 Enzyme UBC9 Is Required for Efficient Protein Quality Control in Cardiomyocytes [PDF]
Circulation Research, 2014 Rationale: Impairment of proteasomal function is pathogenic in several cardiac proteinopathies and can eventually lead to heart failure. Loss of proteasomal activity often results in the accumulation of large protein aggregates.
Manish Gupta +5 more
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PLOS ONE, 2016 In previous work, small ubiquitin-like modifier (SUMO) in hemocytes of Chinese shrimp Fenneropenaeus chinensis was found to be up-regulated post-white spot syndrome virus (WSSV) infection using proteomic approach. However, the role of SUMO in viral infection is still unclear.
Xiaoqian Tang +4 more
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Structural basis for the SUMO protease activity of the atypical ubiquitin-specific protease USPL1
Nature Communications, 2022 Post-translational protein modifications by ubiquitin and ubiquitin-like modifiers regulate many major pathways in the cell. These modifications can be reversed by de-ubiquitinating enzymes such as ubiquitin-specific proteases (USPs).
Ying Li, N. Varejão, D. Reverter
semanticscholar +1 more source
Functional reconstitution of a tunable E3-dependent sumoylation pathway in Escherichia coli. [PDF]
PLoS ONE, 2012 SUMO (small ubiquitin-related modifier) is a reversible post-translational protein modifier that alters the localization, activity, or stability of proteins to which it is attached.
Sean P O'Brien, Matthew P DeLisa
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Auto-sumoylation of the yeast Ubc9 E2 SUMO-conjugating enzyme extends cellular lifespan. [PDF]
Nat CommunJeong DW +10 more
europepmc +2 more sources
Cancer-Associated Dysregulation of Sumo Regulators: Proteases and Ligases
International Journal of Molecular Sciences, 2022 SUMOylation is a post-translational modification that has emerged in recent decades as a mechanism involved in controlling diverse physiological processes and that is essential in vertebrates.
Nieves Lara-Ureña +2 more
semanticscholar +1 more source
Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme [PDF]
Cell Chemical Biology, 2018 Ubiquitin-like (Ubl) post-translational modifications are potential targets for therapeutics. However, the only known mechanism for inhibiting a Ubl-activating enzyme is through targeting its ATP-binding site. Here we identify an allosteric inhibitory site in the small ubiquitin-like modifier (SUMO)-activating enzyme (E1).
Yijia Li +16 more
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bioRxiv, 2022 Ubiquitin and ubiquitin-like conjugation cascades consist of dedicated E1, E2 and E3 enzymes with E3s providing substrate specificity. Mass spectrometry-based approaches have enabled the identification of more than 60,000 acceptor sites for ubiquitin and
D. Salas-Lloret +11 more
semanticscholar +1 more source