Results 51 to 60 of about 28,838 (280)
Cell Reports, 2014 Chemotherapeutic drugs used in the treatment of acute myeloid leukemias (AMLs) are thought to induce cancer cell death through the generation of DNA double-strand breaks.
Guillaume Bossis +15 more
doaj +1 more source
A role for SUMO modification in transcriptional repression and activation [PDF]
, 2007 Since the discovery of the SUMO (small ubiquitin-like modifier) family of proteins just over a decade ago, a plethora of substrates have been uncovered including many regulators of transcription.
David +26 more
core +1 more source
The Role of the Small Ubiquitin-Related Modifier (SUMO) Pathway in Prostate Cancer
Biomolecules, 2012 SUMO (small ubiquitin-related modifier) conjugation is a reversible three-step process of protein post-translational modifications mediating protein-protein interactions, subcellular compartmentalization and regulation of transcriptional events.
Christos N. Papandreou +1 more
doaj +1 more source
Plant Direct, 2020 Small ubiquitin‐like modifier (SUMO) conjugation, or SUMOylation, is a reversible post‐translational modification that is important for regulation of many cellular processes including cell division cycle in the eukaryotic kingdom. However, only a portion
Yen‐Ling Lin +4 more
doaj +1 more source
The ubiquitin-proteasome pathway in Huntington's disease. [PDF]
, 2008 The accumulation of mutant protein is a common feature of neurodegenerative disease. In Huntington's disease, a polyglutamine expansion in the huntingtin protein triggers neuronal toxicity.
Finkbeiner, Steven, Mitra, Siddhartha
core +2 more sources
SUMO modification of the ubiquitin-conjugating enzyme E2-25K
Nature Structural & Molecular Biology, 2005 Post-translational modification with small ubiquitin-related modifier (SUMO) alters the function of many proteins, but the molecular mechanisms and consequences of this modification are still poorly defined. During a screen for novel SUMO1 targets, we identified the ubiquitin-conjugating enzyme E2-25K (Hip2).
Pichler, A. +8 more
openaire +5 more sources
Purification of SUMO Conjugating Enzymes and Kinetic Analysis of Substrate Conjugation [PDF]
, 2009 SUMO conjugation to protein substrates requires the concerted action of a dedicated E2 ubiquitin conjugation enzyme (Ubc9) and associated E3 ligases. Although Ubc9 can directly recognize and modify substrate lysine residues that occur within a consensus site for SUMO modification, E3 ligases can redirect specificity and enhance conjugation rates during
Ali A, Yunus, Christopher D, Lima
openaire +2 more sources
N-terminal α-amino SUMOylation of cofilin-1 is critical for its regulation of actin depolymerization
Nature Communications, 2023 Small ubiquitin-like modifier (SUMO) typically conjugates to target proteins through isopeptide linkage to the ε-amino group of lysine residues. This posttranslational modification (PTM) plays pivotal roles in modulating protein function.
Weiji Weng +10 more
doaj +1 more source
Ubiquitination accomplished: E1 and E2 enzymes were not necessary [PDF]
, 2016 Qiu et al. (2016) show that a mono-ADP-ribosyltransferase, SdeA, from Legionella pneumophila catalyzes ADP-ribosylation of ubiquitin, allowing SdeA to modify substrate with ubiquitin in the absence of E1 and E2 ...
Huang, Danny T., Nakasone, Mark
core +1 more source
Characterization of SUMO-conjugating enzyme mutants in Schizosaccharomyces pombe identifies a dominant-negative allele that severely reduces SUMO conjugation [PDF]
Biochemical Journal, 2003 The phenotypes of mutants defective in the Schizosaccharomyces pombe SUMO (small, ubiquitin-like modifier)-conjugating enzyme Hus5 (the homologue of Ubc9) show that it is required for recovery from S-phase arrest. Unlike the case with ubiquitination, where ligases are required, SUMO-conjugating enzymes are sufficient for substrate recognition and ...
Jenny C Y, Ho, Felicity Z, Watts
openaire +2 more sources